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Acquired hydrocephalus IV. Determination of the absorption rate of albumin from the cerebrospinal fluid

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Summary

By quantitative isotope ventriculography (QIV), the absorption rate (λ2) of albumin in the cerebrospinal fluid (CSF) was determined. Regard was paid to the rate constants for the exchange of the albumin molecule between the serum and extravascular phase.

The rate constant λ2 and mean biological transit time Tmb−2 were determined in 22 patients suspected of acquired hydrocephalus. QIV revealed that 8 patients were hydrocephalic, while 13 were non-hydrocephalic, and the findings were uncertain in one.

In the patients with acquired hydrocephalus, it was demonstrated that λ2 and Tmb−2 were significantly reduced as compared with the non-hydrocephalic patients. By means of QIV, a curve was calculated and plotted for the biological decay from the head—the retention curve. From the initial slope of this curve (0–24 hours), the rate constant λ4 was calculated. A comparison of λ4 and λ2 revealed a highly significant correlation, which means that the retention curve gives an acceptable measure of the absorption rate of CSF-albumin.

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References

  1. Abbott, M., Alksne, J. F., Transport of intrathecal I125 RISA to circulating plasma. Neurology18 (1968), 870–874.

    PubMed  Google Scholar 

  2. Atkinson, J. R., Foltz, E. L., Intraventricular “RISA” as a diagnostic aid in pre- and postoperative hydrocephalus. J. Neurosurg.19 (1961), 159–166.

    Google Scholar 

  3. Bannister, R., Gilford, E., Kocen, R., Isotope encephalography in the diagnosis of dementia due to communicating hydrocephalus. Lancetii (1967), 1014–1017.

    Google Scholar 

  4. Bannister, R., The place of isotope encephalography by lumbar route in neurological diagnosis. Proc. roy. soc. Med.63 (1970), 921–925.

    PubMed  Google Scholar 

  5. Barnes, B. D., Hoff, J. T., Radionuclide cisternography after head injury. Arch. Neurol.33 (1976), 21–25.

    PubMed  Google Scholar 

  6. Behrman, S., Cast, I., O'Gorman, P., Two types of curves for transfer of RHISA from cerebrospinal fluid to plasma in patients with normal pressure hydrocephalus. J. Neurosurg.35 (1971), 677–680.

    PubMed  Google Scholar 

  7. Belloni, G., DiRocco, C., Focacci, C., Galli, G., Maira, G., Rossi, G. F., Surgical indications in normotensive hydrocephalus. A retrospective analysis of the relations of some diagnostic findings to the results of surgical treatment. Acta Neurochir. (Wien)33 (1976), 1–21.

    Google Scholar 

  8. Bowsher, D., Pathways of absorption of protein from the cerebrospinal fluid. An autoradiographic study in the cat. Anat. Rec.128 (1957), 23–29.

    PubMed  Google Scholar 

  9. Brocklehurst, G., Further observations on the use of radio-iodinated serum albumin in the study of CSF flow. In: Cisternography and hydrocephalus, pp. 513–520. Springfield, Ill.: Ch. C Thomas. 1972.

    Google Scholar 

  10. Chou, S. N., French, L. A., Systemic absorption and urinary excretion of RISA from subarachnoid space. Neurology14 (1955), 555–557.

    Google Scholar 

  11. Cold, G., Jensen, F., Malmros, R., Intraventricular isotope encephalography, continuous intraventricular pressure recording and biochemical changes in the cerebrospinal fluid in low-pressure hydrocephalus. Dan. med. Bull.24 (1977), 14–20.

    PubMed  Google Scholar 

  12. Courtice, F. C., Simmonds, W. J., The removal of protein from the subarachnoid space. Aust. J. exp. biol. Med. Sci.29 (1951), 255–263.

    PubMed  Google Scholar 

  13. Cutler, R. W. P., Deuel, R. K., Barlow, C. F., Albumin exchange between plasma and cerebrospinal fluid. Arch. Neurol.17 (1967), 261–270.

    PubMed  Google Scholar 

  14. Cutler, R. W. P., Page, L., Galicich, J., Watters, G. V., Formation and absorption of cerebrospinal fluid in man. Brain91 (1968), 707–720.

    PubMed  Google Scholar 

  15. Cutler, R. W. P., Watters, G. V., Hammerstad, J. P., The origin and turnover rates of cerebrospinal fluid albumin and gammaglobulin in man. J. neurol. Sci.10 (1970), 259–268.

    PubMed  Google Scholar 

  16. Davson, H., Hollingworth, G., Segal, M. B., The mechanism of drainage of the cerebrospinal fluid. Brain93 (1970), 665–678.

