Summary
N-Boc protected non-proteinogenic dipeptides with D,L-and L,L-configuration were prepared by catalytic asymmetric hydrogenation of the corresponding dehydrophenylalanyl-(L)-phenylalanine derivatives. The configuration of the new stereogenic centre depends first of all on the catalyst configuration and is less influenced by the substrate configuration. Diastereomeric excesses in the range of 80–96% de could be increased up to 99% by recrystallization. Analytical data of selected new compounds are given.
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Abbreviations
- PINDOPHOS:
-
2,3-O,N-bis(diphenylphosphino)-1-(4-indolyloxy)-2-hydroxy-3-isopropylamino propane
- PROPRAPHOS:
-
2,3-O,N-bis(diphenylphosphino)-1-(naphthoxy)-2-hydroxy-3-isopropylamino propane
- BDPB:
-
1,4-bis(diphenylphosphino)butane
References
Döbler Ch, Kreuzfeld HJ, Fischer Ch, Michalik M (1999) Asymmetric hydrogenation of dehydrodipeptide esters bearing different protective groups. Amino Acids 16: 391–401
Hruby VJ, Al-Obeidi F, Kazmierski W (1990) Emerging approaches in the molecular design of receptor-selective peptide ligands: conformational, topographical and dynamic considerations. Biochem J 268: 249–262
Krause HW, Wilcke FW, Kreuzfeld HJ, Döbler Ch (1992) Unusual amino acids I. Asymmetric synthesis of furylalanine derivatives. Chirality 4: 110–115
Krause HW, Kreuzfeld HJ, Schmidt U, Döbler Ch, Michalik M, Taudin S, Fischer Ch (1996) Unusual amino acids VI. Substituted arylamino acids by asymmetric hydrogenation of N-Cbz and N-Boc protected dehydroamino acid derivatives. Chirality 8: 173–188
Kreuzfeld HJ, Döbler Ch, Krause HW, Facklam Ch (1993) Unusual amino acids V. Asymmetric hydrogenation of (Z)-N-acylaminocinnamic acid derivatives bearing different protective groups. Tetrahedron Asymmetry 4: 2047–2051
Kreuzfeld HJ, Döbler Ch, Schmidt U, Krause HW (1996a) Synthesis of non-proteinogenic (D)- or (L)-amino acids by asymmetric hydrogenation. (Review Article). Amino Acids 11: 269–282
Kreuzfeld HJ, Schmidt U, Döbler Ch, Krause HW (1996b) Enantioselective hydrogenation of dehydroamino acid derivatives using Pindophos-Rhodium as chiral catalyst. Tetrahedron Asymmetry 7: 1011–1018
Kutscher B, Bernd M, Beckers Th, Polymeropoulos EE, Engel J (1997) Chemie und Molekularbiologie bei der Suche nach neuen LHRH-Antagonisten. Angew Chem 109: 2240–2254
Morgan BA, Bower JD, Guest KP, Handa BK, Metcalf G, Smith CFC (1977) Structureactivity relationship of enkephalin analogs. In: Goodman M, Meienhofer J (eds) Peptides. Wiley, New York (Pept Proc Am Pept Symp 5th: 111–113)
Pinski J, Schally AV, Yano T, Groot K, Skralovic G, Reissmann Th, Bernd M, Deger W, Kutscher B, Engel J (1995) Evaluation of the in vitro and vivo activity of the L-, DLand D-Cit6forms of the LHRH antagonist Cetrorelix (SB-75). Int J Peptide Protein Res 45: 410–417
Reismann Th, Engel J, Kutscher B, Bernd M, Hilgard P, Peukert M, Szelenyi I, Reichert S, Gonzales-Barcena D, Nieschiak E, Comaru-Schally AV (1994) Cetrorelix (SB-75) LHRH antagonist. Drug in the Future 19: 228–237
Shi Chung-gi, Yonezawa Y, Watanabe E (1985) Convenient synthesis and reaction of various kinds ofα-dehydroglutamic acid derivatives. Tetrahedron Lett 26: 85–88
Wynants C, Coy DH, van Binst G (1988) Conformational study of super-active analogues of Somatostatin with reduced ring size by1H NMR. Tetrahedron 44: 941–973
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Kreuzfeld, H.J., Döbler, C., Fischer, C. et al. Synthesis of non proteinogenic dipeptides by asymmetric hydrogenation. Amino Acids 17, 369–376 (1999). https://doi.org/10.1007/BF01361662
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DOI: https://doi.org/10.1007/BF01361662