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Aneurysmal bleeding. A plea for early surgery in good-risk patients

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Summary

From 1985 onwards we have aimed at operating on good-risk patients, i.e., those graded I–III on the WFNS SAH Scale, within 3 days after the aneurysmal bleed. We report on a series of 100 consecutive operations for saccular aneurysm, covering a period of 51/2 years.

Early operations (in the above sense) were done in 57 good-risk but otherwise unselected patients. After a one year follow-up, 47 of them (82%) were found to have made a good recovery (Glasgow Outcome Score I). The outcome of (mostly early) surgery in 15 selected poor-risk patients (WFNS SAH Scale IV and V) was much less favourable.

Late surgery (4 or more days after SAH) was performed in 28 good-risk patients, most of whom had been admitted several days or weeks after the bleeding. Almost all of these patients had a good outcome.

It is argued that the known management results of delayed surgery, which during the deliberately chosen interval exposes the patient to the risk of rebleeding and vasospasm, have by now been surpassed by those of early surgery. However excellent the surgical results of delayed operations may be, early operation should become the treatment of choice in good-risk patients.

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References

  1. Adams HP Jr, Kassell NF, Kongable GA, Torner JC (1988) Intracranial operations within seven days of aneurysmal subarachnoid hemorrhage; results in 150 patients. Arch Neurol 45: 1065–1069

    PubMed  Google Scholar 

  2. Allen GS, Ahn HS, Preziosi TJ, Lavik PJ, Rosenbloom SB, Kelly PL, Weir BK, Crabbe RA, Battye R, Boone SC, Chou SN, Dorsey FC, Ingram CR, Mellits DE, Bertsch LA, Voisxert DPJ, Huntley MB, Johnson RK, Strom JA, Transon CR (1983) Cerebral arterial spasm — a controlled trial of nimodipine in patients with subarachnoid hemorrhage. N Engl J Med 308: 619–624

    PubMed  Google Scholar 

  3. Ausman JI, Diaz FG, Malik GM, Fielding AS, Son CS (1985) Current management of cerebral aneurysms: is it based on facts or myths. Surg Neurol 24: 625–635

    PubMed  Google Scholar 

  4. Chyatte D, Fode NC, Sundt TM Jr (1988) Early versus late intracranial aneurysm surgery in subarachnoid hemorrhage. J Neurosurg 69: 326–331

    PubMed  Google Scholar 

  5. Da Pian R, Pasqualin A, Scienza R, Licata C, Cavazzani P (1983) A preliminary report on early surgery for bleeding intracranial aneurysms. J Neurosurg Sci 27: 1–8

    PubMed  Google Scholar 

  6. Deruty R, Mottolese C, Pelissou-Guyotat I, Soustiel JF (1991) Management of the ruptured intracranial aneurysm — early surgery, late surgery, or modulated surgery? Personal experience based upon 468 patients admitted in two periods (1972–1984 and 1985–1989). Acta Neurochir (Wien) 113: 1–10

    Google Scholar 

  7. Drake CG (1981) Management of cerebral aneurysm. Stroke 12: 273–283

    PubMed  Google Scholar 

  8. Gilsbach JM, Harders AG, Eggert HR, Hornyak ME (1988) Early aneurysm surgery: a 7 year clinical practice report. Acta Neurochir (Wien) 90: 91–102

    Google Scholar 

  9. Hailey EC Jr, Kassell NF, Torner JC, the participants (1992) The international cooperative study on the timing of aneurysm surgery. The North American Experience. Stroke 23: 205–214

    PubMed  Google Scholar 

  10. Hunt WE, Kassell N, Pertuiset B, Sano K, Teasdale G, de Villier JC, Drake CG (1988) Report of the World Federation of Neurosurgical Surgeons Committee on a Universal Subarachnoid Hemorrhage Grading Scale. J Neurosurg 68: 985–986

    PubMed  Google Scholar 

  11. Hijdra A, Braakman R, van Gijn J, Vermeulen M, van Crevel Th (1987) Aneurysmal subarachnoid hemorrhage — complications and outcome in a hospital population. Stroke 18: 1061–1067