    PubMed  Google Scholar 

  17. Di Chiro, G., Radiographic and isotopic procedures in neurological diagnosis. J. amer. med. Ass.188 (1964), 524–529.

    Google Scholar 

  18. Di Chiro, G., Cisternography: from early tribulations to a useful diagnostic procedure. J. H. med. J.133 (1973), 1–15.

    Google Scholar 

  19. Di Chiro, G., Hammock, M. K., Bleyer, A., Spinal descent of cerebrospinal fluid in man. Neurology26 (1976), 1–8.

    PubMed  Google Scholar 

  20. Ekstedt, J., Friden, H., CSF hydrodynamics especially in the adult hydrocephalus syndrome. In: Intracranial pressure III, pp. 177–185. Berlin-Heidelberg-New York: Springer. 1976.

    Google Scholar 

  21. Ekstedt, J., CSF hydrodynamic studies in man. Method of constant pressure CSF infusion. J. Neurol. Neurosurg. Psychiat.40 (1977), 105–119.

    PubMed  Google Scholar 

  22. Fishman, R. A., Exchange of albumin between plasma and cerebrospinal fluid. Amer. J. Physiol.96 (1953), 175–177.

    Google Scholar 

  23. Galli, G., Troncone, L., Rossi, G.,131I-HSA cisternography and131I-HSA transfer from CSF to blood in normal pressure hydrocephalus. J. nucl. biol. Med.17 (1973), 64–70.

    PubMed  Google Scholar 

  24. Glasauer, F. E., Alker, G. J., Leslie, E. V., Isotope cisternography and ventriculography. Amer. J. dis. Child.120 (1970), 109–114.

    PubMed  Google Scholar 

  25. Glasauer, F. E., Isotope cisternography and ventriculography in congenital CNS anomalies. Child's Brain1 (1975), 116–120.

    PubMed  Google Scholar 

  26. Heinz, E., Davis, D. O., Karp, H. R., Abnormal isotope cisternography in symptomatic occult hydrocephalus. Radiology95 (1970), 109–120.

    PubMed  Google Scholar 

  27. Heisey, S. R., Held, D., Pappenheimer, R., Bulk flow and diffusion in the cerebrospinal fluid system of the goat. Amer. J. Physiol.203 (1962), 775–781.

    PubMed  Google Scholar 

  28. Hussey, F., Schanzer, B., Katzman, R., A simple constant-infusion manometric test for measurement of CSF absorption. II. Clinical studies. Neurology20 (1970), 665–680.

    PubMed  Google Scholar 

  29. Jensen, F., Malmros, R., Hvid Hansen, H., Cold, G., Intraventricular isotope encephalography. A methodological study. Dan. med. Bull.24 (1977), 7–14.

    PubMed  Google Scholar 

  30. Jensen, F., Jensen, F. T., Acquired hydrocephalus. I. A clinical analysis of 160 patients studied for hydrocephalus. Acta Neurochir. (Wien)46 (1979), 119–133.

    Google Scholar 

  31. Jensen, F., Jensen, F. T., Acquired hydrocephalus. II. Diagnostic and prognostic value of quantitative isotope ventriculography, lumbar isotope cisternography, pneumoencephalography and continuous intraventricular pressure recording. Acta Neurochir. (Wien)46 (1979), 243–257.

    Google Scholar 

  32. Jensen, F., Acquired hydrocephalus. III. A neuropathological study correlated with patophysiology and clinical manifestations. Acta Neurochir. (Wien)47 (1979), 91–104.

    Google Scholar 

  33. Jensen, F., Jensen, F. T., Acquired hydrocephalus V. Determination of the formation rate of albumin in the ventricular system. Acta Neurochir. (Wien)48 (1979), in press.

  34. Katzman, R., Hussey, F., A simple constant-infusion manometric test for measurement of CSF absorption. Neurology20 (1970), 534–544.

    PubMed  Google Scholar 

  35. Katzman, R., Coblentz, J., Studies of CSF dynamics in histologically verified presenile dementias. Trans. Amer. neurol. Ass.97 (1972), 160–164.

    Google Scholar 

  36. Lorenzo, A. V., Page, L. K., Watters, G. V., Relationship between cerebrospinal fluid formation, absorption and pressure in human hydrocephalus. Brain93 (1970), 679–692.

    PubMed  Google Scholar 

  37. Lorenzo, A. V., Bresman, M. J., Deficit in cerebrospinal fluid absorption in patients with symptoms of normal pressure hydrocephalus. Dev. med. Child. Neurol.29 (1973), 35–41.

