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Changes in serum and cerebrospinal fluid enzyme activity after head injury

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Summary

We studied simultaneously in serum (S) and CSF (L) the enzyme activities of GOT, GPT, LDH, ICDH, MDH, ALD, and CPK in 28 patients with head injuries divided into three groups according to the severity of the trauma. We found a correlation between severity of brain lesion and enzyme activity. The best correlation was found for SGOT, SCPK, LGOT, LLDH, LMDH and LCPK. We do not believe that enzyme activity is of prognostic value. We think that further studies should be made of the specific isoenzymes of the Central Nervous System.

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Author notes

  1. G. Flórez, A. Cabeza, J. M. Gonzalez, J. Garcia & S. Ucar

    Present address: Department of Neurosurgery and Clinical Laboratory, Centro de Rehabilitación y Traumatologia de la S. S., Zaragoza, Spain

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    1. G. Flórez
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    2. A. Cabeza
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    3. J. M. Gonzalez
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    4. J. Garcia
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    5. S. Ucar
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    Flórez, G., Cabeza, A., Gonzalez, J.M. et al. Changes in serum and cerebrospinal fluid enzyme activity after head injury. Acta neurochir 35, 3–13 (1976). https://doi.org/10.1007/BF01405928

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