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Adrenergic modulation of gastric inhibitory polypeptide secretion in man

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Abstract

In order to examine the effect of adrenergic influences on gastric inhibitory polypeptide (GIP) secretion, a series of glucose tolerance tests was carried out in seven healthy volunteers during intravenous infusion of epinephrine (6 μg/min), epinephrine plus phentolamine (5 mg stat+0.5 mg/min), epinephrine plus propranolol (5 mg stat+0.08 mg/min), and saline. No drug infusion modified fasting GIP levels. Alpha-adrenergic stimulation (epinephrine+propranolol) significantly reduced the GIP response (P<0.02) and completely inhibited the insulin response (P<0.005) to oral glucose, compared with control experiments. Epinephrine alone and epinephrine+phentolamine did not influence glucose-stimulated GIP. These results suggest the possibility that the adrenergic nervous system may have a role in the regulation of GIP secretion in man.

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Authors and Affiliations

  1. Division of Gastroenterology and Metabolism, University of Göttingen, Göttingen, FRG

    M. Salera MD, R. Ebert MD, P. Giacomoni MD, L. Pironi MD, S. Venturi MD, R. Corinaldesi MD, M. Miglioli MD & L. Barbara MD

  2. Clinica Medica III e Gastroenterologia, Policlinico S. Orsola, Via Massarenti 9, 40136, Bologna, Italy

    M. Salera MD, P. Giacomoni MD, L. Pironi MD, S. Venturi MD, R. Corinaldesi MD, M. Miglioli MD & L. Barbara MD

Authors
  1. M. Salera MD
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  2. R. Ebert MD
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  3. P. Giacomoni MD
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  4. L. Pironi MD
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  5. S. Venturi MD
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  7. M. Miglioli MD
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  8. L. Barbara MD
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Salera, M., Ebert, R., Giacomoni, P. et al. Adrenergic modulation of gastric inhibitory polypeptide secretion in man. Digest Dis Sci 27, 794–800 (1982). https://doi.org/10.1007/BF01391372

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  • DOI: https://doi.org/10.1007/BF01391372

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