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Intrathecal pharmaeotherapy in coma

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Summary

A study was made of intrathecal infusion as a route for administration of drugs for the CNS. We recognize the presence of blood brain and CSF brain barriers. CDP-choline was used as the brain activator, and the effect of the intrathecally infused drug was investigated clinically. Fifteen patients with disturbances of consciousness due to primary cerebral lesions received a total of 39 intrathecal infusions of CDP-choline, and were examined neurologically and electroencephalographically before and after treatment.

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Author notes

  1. M. Ogashiwa

    Present address: Department of Neurosurgery, Kyorin University, Japan

Authors and Affiliations

  1. Department of Neurosurgery, Kyorin University, Japan

    K. Takeuchi

Authors
  1. M. Ogashiwa
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  2. K. Takeuchi
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Ogashiwa, M., Takeuchi, K. Intrathecal pharmaeotherapy in coma. Acta neurochir 34, 37–44 (1976). https://doi.org/10.1007/BF01405861

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  • DOI: https://doi.org/10.1007/BF01405861

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