Summary
In tranquilised spontaneously breathing rhesus monkeys we have found that trimethaphan can reduce systemic blood pressure by 20% with little or no change in CBF. This was in marked contrast to those given nitroprusside which showed signs of loss of autoregulation at a 5% MBP reduction. It is our opinion that the divergence of these results from other work might be explained in part by differing anaesthetic techniques and species variations. On this experience we would be hesitant to use sodium nitroprusside or a hypotensive agent in any patient where cerebral blood flow might be already compromised.
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References
Boysen, G., Collateral circulation during carotid clamping: The interrelationship between CBF, stump pressure and E.E.G. Acta Neurol. Scand. (Suppl.)51 (1972), 421–422.
Branston, N. M., Symon, L., Crockard, H. A., Pasztor, E., Relationship between the cortical evoked potential and local cortical blood flow following acute middle cerebral artery occlusion in the baboon. Exp.Neurol.45 (1974), 195–208.
Carter, L. P., Atkinson, J. R., Cortical blood flow in controlled hypotension as measured by thermal diffusion. J. Neurol. Neurosurg. Psychiat.36 (1973), 906–913.
Franciosa, J. A., Guiha, N. H., Limas, C.J.et al., Improved left ventricular function during Nitroprusside infusion in acute myocardial infarction. Lancet1 (1972), 650–654.
Koch-Weser, J., Hypertensive Emergencies. N. Eng. J. Med.290 (1974), 211–214.
Olesen, J., Paulson, O. B., Lassen, N. A., Regional cerebral blood flow in man determined by the initial slope of the clearance of intraarterially injected133Xe. Stroke2 (1971), 519–540.
Olesen, J., Quantitative evaluation at normal and pathologic cerebral blood flow regulation to perfusion pressure. Arch. Neurol.28 (1973), 143–149.
Rapela, C. B., Green, H. D., Auto-regulation of canine cerebral blood flow. Circ. Res.15 (1964), 205–211.
Rowe, G. G., Henderson, R. H., Systemic and coronary hemodynamic effects at sodium nitroprusside. Am. Heart J.87 (1974), 83–87.
Stoyka, W. W., Schutz, H., Effects of trimethaphan and sodium nitroprusside on canine cerebral blood flow and metabolism. Canad. Anaesth. Soc. J.22 (1975), 275–283.
Sundt, T. M., Sharbrough, R. W., Anderson, R. E.et al., Cerebral blood flow measurements and electroencephalograms during carotid endarterrectomy. J. Neurosurg.41 (1974), 310–319.
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Crockard, H.A., Brown, F.D. & Mullan, J.F. Effects of trimethaphan and sodium nitroprusside on cerebral blood flow in rhesus monkeys. Acta neurochir 35, 85–89 (1976). https://doi.org/10.1007/BF01405936
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DOI: https://doi.org/10.1007/BF01405936