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Biotransformation of benzoylheteratisine in the animal organism and biological activity of its main metabolite

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The metabolism of the alkaloid benzoylheteratisine in the animal organism has been studied and it has been shown that its main metabolic product is heteratisine. In experiments on various models of arrhythmia the antiarrhythmic activity of heteratisine proved to be lower than that of benzoylheteratisine.

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References

  1. F. N. Dzhakhangirov, Zh. Kh. Kuzibaeva, and Zh. Rezhepov, in: First Congress on Internal Medicine of the Countries of Central Asia, Abstract of Lectures [in Russian], Tashkent (1994), p. 34.

  2. Ya. V. Rashkes, E. G. Mil'grom, and Yu. M. Mil'grom, Khim. Prir. Soedin., 384 (1993).

  3. E. G. Sirotenko, Ya. V. Rashkes, and S. K. Usmanova, Khim. Prir. Soedin., 532 (1989).

  4. F. N. Dzgakhangirov, E. G. Sirotenko, and Ya. V. Rashkes, Dokl. Akad. Nauk RUz, No. 8, 44 (1989).

  5. F. N. Dzhakhangirov and F. S. Sadritdinov, Dokl. Akad. Nauk UzSSR, No. 3, 50 (1977).

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Authors
  1. Zh. Kh. Kuzibaeva
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  2. F. N. Dzhakhangirov
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  3. E. G. Mil'grom
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Additional information

Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, fax (3712) 89 14 75. Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 391–393, May–June, 1996. Original article submitted March 4, 1996.

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Kuzibaeva, Z.K., Dzhakhangirov, F.N. & Mil'grom, E.G. Biotransformation of benzoylheteratisine in the animal organism and biological activity of its main metabolite. Chem Nat Compd 32, 372–373 (1996). https://doi.org/10.1007/BF01372343

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  • DOI: https://doi.org/10.1007/BF01372343

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