Advertisement

Pediatric Radiology

, Volume 26, Issue 9, pp 690–693 | Cite as

Epstein-Barr virus encephalitis and encephalomyelitis: MR findings

  • W. J. Shian
  • C. S. Chi
Article

Abstract

The purpose of this project is to investigate the clinical and brain MR characteristics of Epstein-Barr virus (EBV) encephalitis and encephalomyelitis. Clinical and 30 MR findings of 29 patients with EBV encephalitis or encephalomyelitis were retrospectively reviewed. Patients included 24 with encephalitis, 3 with encephalomyelitis, and 2 with brain-stem encephalitis. Altered consciousness, seizures, visual hallucination, and acute psychotic reaction were the common presentations. Eight patients had positive MR findings. These included T2 prolongation over gray and white matter, periventricular leukomalacia, and brain atrophy. Transient T2 prolongation over gray and white matter was found in one patient. Our results indicate that EBV encephalitis and encephalomyelitis have a wide range of both clinical and MR findings. The MR lesions may disappear in a short period, so the timing for the MR scan may be critical.

Keywords

White Matter Encephalitis Encephalomyelitis Brain Atrophy Virus Encephalitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bhatti N, Larson E, Hickey M, Seal D (1990) Encephalitis due to Epstein-Barr virus. J Infect 20: 69–72Google Scholar
  2. 2.
    Shoji H, Kusuhara T, Honda Y, et al (1992) Relapsing acute disseminated encephalomyelitis associated with chronic Epstein-Barr virus infection: MRI findings. Neuroradiology 34:340–342Google Scholar
  3. 3.
    Tolly TL, Wells RG, Sty JR (1989) MR features of fleeting CNS lesions associated with Epstein-Barr virus infection. J Comput Assist Tomogr 13: 665–668Google Scholar
  4. 4.
    Bray PF, Culp KW, McFarlin DE, Panitch HS, Torkelson RD, Schlight JP (1992) Demyelinating disease after neurologically complicated primary Epstein-Barr virus infection. Neurology 42:278–282Google Scholar
  5. 5.
    Grose C (1988) Neurological complications of infectious mononucleosis. In: Schlossberg D (ed) Infectious mononucleosis, 2nd edn. Springer, New York Berlin Heidelberg London Paris Tokyo, pp 49–68Google Scholar
  6. 6.
    Grose C (1985) The many faces of infectious mononucleosis: the spectrum of Epstein-Barr virus infection in children. Pediatr Rev 7: 35–44Google Scholar
  7. 7.
    Hendler N, Leahy W (1978) Psychiatric and neurologic sequelae of infectious mononucleosis. Am J Psychiatry 135: 842–844Google Scholar
  8. 8.
    Joncas JH, Chicoine L, Thivierge R, Bertrand M (1974) Epstein-Barr virus antibodies in the cerebrospinal fluid: a case of infectious mononucleosis with encephalitis. Am J Dis Child 127: 282–285Google Scholar
  9. 9.
    Halsted CC, Chang RS (1979) Infectious mononucleosis and encephalitis: recovery of EB virus from spinal fluid. Pediatrics 64: 257–258Google Scholar
  10. 10.
    Fleisher G, Henle W, Henle G, Lennette ET, Biggar RJ (1979) Primary infection with Epstein-Barr virus in infants in the United States: clinical and serological observations. J Infect Dis 139:553–558Google Scholar
  11. 11.
    Reik L Jr (1980) Disseminated vasculomyelinopathy: an immune complex disease. Ann Neurol 7: 291–296Google Scholar
  12. 12.
    Johnsen SD, Sidell AD, Bird CR (1989) Subtle encephalomyelitis in children: a variant of acute disseminated encephalomyelitis. J Child Neurol 4: 213–216Google Scholar
  13. 13.
    Alvord EC Jr, Jahnke U, Fisher EH, Kies MW, Driscoll BF, Compston DA (1987) The multiple causes of multiple sclerosis: the importance of age of infections in childhood. J Child Neurol 2: 313–321Google Scholar

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • W. J. Shian
    • 1
  • C. S. Chi
    • 2
  1. 1.Department of PediatricsTao-Yuan Veterans HospitalCity of Tao-Yuan, TaiwanRepublic of China
  2. 2.Department of PediatricsTaichung Veterans General HospitalTaichung, TaiwanRepublic of China

Personalised recommendations