Pediatric Surgery International

, Volume 12, Issue 8, pp 599–602 | Cite as

Actual half-life of alpha-fetoprotein as a prognostic tool in pediatric malignant tumors

  • S. J. Han
  • S. -Y. Yoo
  • S. H. Choi
  • E. H. Hwang
Original Article


In a retrospective study, the prognostic value of monitoring the decay of alpha-fetoprotein (AFP) was assessed. Serum AFP was determined serially in 18 children with malignant germ-cell or hepatic tumors: 7 endodermal sinus tumor, 3 embryonal carcinoma, 5 malignant teratoma, 2 hepatoblastomas, and 1 hepatocellular carcinoma. The actual half-life (AHL) of AFP was computed after surgical resection of the tumor. In group 1, which had complete resection and no recurrence during follow-up (n = 13), the AHL of AFP was 4.0 ± 0.9 days. In group 2, which had incomplete resection or recurrence during follow-up (n = 5), the AHL of AFP was 24.8 ± 20 days, significantly longer than that of group 1 (P = 0.0026). The increased AHL of AFP indicated residual active tumor after surgical resection. The AHL of AFP may be more sensitive than serial monitoring of AFP in detecting preclinical recurrence after surgical resection of AFP-secreting tumors. Treatment strategies can be based on AFP clearance, and prospective clinical trials are warranted.

Key words

Actual half-life Alpha-fetoprotein Malignant germ-cell tumor Hepatic malignancy 


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  1. 1.
    Gitlin D, Boesman M (1966) Serum alpha-fetoprotein, albumin and gamma G-globulin in the human conceptus. J Clin Invest 45: 1826–1838PubMedGoogle Scholar
  2. 2.
    Kohn J (1978) The dynamics of serum alpha-fetoprotein in the course of testicular teratoma. Scand J Immunol 8: 103–107Google Scholar
  3. 3.
    Kurman RJ, Scardino PT, McIntire KR (1977) Cellular localization of alpha-fetoprotein and human chorionic gonadotropin in germ cell tumors of testis using an indirect inununoperoxidase technique. Cancer 40: 2136–2151PubMedGoogle Scholar
  4. 4.
    Lange PH, Vogelsang NJ, Goldman A (1982) Marker half-life analysis as prognostic tool in testicular cancer. J Urol 128: 708–711PubMedGoogle Scholar
  5. 5.
    Nichols CR, Fox EP (1991) Extragonadal and pediatric germ cell tumors. Hematol Oncol Clin North Am 5: 1189–1209PubMedGoogle Scholar
  6. 6.
    Norgaard-Pedersen B (1976) Human-alpha-fetoprotein. A review of recent methodological and clinical studies. Scand J Immunol 5: 1–45PubMedGoogle Scholar
  7. 7.
    Serov SF, Scully RE, Sobin LH (1973) Histological typing of ovarian tumors. International histologic classification of tumors, no. 9. World Health Organization, GenevaGoogle Scholar
  8. 8.
    Skipper HE, Schabel FM (1973) Quantitative and cytokinetic studies in experimental tumor models. In: Frei E, Holland JF (eds) Cancer medicine. Lea & Febiger, Philadelphia, pp 554–612Google Scholar
  9. 9.
    Thompson DK, Haddow JE (1979) Serial monitoring of serum alpha-fetoprotein and chorionic gonadotropin in males with germ cell tumors. Cancer 43: 1820–1829PubMedGoogle Scholar
  10. 10.
    Vogelzang NJ, Lange PH, Goldman A (1982) Acute changes of α-fetoprotein and human chorionic gonadotropin during induction chemotherapy of germ cell tumors. Cancer Res 42: 4855–4861PubMedGoogle Scholar
  11. 11.
    Wilmore DW (1991) Homeostasis — bodily changes in trauma and surgery. In: Sabiston DC Jr (ed) Textbook of surgery, 14th edn. Saunders, Philadelphia, pp 19–33Google Scholar
  12. 12.
    Wu JT, Book L, Sudar K (1981) Serum alpha fetoprotein (AFP) levels in normal infants. Pediatr Res 15: 50–52PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • S. J. Han
    • 1
  • S. -Y. Yoo
    • 2
  • S. H. Choi
    • 1
  • E. H. Hwang
    • 1
  1. 1.Department of Pediatric SurgeryYonsei University College of MedicineSeodaemoon-Ku, SeoulKorea
  2. 2.Department of SurgeryYonsei University Wonju College of MedicineWonjuKorea

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