Summary
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1.
The development of the embryonic lethal mutantX 27 was studied by means of serial sections and by observations on living embryos.
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2.
The embryos reaches a late stage of development, and survives after the time at which normal embryos hatch.
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3.
The earliest observable effect of the factor is upon the first stage of gastrulation, in which the formation of the ventral furrow is disturbed.
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4.
Some abnormalities of the final embryo, especially certain deformations of the hind-gut and the nervous system, originate in mechanical disturbances arising from the abnormalities in gastrulation.
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5.
Other abnormalities do not originate in this way, but are due to defective cell differentiation: the gut remains sac-like, the ectoderm remains unsegmented, and the musculature of the body wall is undeveloped.
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6.
It is probable that the failure of the musculature of the body wall to develop follows from the absence of segmentation in the hypoderm, and that a type of inductive mechanism is involved.
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Abbreviations
- AMG:
-
anterior mid-gut
- AP:
-
apodeme
- BNB:
-
brain neuroblasts
- BR:
-
brain
- EM:
-
embryonic membrane
- HG:
-
hind-gut
- HY:
-
hypodermis
- IGB:
-
irregular germ band
- MCN:
-
median cells of nervous system
- MES:
-
mesoderm
- MG:
-
mid-gut
- MSN:
-
mesodermal mesenchyme
- MYB:
-
myoblasts
- OES:
-
oesophagus
- PH:
-
pharynx
- PHM:
-
pharyngeal muscles
- PMG:
-
posterior mid-gut
- PRO:
-
proctodaeal opening;
- PV:
-
proventriculus
- PVF:
-
persistent ventral furrow
- SGI:
-
salivary gland invagination
- VNS:
-
ventral nervous system
- Y:
-
yolk
References
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Ede, D.A. Studies on the effects of some genetic lethal factors on the embryonic development ofDrosophila melanogaster . W. Roux' Archiv f. Entwicklungsmechanik 149, 88–100 (1956). https://doi.org/10.1007/BF01382508
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DOI: https://doi.org/10.1007/BF01382508