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Embolus radiolabelling in a new canine model

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Acta Neurochirurgica Aims and scope

Summary

Embolus radiolabelling with131I fibrinogen was studied in a canine model of internal carotid artery embolization. The dog was chosen as the experimental animal because of its maxillocarotid artery which permits collateral flow round the occlusion and helps to prevent strokes. Clot was prepared by incubating blood at room temperature to inactivate plasminogen activators and then refrigerating it to promote clot retraction. Emboli persisting 48 hours were seen in 80% of animals. Major strokes were not seen when 0.25 to 0.30 cm3 were used. Autoradiography and well counting revealed uptake of isotope. The test, when refined, should provide a tool for the investigation of thromboemboli.

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Author notes

  1. H. H. Kaufman

    Present address: Division of Neurosurgery, The University of Texas Medical School at Houston, USA

Authors and Affiliations

  1. Division of Neurosurgery, The University of Texas Medical School at Houston, USA

    J. D. Huchton

  2. Department of Pathology and Laboratory Medicine, The University of Texas Medical School at Houston, USA

    J. Woo & D. C. Cannon

  3. Department of Diagnostic Radiology, M. D. Anderson Hospital and Tumor Institute, Houston, Texas

    J. H. Anderson

Authors
  1. H. H. Kaufman
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  2. J. H. Anderson
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  3. J. Woo
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  4. J. D. Huchton
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  5. D. C. Cannon
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Kaufman, H.H., Anderson, J.H., Woo, J. et al. Embolus radiolabelling in a new canine model. Acta neurochir 52, 185–194 (1980). https://doi.org/10.1007/BF01402073

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  • DOI: https://doi.org/10.1007/BF01402073

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