Rheumatology International

, Volume 16, Issue 6, pp 237–240 | Cite as

Type II collagen serology: a guide to clinical responsiveness to oral tolerance?

  • U. Gimsa
  • N. A. Mitchison
  • J. Sieper
  • J. Braun
Original Article


A double-blind placebo-controlled randomized trial of oral collagen type II (CII) treatment in rheumatoid arthritis was completed in Berlin. Anti-CII antibody titres were measured before and after the treatment. They showed that: (1) the titre prior to treatment did not identify a responder subgroup, (2) the treatment reduced CII antibody titres, but only in those patients making a clinical response and (3) administration of 10 mg CII per day reduced the titre in these subsets more effectively than 1 mg per day. Although the data are limited, they suggest that a titre drop may be useful for identifying those patients who respond to this form of treatment and that the drop may be a valid parameter for detecting the impact of the treatment on the immune system.

Key words

Collagen II Rheumatoid arthritis Antibodies Oral tolerance 


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Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • U. Gimsa
    • 1
  • N. A. Mitchison
    • 1
  • J. Sieper
    • 2
  • J. Braun
    • 2
  1. 1.Deutsches Rheuma-Forschungs-Zentrum BerlinBerlinGermany
  2. 2.Department of Medicine, RheumatologyKlinikum Benjamin FranklinBerlinGermany

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