Summary
The concentration of CK and LDH in the cerebrospinal fluid was determined in 290 patients with head injuries. The highest concentration of these enzymes appeared in patients with the most severe brain injury. CK correlated somewhat better than LDH with the severity of the head injury. In the group with moderate head injuries there was no significant difference statistically between patients with increased CK level and patients with normal CK level in the cerebrospinal fluid with regard to the duration of posttraumatic headache, dizziness or working disability.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Culebras-Fernández, A., and N. G. Richards, Glutamic oxalacetic transaminase, lactic dehydrogenase, and creatine phosphokinase content in cerebrospinal fluid. Cleveland Clinic Quarterly.38 (1971), 113–118.
Heller, W., und P. Oldenkott, Klinisch-chemische Diagnostik bei Hirntumoren und Hirnverletzungen. Dtsch. med. Wschr.96 (1971), 1222–1224.
— —, W. Driesen, W. Elies, und H. Blankenhorn, Klinisch-chemische Untersuchungen zur Früherfassung von bösartigen Hirn-Tumoren. ärztliche Forschung25 (1971), 44–47.
Kaltiala, E. H., E. S. Heikkinen, N. T. Kärki, and T. K. I. Larmi, Cerebrospinal fluid and serum transaminases and lactic dehydrogenase after head injury. Acta Neurol. Scandinav.44 (1968), 124–129.
Katz, R. M., and W. Liebmann, Creatine phosphokinase activity in central nervous system disorders and infections. Amer. J. Dis. Child.120 (1970), 543–546.
Kay, D. W. K., T. A. Kerr, and L. P. Lassman, Brain trauma and the postconcussional syndrome. Lancet II (1971), 1052–1055.
Kleine, T. O., Zur Lokalisation der Creatinkinase (CK) in Mitochondrien und Mikrosomen von Skelettmuskel, Herz und Hirnrinde des Menschen. Klin. Wschr.43 (1965), 504–510.
KlØve, H., and C. S. Cleeland, The relationship of neuropsychological impairment to other indices of severity of head injury. Scand. J. Rehab. Med.4 (1972), 55–60.
Lindblom, U., and B. åberg, The pattern of S-LDH isoenzymes and S-GOT after traumatic brain injury. Scand. J. Rehab. Med.4 (1972), 61–72.
Rabow, L., B. Hebbe, and G. Lieden, Enzyme analysis for evaluating acute head injury. Acta Chir. Scand.137 (1971), 305–309.
Rosalki, S. B., An improved procedure for serum creatine phosphokinase determination. J. Lab. Clin. Med.69 (1967), 696–705.
Schuller, E., Phospho-creatine-kinase plasmatique et maladies du systeme nerveux. Presse Medical76 (1968), 2273–2274.
Tveit, B., and I. Runde, The effect of enzyme concentration and serum concentration on initial rate measurements of serum enzymes. Scand. J. Clin. Lab. Invest.27 (1971), 161–167.
Van der Veen, K. J., and A. F. Willebrands, Isoenzymes of creatine phosphokinase in tissue extracts and in normal and pathological sera. Clin. Chim. Acta13 (1966), 312–316.
Wolintz, A. H., L. D. Jacobs, N. Christoff, M. Solomon, and N. Chernik, Serum and cerebrospinal fluid enzymes in cerebrovascular disease. Arch. Neurol.20 (1969), 54–61.
Wroblewski, F., and J. S. La Due, Lactic dehydrogenase in blood. Proc. Soc. Exper. Biol. Med.90 (1955), 210–213.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nordby, H.K., Tveit, B. & Ruud, I. Creatine kinase and lactate dehydrogenase in the cerebrospinal fluid in patients with head injuries. Acta neurochir 32, 209–217 (1975). https://doi.org/10.1007/BF01405454
Issue Date:
DOI: https://doi.org/10.1007/BF01405454