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Colonic inhibition of gastric secretion in man

Digestive Diseases and Sciences volume 26, pages 195–201 (1981)Cite this article

Abstract

The effect of colonic infusion of various solutions on submaximal pentagastrin-stimulated gastric secretion was determined in healthy volunteers. Hypertonic (823 mOsm/kg) glucose, mannitol, and saline, and also isotonic glucose significantly induced a marked and sustained inhibition of gastric acid secretion of 74%, 66%, 79%, and 54%, respectively. A similar degree of inhibition was obtained for pepsin secretion with hypertonic glucose and mannitol. Isotonic triglycerides and isotonic saline solutions had no significant effect on gastric acid secretion. Hypertonic glucose, mannitol, and saline infusions significantly increased plasma concentrations of enteroglucagon, whereas other solutions had no effect. No correlation, however, was found between the percentage rise of enteroglucagon and the percentage inhibition of gastric secretion obtained from any of the three hypertonic solutions. The physiological significance of these findings remains to be established.

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Affiliations

  1. Research Unit on Physiopathology of Digestion (INSERM U54), Hopital Saint-Lazare, 107 bis, rue du Faubourg Saint-Denis, 75010, Paris, France

    R. Jian, H. S. Besterman, D. L. Sarson, C. Aymes, J. Hostein, S. R. Bloom & J. C. Rambaud

  2. Department of Medecine Royal Postgraduate Medical School, Hammersmith Hospital, W12 0HS, London

    R. Jian, H. S. Besterman, D. L. Sarson, C. Aymes, J. Hostein, S. R. Bloom & J. C. Rambaud

Authors
  1. R. Jian
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  2. H. S. Besterman
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  3. D. L. Sarson
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  4. C. Aymes
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  5. J. Hostein
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  6. S. R. Bloom
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  7. J. C. Rambaud
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Additional information

This work was supported by a grant from the INSERM (No. 16 75 39) and the Wellcome Trust.

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Jian, R., Besterman, H.S., Sarson, D.L. et al. Colonic inhibition of gastric secretion in man. Digest Dis Sci 26, 195–201 (1981). https://doi.org/10.1007/BF01391629

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  • DOI: https://doi.org/10.1007/BF01391629

Keywords

  • Glucose
  • Triglyceride
  • Mannitol
  • Saline Solution
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