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Highly sensitive detection of beta-2 transferrin in rhinorrhea and otorrhea as a marker for cerebrospinal fluid (C.S.F.) leakage

Acta Neurochirurgica volume 109, pages 98–101 (1991)Cite this article

Summary

As beta-2 transferrin is almost specific to the cerebrospinal fluid, its detection in rhinorrhea or otorrhea fluids demonstrates the occurrence of CSF fistula. We describe a highly sensitive method based on immunoaffinity-mediated capillary blotting for the detection of this cathodic isoform of transferrin in minute amounts (3 μl) of rhinorrhea or otorrhea fluids. Application of this method in a series of 10 patients with CSF fistula is reported.

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Affiliations

  1. Unité de Neurochirurgie, Cliniques Universitaires Saint-Luc, Bruxelles, Belgium

    P. Fransen, C. Thauvoy & G. Stroobandt

  2. Laboratoire de Neurochimie, Université Catholique de Louvain, Bruxelles, Belgium

    C. J. M. Sindic & C. Laterre

Authors
  1. P. Fransen
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  2. C. J. M. Sindic
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  3. C. Thauvoy
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  4. C. Laterre
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  5. G. Stroobandt
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Fransen, P., Sindic, C.J.M., Thauvoy, C. et al. Highly sensitive detection of beta-2 transferrin in rhinorrhea and otorrhea as a marker for cerebrospinal fluid (C.S.F.) leakage. Acta neurochir 109, 98–101 (1991). https://doi.org/10.1007/BF01403002

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  • DOI: https://doi.org/10.1007/BF01403002

Keywords

  • Beta-2 transferrin
  • cerebrospinal fluid
  • CSF rhinorrhea
  • otorrhea