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Malignant gliomas treated after surgery by combination chemotherapy and delayed radiation therapy

Part II: Tolerance to irradiation after chemotherapy

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Summary

34 patients operated on for malignant gliomas were successively treated by combination chemotherapy with VM26 and CCNU and conventional radiation therapy with an average dosage of 5,800 Rads, six months after surgery. The general and haematological tolerance of delayed irradiation after chemotherapy was satisfactory. Twelve patients developed neurological complications during or after irradiation. The complications were early in 10 cases, and delayed in 2. They were probably due to tumour growth in five cases, and secondary to irradiation in seven. In four of the seven cases the preradiation chemotherapy seemed to potentiate the radiation effect on the central nervous system.

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References

  1. Bouchard, J., Central nervous system. In: Textbook of radiotherapy, 2nd ed., pp. 373–378 (Fletcher, G. H., ed.). Philadelphia: Lea and Febiger. 1973.

    Google Scholar 

  2. Byfield, J. E., Ionizing radiation and vincristine: possible neurotoxic synergism. Radiol. Clin. Biol.41 (1972), 129–138.

    PubMed  Google Scholar 

  3. Cervos-Navarro, J., Der zeitliche Ablauf des akuten Bestrahlungsödems des Gehirns. Acta Neurochir. (Wien)22 (1970), 43–51.

    Google Scholar 

  4. Druckmann, A., Schlafsucht als Folge der Röntgen-Bestrahlung. Strahlentherapie33 (1929), 382–389.

    Google Scholar 

  5. Eyster, E. F., Nielsen, L., Sheline, G. E.,et al., Cerebral radiation necrosis simulating a brain tumour. Case report. J. Neurosurg.39 (1974), 267–271.

    Google Scholar 

  6. Gerstner, L., Jellinger, K., Heiss, W.,et al., Morphologic changes in anaplasic gliomas treated with radiation and chemotherapy. Acta Neurochir. (Wien)36 (1977), 117–138.

    Google Scholar 

  7. Haldorff, B., Radiation damage to the brain. In: Handbook of clinical neurology, Vol. 23, pp. 639–663 (Vinken, P. J., Bruyn, G. W., eds.). Amsterdam-Oxford-New York: North Holland & American Elsevier publishing Co. Inc. 1975.

    Google Scholar 

  8. Haymaker, W., Ibrahim, M. Z., Miquel, J.,et al., Delayed radiation effects in the brains of monkeys exposed to X and gamma rays. J. Neuropath. exp. Neurol.27 (1968), 50–79.

    PubMed  Google Scholar 

  9. Kagan, A. R., Bruce, D. W., Di Chiro, G., Fatal foam cell arteritis of the brain after irradiation for Hodgkin's disease. Stroke2 (1971), 232–238.

    PubMed  Google Scholar 

  10. Klatzo, I., Miquel, J., Tobias, C.,et al., Effects of alpha particle radiation on the brain including vascular permeability and glycogen studies. J. Neuropath. exp. Neurol.20 (1961), 459–483.

    PubMed  Google Scholar 

  11. Kramer, S., The Hazards of therapeutic irradiation of the central nervous system. Clin. Neurosurg.15 (1968), 301–318.

    PubMed  Google Scholar 

  12. Kumar, A. R. V., Hoshino, T., Wheeler, K. T.,et al., Comparative rates of dead tumour cell removal from brain, muscle, subcutaneous tissue and peritoneal cavity. J. nat. Cancer Inst.52 (1974), 1751–1754.

    PubMed  Google Scholar 

  13. Lampert, P. W., Davis, R. L., Delayed effects of radiation on the human central nervous system: early and late delayed reactions. Neurology14 (1964), 912–917.

    PubMed  Google Scholar 

  14. Launay, M., Fredy, D., Merland, J. J.,et al., Narrowing and occlusion of arteries by intracranial tumours. Neuroradiol.14 (1977), 117–126.

    Google Scholar 

  15. Lindgren, M., On tolerance of brain tissue and sensitivity of brain tumours to irradiation. Acta Radiol. Suppl.170 (1958), 1–73.

    Google Scholar 

  16. Marks, J. E., Gado, M., Serial computed tomography of primary tumours following surgery, irradiation and chemotherapy. Radiology125 (1977), 119–125.

    PubMed  Google Scholar 

  17. Martins, A. N., Johnston, J. S., Henry, J. M.,et al., Delayed radiation necrosis of the brain. J. Neurosurg.47 (1977), 336–345.

    PubMed  Google Scholar 

  18. McDonald, L. W., Hayes, T. L., The role of capillaries in the pathogenesis of delayed radionecrosis of brain. Amer. J. Pathol.50 (1967), 745–758.