    Google Scholar 

  38. Marmarou, A., Shulman, K., LaMorgese, J., Compartmental analysis of compliance and outflow resistance of the cerebrospinal fluid system. J. Neurosurg.43 (1975), 523–534.

    PubMed  Google Scholar 

  39. Page, L. K., Bresman, M. J., Lorenzo, A. V., Cerebrospinal fluid perfusion studies in childhood hydrocephalus. Surg. Neurol.1 (1973), 317–320.

    PubMed  Google Scholar 

  40. Pappenheimer, J. R., Heisey, S. R., Jordan, E. F., Active transport of diodrast and phenolsulfonphthalein from cerebrospinal fluid to blood. Amer. J. Physiol.200 (1961), 1–10.

    PubMed  Google Scholar 

  41. Pappenheimer, J. R., Heisey, S. R., Jordan, E. F., Downer, J. de C., Perfusion of the cerebral ventricular system in unanesthetized goats. Amer. J. Physiol.203 (1962), 763–774.

    Google Scholar 

  42. Philipson, J., George, B., Levante, A., Thurel, C., Visot, A., Cophignon, J., Subarachnoid infusion test. Its value in the prognosis of shunted normal pressure hydrocephalus. In: Intracranial Pressure III, pp. 193–198. Berlin-Heidelberg-New York: Springer. 1976.

    Google Scholar 

  43. Portnoy, H. D., Croissant, P. D., A practical method for measuring hydrodynamics of cerebrospinal fluid. Surg. Neurol.5 (1976), 273–277.

    PubMed  Google Scholar 

  44. Rubin, R. C., Henderson, E. S., Ommaya, A. K., Walker, M. D., Rall, D. P., The production of cerebrospinal fluid in man and its modification by acetazolamide. J. Neurosurg.25 (1966), 430–436.

    PubMed  Google Scholar 

  45. Sweet, W. H., Selverstone, B., Soloway, S., Stetten, D., Studies of formation, flow and absorption of cerebrospinal fluid. Surg. Forum1 (1950), 376–381.

    Google Scholar 

  46. Sweet, W. H., Locksley, H. B., Formation, flow and reabsorption of cerebrospinal fluid in man. Proc. soc. exp. Biol. Med.84 (1953), 397–402.

    PubMed  Google Scholar 

  47. Sweet, W. H., Historical development of tracer uses in CSF dynamics. In: Central nervous system investigation with radionuclides, pp. 39–51. Springfield, Ill.: Ch. C Thomas. 1971.

    Google Scholar 

  48. Sweet, W. H., Brownell, G. L., Scholl, J. A., Bowsher, D. R., Benda, P., Stickley, E. E., The formation, flow and absorption of cerebrospinal fluid; newer concepts based on studies with isotopes. In: Neurology and psychiatry in childhood, pp. 101–159. Baltimore: The Williams and Wilkins company. 1974.

    Google Scholar 

  49. Stevenaert, A., Godin, D., Depresseux, J. C., Ventriculolumbar perfusion in adult communicating hydrocephalus. In: Intracranial pressure III, pp. 186–192. Berlin-Heidelberg-New York: Springer. 1976.

    Google Scholar 

  50. Tator, C. H., Fleming, J. F. R., Sheppard, R. H., Turner, V. M., Studies of cerebrospinal fluid dynamics with intrathecally administered radioiodinated human serum albumin (131 IHSA). Canad. med. Ass. J.97 (1967), 493–503.

    PubMed  Google Scholar 

  51. Welch, K., Friedman, V., The cerebrospinal fluid valves. Brain83 (1960), 454–469.

    PubMed  Google Scholar 

  52. Wolpert, S. M., Carney, P. M., Rabe, E. F., Studies on the fate of intraventricular131I-HSA in infants and children with progressive macrocephaly. Comparative study of computer-analyzed gamma camera data with quantitative ventriculoplasma transport. In: Cisternography and hydrocephalus, pp. 453–463. Springfield, Ill.: Ch. C Thomas. 1972.

    Google Scholar 

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  1. F. Jensen

    Present address: Department of Neurosurgery, Aarhus Kommunehospital, Aarhus C, Denmark

Authors and Affiliations

  1. Department of Neurosurgery, Aarhus Kommunehospital, Aarhus C, Denmark

    K. J. Olsen

  2. Department of Nuclear Medicine, Aarhus Kommunehospital, Aarhus C, Denmark

    F. Jensen & K. J. Olsen

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Jensen, F., Olsen, K.J. Acquired hydrocephalus IV. Determination of the absorption rate of albumin from the cerebrospinal fluid. Acta neurochir 48, 17–33 (1979). https://doi.org/10.1007/BF01406017

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