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Mammalian cell transformation assays: What role can they play in the identification of carcinogens?

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Journal of tissue culture methods

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References

  1. Balmain, A.; Pragnell, I. B. Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvy-ras oncogene. Nature 303:72–74; 1983.

    PubMed  Google Scholar 

  2. Barrett, J. C.; Oshimura, M. Oncogenes and tumor suppressor genes in multistep carcinogenesis: Relevance to toxicological studies of carcinogens.

  3. Bishop, M. J. Cellular oncogenes and retroviruses. Ann. Rev. Biochem. 52:301–354; 1983.

    PubMed  Google Scholar 

  4. Bradshaw, T. K. Cell transformation: The role of oncogenes and growth factors. Mutagenesis 1:91–97; 1986.

    PubMed  Google Scholar 

  5. DiPaolo, J. A. Relative difficulties in transforming human and animal cells in vitro. JNCI 70:3–8; 1983.

    PubMed  Google Scholar 

  6. Dunkel, V. C.; Pienta, R. J.; Sivak, A., et al. Comparative neoplastic transformation reponses of Balb/3T3 cells, Syrian hamster embryo cells, and Rauscher Murine leukemia virus-infected Fischer 344 rat embryo cells to chemical carcinogens. JNCI 6:1303–1312; 1981.

    Google Scholar 

  7. Farber, E.; Cameron, R. The sequential analysis of cancer development. Adv. Cancer Res. 35:125–226; 1980.

    Google Scholar 

  8. Hatch, G. G.; Anderson, T. M., Lubet, R. A., et al. Evaluation of chemical enhancement of SA7 virus transformation of hamster embryo cells in the interlaboratory testing of diverse chemicals. Environ. Mutagen. 8(4):515–532; 1986.

    PubMed  Google Scholar 

  9. Hayward, W. S.; Neel, B. G.; Astrin, S. M. Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis. Nature 290:475–480; 1981.

    PubMed  Google Scholar 

  10. Heidelberger, C.; Freeman, A. E.; Pienta, R. J., et al. Cell transformation by chemical agents—A review and analysis of the literature. Mutat. Res. 114(3):283–385; 1983.

    PubMed  Google Scholar 

  11. Heldin, C. H.; Westermark, B. Growth factors: Mechanism of action and relation to oncogenes. Cell 37:9–20; 1984.

    PubMed  Google Scholar 

  12. Huff, J. E.; Hasman, J. K.; McConnell, E. E., et al. The National Toxicology Program, toxicology data evaluation techniques and long-term carcinogenesis studies. In: Lloyd, W.E., ed. Safety evaluation of drugs and chemicals. Washington, DC: Hemisphere Press; 1985:411–447.

    Google Scholar 

  13. Nettesheim, P.; Barrett, J. C. In vitro transformation of rat trachael epithelial cells: A model for the study of multistage carcinogenesis. In: Barrett, J. C.; Tennant, R. W., eds. Carcinogenesis, vol. 9. New York: Haven Press; 1985:283–292.

    Google Scholar 

  14. Newbold, R. F. Multistep malignant transformation of mammalian cells by carcinogens. Induction of immortality as a key event in carcinogenesis. In: Barrett, J. C.; Tennant, R. W., eds. Carcinogenesis, vol. 9. New York: Raven Press; 1985:17–28.

    Google Scholar 

  15. Pitot, H. C.; Goldsworthy, T.; Moran, S. The natural history of carcinogenesis: Implications of experimental carcinogenesis in the genesis of cancer. J. Supramolec. Struct. Cell. Biochem. 17:133–146; 1981.

    Google Scholar 

  16. Rubin, H.; Chu, B. M.; Arnstein, P. Heritable variations in growth potential and morphology within a clone of Balb/3T3 cells and their relation to tumor formation. JNCI 71:365–373; 1983.

    PubMed  Google Scholar 

  17. Schwab, M.; Alitalo, K., Varmus, H. E., et al. A cellular oncogene (c-Kisras) is amplified, overexpressed, and localized within karyotypic abnormalities in mouse adrenocortical tumor cells. Nature 303:497–501; 1983.

    PubMed  Google Scholar 

  18. Schechtman, L. M.; Hatch, G. G.; Anderson, T. M., et al. Analysis of the interlaboratory and intralaboratory reproducibility of the enhancement of Simian adenovirus SA7 transformation of Syrian hamster embryo cells by model carcinogenic and noncarcinogneic compounds. Environ. Mutagen. 8(4):495–514; 1986.

    PubMed  Google Scholar 

  19. Suk, W. A.; Poiley, J. A.; Raineri, R., et al. Chemical enhancement of survival in aggregation of retrovirus-infected rat cells: An interlaboratory comparison. Environ. Mutagen. 7(5):727–746; 1985.

    PubMed  Google Scholar 

  20. Tennant, R. W.; Margolin, B. H.; Shelby, M. D., et al. Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays. Science 236:933–941; 1987.

    PubMed  Google Scholar 

  21. Tennant, R. W.; Stasiewicz, S.; Spalding, J. W. Comparative evaluation of three mammalian cell transformation assay systems. In: Barrett, J. C.; Tennant, R. W., eds. Carcinogenesis, vol. 9. New York: Raven Press; 1985:399–410.

    Google Scholar 

  22. Tu, A.; Hallowell, W.; Pallotta, S., et al. An interlaboratory comparison of transformation in Syrian hamster embryo cells using model and coded chemicals. Environ. Mutagen. 8(1):77–98; 1986.

    PubMed  Google Scholar 

  23. Wiseman, R. W.; Stowers, S. J.; Miller, E. C., et al. Activating mutations of the c-Ha-ras protooncogenes in chemically induced hepatomas of the male B6C3F1 mouse. Proc. Natl. Acad. Sci. USA 83:5825–5829; 1986.

    PubMed  Google Scholar 

  24. Yunis, J. J. The chromosomal basis of human neoplasia. Science 221:227–236; 1983.

    PubMed  Google Scholar 

  25. Zarbl, H.; Suburar, S.; Arthur, A. V., et al. Direct mutagenesis of Ha-ras-1 oncogenes byN-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats. Nature 315:382–385; 1985.

    PubMed  Google Scholar 

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  1. Cellular and Genetic Toxicology Branch, National Institute of Environmental Health Sciences, 27709, Research Triangle Park, North Carolina

    Raymond W. Tennant

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  1. Raymond W. Tennant
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Tennant, R.W. Mammalian cell transformation assays: What role can they play in the identification of carcinogens?. Journal of Tissue Culture Methods 10, 205–207 (1986). https://doi.org/10.1007/BF01405085

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  • DOI: https://doi.org/10.1007/BF01405085

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