Rheumatology International

, Volume 16, Issue 6, pp 231–235 | Cite as

Prevention of neutrophil apoptosis by monosodium urate crystals

  • T. Akahoshi
  • T. Nagaoka
  • R. Namai
  • N. Sekiyama
  • H. Kondo
Original Article


The effects of monosodium urate (MSU) crystals on apoptosis of cultured peripheral blood neutrophils were investigated. MSU crystals at low concentrations decreased the rate of spontaneous apoptosis of neutrophils in a dose- and time-dependent manner. The culture supernatant of MSU crystal stimulated neutrophils also promoted a delay in neutrophil apoptosis. MSU crystals at higher concentrations rapidly caused cell lysis. These findings indicated that MSU crystals are capable of amplifying the inflammatory responses of gouty arthritis by decreasing the rates of neutrophil apoptosis at lower concentrations and inducing cell lysis at higher concentrations.

Key words

Neutrophils Apoptosis Monosodium urate crystals Gout 


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Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • T. Akahoshi
    • 1
  • T. Nagaoka
    • 1
  • R. Namai
    • 1
  • N. Sekiyama
    • 1
  • H. Kondo
    • 1
  1. 1.Department of Internal MedicineKitasato University School of MedicineKanagawaJapan

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