    Google Scholar 

  19. Miquel, J., Haymaker, W., Brain edema induced by particle and ultraviolet radiation. In: Brain edema, pp. 615–631 (Klatzo, J., Seitelberger, F., eds.). New-York: Springer. 1967.

    Google Scholar 

  20. Monro, P., Mair, W. J. P., Radiation effects on the human central nervous system, 14 weeks after X radiation. Acta Neuropathol. (Berlin)II (1968), 267–274.

    Google Scholar 

  21. Olsson, Y., Klatzo, I., Carsten, A., The effect of acute radiation injury on the permeability and ultrastructure of intracerebral capillaries. Neuropathol. Appl. Neurobiol.I (1975), 59–68.

    Google Scholar 

  22. Painter, M. J., Chutorian, A. M., Hilal, S. K., Cerebrovasculopathy following irradiation in childhood. Neurology25 (1975), 189–194.

    PubMed  Google Scholar 

  23. Pennybacker, J., Russel, D. S., Necrosis of the brain due to radiation therapy. Clinical and pathological observations. J. Neurol. Neurosurg. Psychiat.II (1948), 183–198.

    Google Scholar 

  24. Poisson, M., Philippon, J., Van Effenterre, R.,et al., Cerebral pseudocyst following chemotherapy of glioblastomas. Acta Neurochir. (Wien)39 (1977), 143–149.

    Google Scholar 

  25. Poisson, M., Pouillart, P., Bataini, J. P.,et al., Malignant gliomas treated after surgery by combination chemotherapy and delayed irradiation. Part I: Analysis of results. Acta Neurochir. (Wien)51 (1979), 15–25.

    Google Scholar 

  26. Posner, J. B., Shapiro, W. R., Brain tumours: Current status of treatment and its complications. Arch. Neurol.32 (1975), 781–784.

    PubMed  Google Scholar 

  27. Pouillart, P., Mathe, G., Thao Hoang Thy,et al., Treatment of malignant gliomas and brain metastases in adults with combination of adriamycin, VM 26 and CCNU. Results of a phase II trial. Cancer38 (1976), 1909–1916.

    PubMed  Google Scholar 

  28. Price, R. A., Jameison, P. A., The C.N.S. in childhood leukemia. Cancer35 (1975), 306–318.

    PubMed  Google Scholar 

  29. Roth, J. G., Elvidge, A. R., Glioblastoma multiforme. A clinical survey. J. Neurosurg.17 (1960), 736–750.

    PubMed  Google Scholar 

  30. Rubin, P., Casarett, G. W., Central nervous system. Clinical radiation pathology, Vol. 2, pp. 609–661. Philadelphia, London, Toronto. 1968.

    Google Scholar 

  31. Servo, A., Puranen, M., Moyamoya syndrome as a complication of radiation therapy. J. Neurosurg.48 (1978), 1026–1029.

    PubMed  Google Scholar 

  32. St. Louis, E. L., McLoughlin, M. J., Wortzman, G., Chronic damage to medium and large arteries following radiation. J. Ass. Canad. Radiol.24 (1974), 94–104.

    Google Scholar 

  33. Willson, N., Duffy, P. E., Morphologic changes associated with combined BCNU and radiation therapy in glioblastoma multiforme. Neurology24 (1974), 465–471.

    PubMed  Google Scholar 

  34. Wilson, G. H., Byfield, J., Hanafee, W. N., Atrophy following radiation therapy for the C.N.S. neoplasms. Acta radiol. (Ther. Phys. Biol.)11 (1972), 361–368.

    Google Scholar 

  35. Zeman, W., Samorajski, T., Effects of irradiation on the nervous system. CC Berdjis, Pathology of irradiation, pp. 213–277. Baltimore: Williams and Wilkins. 1971.

    Google Scholar 

  36. Zülch, K. J., Roentgen sensitivity of cerebral tumours and so-called late irradiation necrosis of brain. Acta Radiol. (Ther. Phys. Biol.)8 (1969), 92–110.

    Google Scholar 

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Author notes

  1. M. Poisson

    Present address: Clinique Neurologique de la Salpêtrière, Paris

Authors and Affiliations

  1. Clinique Neurologique de la Salpêtrière, Paris

    R. Mashaly & B. F. Pertuiset

  2. Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, Paris

    J. J. Hauw

  3. Fondation Curie, Paris

    P. Pouillart & J. P. Bataini

  4. Service de Neuroradiologie, Hôpital de la Pitié, Paris, France

    J. Metzger

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  1. M. Poisson
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  2. J. J. Hauw
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  4. J. P. Bataini
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  5. R. Mashaly
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  7. J. Metzger
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Poisson, M., Hauw, J.J., Pouillart, P. et al. Malignant gliomas treated after surgery by combination chemotherapy and delayed radiation therapy. Acta neurochir 51, 27–42 (1979). https://doi.org/10.1007/BF01401792

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