Abstract
In vitro andin vivo experiments were carried out with medium-chain glycerides.In vitro, cholesterol gallstones were rapidly dissolved by medium-chain glycerides; control experiments with saline solution failed to modify the size of the stones.In vivo, medium-chain glycerides were instilled through an, intraductal tube in 12 patients with retained bile duct stones. Perfusions lasted 2–10 days. After perfusion, stones disappeared in six cases, were reduced in size in one case, and remained unchanged in five cases. In five cases, nausea, vomiting, diarrhea, or pain were observed. Medium-chain glyceride infusion rapidly dissolves cholesterol gallstones, but is commonly associated with mild to servre side effects.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Frelding JF: The management of ductal stones in the biliary tree. Ir J Med Sci 148:101–106, 1979
Burhenne HJ: Nonoperative retained biliary tract stone extraction. Am J Roentgenol 177:866, 1973
García-Romero E, López-Centeno M, Arcelus IM: Dissolution of human gallstone with clofibrate J Surg Res 24:62–69, 1978
Chary S: Dissolution of retained bile duct stones using heparin Br J Surg 64:347–351, 1977
Wilson D, Delaney JP, Duane WC, Pries JM, Silvis SE, Vennes JA: Choledocho-lithiasis. Gastroenterology 75:120–128, 1978
Landsford C, Mehta S, Kern F Jr: The treatment of retained stones in the common bile duct with sodium cholate infusion. Gut 15:48–51, 1974
Narat JK, Cipolla AF: Fragmentation and dissolution of gallstones by chloroform. Arch Surg 51:51–54, 1945
Thistle JL, Carlson GL, Hofman AF, Babayan VK: Medium chain glycerides rapidly dissolve cholesterol gallstonein vitro. Gastroenterology 72:1141, 1977 (abstract)
Thistle JL, Carlson GL, Hofmann AF, La Russo NF, MacCarty RL, Flynn GL, Higuchi WL, Babayan VK: Monooctanoin a dissolution agent for retained cholesterol bile duct stones: Physical properties and clinical application. Gastroenterology 78:1016–1022, 1980
Zlaltkis A, Zak B, Boyle A: A new method for the direct determination of serum cholesterol. J Lab Clin Med 41:488–490, 1953
Gil SD: Lagarriga AJ, López PJ, Carbajal RA: Un nuevo apara to para evaluar substancias litoliticas. Rev San Mil (Mex) 31:134–137, 1977
Way LW, Admirand WH, Dunphy JE: Management of choledolithiasis. Ann Surg 176:347–359, 1972
Sohrabi A, Max MH, Hershey CH: Cholate sodium infusion for retained common bile duct stones. Arch Surg 114:1169–1172, 1979
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Uribe, M., Uscanga, L., Farca, S. et al. Dissolution of cholesterol ductal stones in the biliary tree with medium-chain glycerides. Digest Dis Sci 26, 636–640 (1981). https://doi.org/10.1007/BF01367677
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01367677