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Experimental cerebral concussion

A histochemical study

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Summary

The activity of mitochondrial enzymes (succinic dehydrogenase and cytochrome oxidase) and enzymes associated with blood-brain barrier function (butyrylcholinesterase and alkaline phosphatase) in the CNS of rats was studied from 5 minutes to 62 hours after cerebral concussion. There was a transient increase in succinic dehydrogenase activity during the first hour after concussion in the neurons of the structures close to the impact. The alkaline phosphatase activity, strongly positive in the walls of normal blood vessels, decreased within five minutes after concussion; it virtually disappeared in 15 minutes but returned to normal level after 62 hours. These findings are in good correlation with previous electron microscopic observations. Their significance is discussed.

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Author notes

  1. L. Bakay

    Present address: Department of Neurosurgery, State University of New York at Buffalo, Buffalo, New York

Authors and Affiliations

  1. Department of Neurosurgery, State University of New York at Buffalo, Buffalo, New York

    H. Ch. Liu & J. C. Lee

Authors
  1. H. Ch. Liu
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  2. J. C. Lee
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  3. L. Bakay
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Additional information

This work was supported by the Buswell Foundation and, in part, by the Research Institute of Alcoholism, Buffalo, New York.

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Liu, H.C., Lee, J.C. & Bakay, L. Experimental cerebral concussion. Acta neurochir 47, 105–122 (1979). https://doi.org/10.1007/BF01404667

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