Skip to main content
SpringerLink
Log in

Severe copper deficiency due to excessive use of an antacid combined with pyloric stenosis

Digestive Diseases and Sciences volume 27, pages 859–861 (1982)Cite this article

Summary

A case of copper deficiency due to excessive use of an antacid combined with pyloric stenosis is described. It was demonstrated in anin vitro experiment that the addition of the antacid to a coppercontaining artificial gastric fluid resulted in a decrease of the copper concentration, presumably due to precipitation of copper oxydes. Copper deficiency disappeared after discontinuing of the antacid and beginning oral copper therapy.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

USD 39.95

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

References

  1. Labery ME, Gubler CJ, Chase MS: Studies on copper metabolism II. Haematologic manifestations of copper deficiency in swine. Blood 7:1053–1073, 1952

    PubMed  Google Scholar 

  2. Cartwright GE, Wintrobe MM: The question of copper deficiency in man. Am J Clin Nutr 15:94–110, 1974

    Google Scholar 

  3. Cordano A, Beartl JM, Graham GG: Copper deficiency in infancy. Pediatrics 34:324–336, 1964

    PubMed  Google Scholar 

  4. Cordano A, Placko RP, Graham GG: Hypocupremia and neutropenia in copper deficiency. Blood 28:280–283, 1966

    PubMed  Google Scholar 

  5. Ashkenazi A, Levin S, Djaldetti M, Fishel E, Benvenisti D: The syndrome of neonatal copper deficiency. Pediatrics 52:525–533, 1973

    PubMed  Google Scholar 

  6. Karpel JT, Peden VH: Copper deficiency in long-term parenteral nutrition. J Pediatr 80:32–36, 1972

    PubMed  Google Scholar 

  7. Vilter RW, Bozian RC, Hess EV, Zellner DC, Petering HG: Manifestations of copper deficiency in a patient with systemic sclerosis on intravenous hyperalimentation. N Engl J Med 291:188–191, 1974

    PubMed  Google Scholar 

  8. Dunlap WM, Watson James III G, Hume DM: Anemia and neutropenia caused by copper deficiency. Ann Intern Med 80:470–476, 1974

    PubMed  Google Scholar 

  9. Prasad AS, Brewer GJ, Schoomaker EB, Rabbani P: Hypocupremia induced by zinc therapy in adults. J Am Med Assoc 240:2166–2168, 1978

    Google Scholar 

  10. Porter KG, McMaster D, Elmer ME, Love AHG: Anemia and low serum copper during zinc therapy. Lancet 2:774, 1977

    Google Scholar 

  11. Holmberg CG, Laurell CB: Oxidase reactions in human plasma caused by caeruloplasmin. Scand J Clin Lab Invest 3:103–107, 1951

    PubMed  Google Scholar 

  12. Curzon G, O'Reilly S: A coupled iron-caeruloplasmin oxidation system. Biochem Biophys Res Comm 2:284–286, 1960

    Google Scholar 

  13. Osaki S, Johnson DA, Frieden E: The positive significance of the ferrous oxidase activity of ceruloplasmin in normal human serum. J Biol Chem 241:2746–2751, 1966

    PubMed  Google Scholar 

  14. Lee GR, Nacht S, Lukens JN, Cartwright GE: Iron metabolism in copper-deficient swine. J Clin Invest 47:2058–2069, 1968

    PubMed  Google Scholar 

  15. Ragan HA, Nacht S, Lee GR, Bishop CR, Cartwright GE: Effect of ceruloplasmin on plasma iron in copper-deficient swine. Am J Physiol 217:1320–1323, 1969

    PubMed  Google Scholar 

  16. Roeser HP, Lee GR, Nacht S, Cartwright GE: The role of ceruloplasmin in iron metabolism. J Clin Invest 49:2408–2417, 1970

    PubMed  Google Scholar 

  17. Lee GR, Williams DM, Cartwright GE: Role of copper in iron metabolism and heme biosynthesis.In Trace Elements in Human Health and Disease, Volume I, AS Prasad, D Oberleas (eds). New York, Academic Press, 1976, pp 373–390

    Google Scholar 

  18. Earl CJ, Moulton MJ, Selverstone B: Metabolism of copper in Wilson's disease and in normal subjects. Am J Med 17:205–213, 1954

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Hematology and Gastroenterology, Department of Internal Medicine and Department of Clinical Pharmacy, University Hospital St Radboud, Nijmegen, The Netherlands

    Piet M. Van Kalmthout MD, Leopold G. J. Engels MD, Hans H. Bakker PharmD & Jos T. M. Burghouts MD

Authors
  1. Piet M. Van Kalmthout MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Leopold G. J. Engels MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hans H. Bakker PharmD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jos T. M. Burghouts MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Van Kalmthout, P.M., Engels, L.G.J., Bakker, H.H. et al. Severe copper deficiency due to excessive use of an antacid combined with pyloric stenosis. Digest Dis Sci 27, 859–861 (1982). https://doi.org/10.1007/BF01391380

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01391380

Keywords

search

Navigation