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ICP Dependent changes of CSF outflow resistance

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Summary

CSF outflow resistance was studied in cats using the lumbar infusion tests. Different infusion rates were applied from 0.012 to 1.8 ml/min. ICP level obtained during infusions varied from 8.9 ± 3.0 to 144.0 ± 25.7 mmHg. The calculated resistance (R) values were within 75.2 ± 14.4 to 255.6 ± 71.2 mm Hg/ml/min.

The relation between ICP and R are characterized by a curve which can be divided into three parts. First R rises until an ICP level of about 20 mmHg is reached, then R decreases fast until the ICP value is about 50 mmHg, a further drop is much slower and the ICP/ R curve becomes almost parallel to the ICP axis. The possible reasons for the ICP dependent changes of R as well as the clinical importance of the results obtained are discussed.

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Authors and Affiliations

  1. Neurosurgical Clinic, Polish Academy of Sciences, Medical Research Centre, Warsaw, Poland

    K. Tychmanowicz, Z. Czernicki, G. Pawłowski & G. Stępińska

Authors
  1. K. Tychmanowicz
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  2. Z. Czernicki
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  3. G. Pawłowski
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  4. G. Stępińska
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Tychmanowicz, K., Czernicki, Z., Pawłowski, G. et al. ICP Dependent changes of CSF outflow resistance. Acta neurochir 117, 44–47 (1992). https://doi.org/10.1007/BF01400634

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