Summary
Two different Spanish populations, one from Galicia (NW Spain) and the other from the rest of Spain, have been analyzed at three different hypervariable loci (YNH24, MS43a and MS31) using the EDNAP electrophoretic protocol andHinfI as restriction enzyme. Although the “rest of Spain” population is a clearly stratified population using classical blood groups, no evidence of stratification for these loci has been found and the differences to the Galician population were not significant, which suggests that a common Spanish population database could be possible. A semiparametric model is proposed for estimating frequencies, using the smoothed cross-validation of Hall et al. (1992) to calculate the size of the window utilized.
Zusammenfassung
Zwei unterschiedliche spanische Populationen -aus Galizien (Nordwest-Spanien) und die andere aus dem restlichen Spanien - wurden auf drei hypervariable Loci (YNH24, MS43a und MS31) untersucht. Die Methode entsprach dem EDNAP-Protokoll,Hinf wurde als Restriktionsenzym genommen. Obwohl die Population „restliches Spanien” in der klassischen Blutgruppenserologie eine deutlich geschichtete Population darstellt, ist kein Beweis für eine Schichtung dieser Loci gefunden worden, und die Unterschiede zur Bevölkerung von Galizien waren nicht significant. Dies legt nahe, daß eine allgemeine spanische Populationsdatenbank möglich sein könnte. Ein halb-parametrisches Modell wird vorgeschlagen, um die Frequenzen zu schätzen. Dieses benutzt die geglättete Kreuz-Validierung von Hall et al. (1992), um die Größe des benutzten Fensters zu berechnen.
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Valverde, E., Cabrero, C., Cao, R. et al. Population genetics of three VNTR polymorphisms in two different Spanish populations. Int J Leg Med 105, 251–256 (1993). https://doi.org/10.1007/BF01370381
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DOI: https://doi.org/10.1007/BF01370381