    PubMed  Google Scholar 

  12. Jannett B, Bond M (1975) Assessment of outcome after severe brain damage: a practical scale. Lancet i: 480–484

    Google Scholar 

  13. Kassell NF, Peerless SJ, Durward QJ, Beck DW, Drake CG, Adams HP (1982) Treatment of ischemic deficits from vasospasm with intravascular volume expansion and induced arterial hypertension. Neurosurgery 11: 337–341

    Google Scholar 

  14. Kassell NF, Torner JC (1983) Aneurysmal rebleeding: a preliminary report from the cooperative aneurysm study. Neurosurgery 13: 479–481

    Google Scholar 

  15. Kassell NF, Torner JC, Haley EC Jr, Jane JA, Adams HP, Kongable GL, and participants (1990) The international cooperative study on the timing of aneurysm surgery. Part 1: overall management results. J Neurosurg 73: 18–36

    PubMed  Google Scholar 

  16. Kassell NF, Torner JC, Jane JA, Hailey ECJ, Adams HP and participants (1990) The international cooperative study on the timing of aneurysm surgery. Part 2: surgical results. J Neurosurg 73: 37–47

    Google Scholar 

  17. Ljunggren B, Brandt L, Kågström E, Sundbärg G (1981) Results of early operations for ruptured aneurysms. J Neurosurg 54: 473–479

    PubMed  Google Scholar 

  18. Ljunggren B, Brandt L, Sundbärg G, Säveland H, Cronqvist S, Stridbeck H (1982) Early management of aneurysmal subarachnoid hemorrhage. Neurosurgery 11: 412–418

    PubMed  Google Scholar 

  19. Ljunggren B, Säveland H, Brandt L, Zygmunt S (1985) Early operation and overall outcome in aneurysmal subarachnoid hemorrhage. J Neurosurg 62: 547–551

    PubMed  Google Scholar 

  20. Medlock MD, Dulebohn SC, Elwood PW (1992) Prophylactic hypervolaemia without calcium charnel blockers in early aneurysm surgery. Neurosurgery 30: 12–16

    PubMed  Google Scholar 

  21. Mee E, Dorrance D, Lowe D, Neil-Dwyer G (1988) Controlled study of nimodipine in aneurysm patients treated early after subarachnoid hemorrhage. Neurosurgery 22: 484–491

    PubMed  Google Scholar 

  22. Muizelaar JP, Becker D (1986) Induced hypertension for the treatment of cerebral ischaemia after subarachnoid hemorrhage. Direct effect on cerebral bloodflow. Surg Neurol 25: 317–325

    PubMed  Google Scholar 

  23. Öhman J, Heiskanen O (1988) Effect of nimodipine on the outcome of patients after aneurysmal subarachnoid hemorrhage and surgery. J Neurosurg 69: 683–686

    PubMed  Google Scholar 

  24. Öhman J, Heiskanen O (1989) Timing of operation for ruptured supratentorial aneurysms: a prospective randomized study. J Neurosurg 70: 55–60

    Google Scholar 

  25. Öhman J, Servo A, Heiskanen O (1991) Long term effects of nimodipine on cerebral infarcts and outcome after aneurysmal subarachnoid hemorrhage and surgery. J Neurosurg 74: 8–13

    Google Scholar 

  26. Öhman J, Servo A, Heiskanen O (1991) Risk factors for cerebral infarction in good-grade patients after aneurysmal subarachnoid hemorrhage and surgery: a prospective study. J Neurosurg 74: 14–20

    PubMed  Google Scholar 

  27. Pickard JD, Murray GD, Illingworth R, Shaw MDM, Teasdale GM, Foy PM, Humphrey PRD, Lang DA, Nelson R, Richards P, Sinar J, Baley S, Skene A (1989) Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid hemorrhage. British aneurysm nimodipine trial. BMJ 298: 636–642

