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Modulation by interferon alpha of the decreased natural killer activity in patients with glioblastoma

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Summary

It is known that natural killer (NK) cells are involved in immunosurveillance against tumours. This study examines the NK activity of mononuclear cells (MNC) from the peripheral blood of patients with gliobalstoma. The cytotoxic inducer effect of interferonalpha (IFN-α) upon these MNC has also been studied. A marked decrease in NK activity mediated by MNC from these patients was found. This functional defected in MNC is not due to a decrease in phenotypically defined NK cells. After long-term (5-day) incubation with IFN-α, MNC from 5 out of 14 patients showed strong lytic activity against NK-sensitive target cells. In this system, IFN-α failed to induce cytotoxic activity against NK-resistant target cells in MNC from all the patients studied. Thisin vitro induction of cytotoxic activity in MNC from some patients with glioblastoma by IFN-α suggests a potential immunotherapeutic use of the lymphokine in these subjects.

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Author notes

  1. M. Alvarez-Mon

    Present address: Sevice of Internal Medicine, Department of Medicine, Hospital Universitario “Principe de Asturias”, Universidad de Alcalá de Henares, Spain

Authors and Affiliations

  1. Sevice of Internal Medicine, Department of Medicine, Hospital Universitario “Principe de Asturias”, Universidad de Alcalá de Henares, Spain

    P. Lapeña, C. Isasi, J. Vaquero & R. Martinez

  2. Division of Internal Medicine, Universidad Autónoma de Madrid, Madrid, Spain

    C. Isasi

  3. Division of Neurosurgery, Clinica Puerta de Hierro, Universidad Autónoma de Madrid, Madrid, Spain

    J. Vaquero & R. Martinez

Authors
  1. P. Lapeña
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  2. C. Isasi
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  3. J. Vaquero
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  4. R. Martinez
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  5. M. Alvarez-Mon
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Lapeña, P., Isasi, C., Vaquero, J. et al. Modulation by interferon alpha of the decreased natural killer activity in patients with glioblastoma. Acta neurochir 109, 109–113 (1991). https://doi.org/10.1007/BF01403004

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  • DOI: https://doi.org/10.1007/BF01403004

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