Summary
The fibrinolytic activity of 28 cerebral saccular aneurysms from 24 patients and of controls consisting of 10 cerebral arteries has been studied by Todd's autography technique. An increased activity was seen in the minute adventitial vessels and in the endothelium in ruptured cerebral saccular aneurysms, but the aneurysms showed somewhat less activity than the surrounding arteries. Seven patients with subarachnoid haemorrhage had the same increase in fibrinolytic activity in the aneurysmal wall despite antifibrinolytic therapy ante mortem. This finding has been discussed.
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Drake, C. G., Hunt, W. E., Hess, R. M., Surgical risk as related to time of intervention in the repair of intracranial aneurysms. J. Neurosurg.28 (1968), 14–20.
Gomori, G., Aldehyde-fuchsin: A new stain for elastic tissue. Amer. J. Clin. Path.20 (1950), 665–666.
Hassler, O., Morphological studies on the large cerebral arteries with a reference to the aetiology of subarachnoid haemorrhage. Acta Psych, et Neurol. Scand. Suppl. 154,36 (1961), 1–145.
Kwaan, H. C., Astrup, T., Demonstration of cellular fibrinolytic activity by the histochemical fibrin slide technique. Lab. Invest.17 (1967), 140–145.
Mullan, S., Dawley, J., Antifibrinolytic therapy for intracranial aneurysms. J. Neurosurg.28 (1968), 21–23.
Niléhn, J. E., Split products of fibrinogen after prolonged interaction with plasmin. Thrombos. Diathes. haemorrh. (Stuttg.)18 (1967), 89–100.
—, Separation and estimation of “split products” of fibrinogen and fibrin in human serum. Thrombos. Diathes. haemorrh. (Stuttg.)18 (1967), 487–498.
Norlén, G., Thulin, C. A., Experiences with epsilon-aminocaproic acid in neurosurgery. Neurochirurgia (Stuttg.)3 (1967), 81–86.
— —, Antifibrinolytisk behandling vid intrakraniell aneurysm-blödning. Sv. Läk. Tidn.65 (1968), 2910–2912.
— —, The use of antifibrinolytic substances in ruptured intracranial aneurysms. Neurochirurgia (Stuttg.)12 (1969), 7–8.
- - Preliminära erfarenheter av antifibrinolytisk behandling vid intrakraniella blödningar. Antifibrinolytisk Terapi, AB Kabi Stockholm (1970), 73–79.
Pandolfi, M., Histochemistry and assay of plasminogen activator (s.). Europ. J. Clin. Biol. Sci.17 (1972), 254–260.
Todd, A. S., Histological localization of fibrinolysin activator. J. Path. Bact.70 (1959), 281–283.
Tovi, D., and Nilsson, I. M., Increased fibrinolytic activity and fibrin degradation products after experimental intracerebral haemorrhage. Acta Neurol. Scand.48 (1972), 403–415.
—, Thulin, C. A., Ability of tranexamic acid to cross the blood-brain-barrier and its use in patients with ruptured intracranial aneurysms. Acta Neurol. Scand.48 (1972), 257 (abstr.).
—, Nilsson, I. M., Thulin, C. A., Fibrinolysis and subarachnoid haemorrhage. Inhibitory effect of tranexamic acid. A clinical study. Acta Neurol. Scand.48 (1972), 393–402.
— — —, Fibrinolytic activity of the cerebrospinal fluid after subarachnoid haemorrhage. Acta Neurol. Scand.49 (1973), 1–9.
—, Fibrinolytic activity of human brain. A histochemical study. Acta Neurol. Scand.49 (1973), 152–162.
—, The use of antifibrinolytic drugs to prevent early recurrent aneurysmal subarachnoid haemorrhage. Acta Neurol. Scand.49 (1973), 163–175.
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Hassler, O., Fodstad, H. Fibrinolytic activity in the walls of cerebral saccular aneurysms. Acta neurochir 37, 49–55 (1977). https://doi.org/10.1007/BF01401925
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DOI: https://doi.org/10.1007/BF01401925