    PubMed  Google Scholar 

  28. Ropper AH, Zervas NT (1984) Outcome one year after SAH from cerebral aneurysm. Management, morbidity, mortality and functional status in 112 consecutive good-risk patients. J Neurosurg 60: 909–915

    PubMed  Google Scholar 

  29. Säveland H, Hillman J, Brandt L, Edner G, Jakobsson KE, Algers G (1992) Overall outcome in aneurysmal subarachnoid hemorrhage. A prospective study from neurosurgical units in Sweden during a 1-year period. J Neurosurg 76: 729–734

    Google Scholar 

  30. Seiler RW, Reulen HJ, Huber P, Grolimund R, Ebeling U, Steiger HJ (1988) Outcome of aneurysmal subarachnoid hemorrhage in a hospital population: a prospective study including early operation, intravenous nimodipine and transcranial Doppler ultrasound. Neurosurgery 23: 598–604

    Google Scholar 

  31. Seifert V, Stolke V, Trost HA (1988) Timing of aneurysm surgery. Comparison of results of early and delayed surgical intervention. Eur Arch Psychiatry Neurol Sci 237: 291–297

    PubMed  Google Scholar 

  32. Shephard RH (1983) Ruptured cerebral aneurysms: early and late prognosis with surgical treatment — a personal series, 1958–1980. J Neurosurg 59: 6–15

    PubMed  Google Scholar 

  33. Shibuya M, Suzuki Y, Sugita K, Saito I, Sasaki T, Takakura K, Nagat I, Kikuchi H, Takemae T, Hidaka H, Nakashima M (1992) Effect of AT 877 on cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Results of a prospective placebocontrolled double-blind trial. J Neurosurg 76: 571–577

    PubMed  Google Scholar 

  34. Solomon RA, Fink ME, Lennihan L (1988) Early aneurysm surgery and prophylactic hypervolemic hypertensive therapy for the treatment of aneurysmal subarachnoid hemorrhage. Neurosurgery 23: 699–704

    PubMed  Google Scholar 

  35. Solomon RA, Onesti ST, Klebanoff L (1991) Relationship between the timing of aneurysm surgery and the development of delayed cerebral ischaemia. J Neurosurg 75: 56–61

    PubMed  Google Scholar 

  36. Sundt TM Jr, Kobayashi S, Fode NC, Whisnant JP (1982) Results and complications of surgical management of 809 intracranial aneurysms in 722 cases. J Neurosurg 56: 753–765

    PubMed  Google Scholar 

  37. Suzuki J, Onuma T, Yoshimoto T (1979) Results of early operations on cerebral aneurysms. Surg Neurol 11: 407–412

    PubMed  Google Scholar 

  38. Taneda M (1982) Effect of early operation for ruptured aneurysms on prevention of delayed ischemic symptoms. J Neurosurg 57: 622–628

    PubMed  Google Scholar 

  39. Taylor B, Harries P, Bullock R (1991) Factors affecting outcome after surgery for intracranial aneurysms in Glasgow. Br J Neurosurg 5: 591–600

    PubMed  Google Scholar 

  40. Vermeulen M, Lindsay KW, Murray GD, Cheah F, Hijdra A, Muizelaar JP, Schannong M, Teasdale GM, van Crevel H, van Gijn J (1984) Antifibrinolytic treatment in subarachnoid hemorrhage. N Engl J Med 311: 432–437

    PubMed  Google Scholar 

  41. Weir B, Aronyk K (1981) Managment mortality and the timing of surgery for supratentorial aneurysm. J Neurosurg 54: 146–150

    Google Scholar 

  42. Wilkins RH (1981) Update — subarachnoid hemorrhage and saccular intracranial aneurysms. Surg Neurol 15: 92–101

    PubMed  Google Scholar 

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Thomeer, R.T.W.M., Taal, J.C.W., Voormolen, J.H.C. et al. Aneurysmal bleeding. A plea for early surgery in good-risk patients. Acta neurochir 128, 126–131 (1994). https://doi.org/10.1007/BF01400662

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