Summary
In this study, we have asked what organizational features can be detected in the embryonic rat cerebral cortex. We have found evidence using light microscopy, and scanning and transmission electron microscopy, that soon after the first cortical neurons join the cortical plate, their apical dendrites form clusters. These clusters are characterized by the close apposition of dendritic membranes, and by intermediate-type junctions. Clustering occurs within 24 h of cortical plate formation, at a time when the cortical plate is about six cell diameters thick, and before the cortex has any afferent input or the cortical plate any synapses. Thus the clustering of apical dendrites in the cortical plate appears to be a very early organizational feature in the development of the cerebral cortex.
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References
Berry, M. &Rogers, A. W. (1965) The migration of neuroblasts in the developing cerebral cortex.Journal of Anatomy 99, 691–709.
Cooper, N. G. F. &Steindler, D. A. (1986) Monoclonal antibody to glial fibrillary acidic protein reveals a parcellation of individual barrels in the early postnatal mouse somotosensory cortex.Brain Research 380, 341–8.
Drenckhahn, D. &Franz, H. (1986) Identification of actin and alpha-actinin-, and vinculin-containing plaques at the lateral membrane of epithelial cells.Journal of Cell Biology 102, 1843–52.
Drury, R. A. B. &Wallington, E. A. (1980)Carleton's Histological Technique 5th ed. London: Oxford University Press.
Fleischhauer, K., Petsche, H. &Wittkowski, W. (1972) Vertical bundles of dendrites in the neocortex.Zeitschrift Anatomische Entwickl.-Gesch 136, 213–23.
Friauf, E., McConnell, S. K. &Shatz, C. J. (1990) Functional synaptic circuits in the subplate during fetal and early postnatal development of cat visual cortex.Journal of Neuroscience 10, 2601–13.
Fujita, S. (1986) Transitory differentiation of matrix cells and its functional role in the morphogenesis of the developing vertebrate CNS.Current Topics in Developmental Biology 20, 223–42.
Gadisseux, J. F., Evrard, P., Misson, J. P. &Caviness, V. S. (1989) Dynamic structure of the radial glial fibre system of the developing murine cerebral wall. An immunocyto-chemical analysis.Developments in Brain Research 50, 55–67.
Garrod, D. R. &Fleming, S. (1990) Early expression of desmosomal components during kidney tubule morphogenesis in human and murine embryos.Development 108, 313–21.
Gregory, W. A., Edmundson, J. C., Hatten, M. E. &Mason, C. A. (1988) Cytology and neuron-glial apposition of migrating cerebellar granule cellsin vitro.Journal of Neurosciences 8, 1728–38.
Hebel, R. &Stromberg, M. W. (1986)Anatomy and Embryology of the Laboratory Rat. Biomed Verlag, Worthsee.
Henrikson, C. K. &Vaughn, J. E. (1974) Fine structure relationships between neuntes and radial glial processes in developing mouse spinal cord.Journal of Neurocytology 3, 659–75.
Kalsbeek, A., Voorn, P., Biujs, R. M., Pool, C. W. &Uyeings, H. B. M. (1988) Development of the dopaminergic innervatin in the prefrontal cortex of the rat.Journal of Comparative Neurology 269, 58–72.
Kartenbeck, J., Schmid, E., Franke, W. W. &Geiger, B. (1982) Different modes of internalisation of proteins associated with adherens junctions and desmosomes: experimental separation of lateral contacts induces endocytosis of desmosomal plaque material.EMBO Journal 1, 725–32.
König, N., Roch, G. &Marty, R. (1975) The onset of synaptogenesis in rat temporal cortex.Anatomy and Embryology 148, 73–87.
Lund, R. D. &Mustari, M. J. (1977) Development of geniculocortical pathway in rats.Journal of Comparative Neurology 173, 289–306.
McConneel, S. K. (1988) Development and decisionmaking in the mammalian cerebral cortex.Brain Research Revues 13, 1–23.
McConnell, S. K., Ghosh, A. &Shatz, C. J. (1989) Subplate neurons pioneer the first axon pathway from the cerebral cortex.Science 245, 978–82.
Marin-Padilla, M. (1978) Dual origin of the mammalian neocortex and evolution of the cortical plate.Anatomy and Embryology 152, 109–26.
Peters, A. &Feldman, M. (1973) The cortical plate and molecular layer of the late rat fetus.Zeitschrift Anatomische Entwickl.-Gesch. 141, 3–37.
Peters, A. &Kara, D. A. (1987) The neuronal composition of area 17 of rat visual cortex. IV. The organization of pyramidal cells.Journal of Comparative Neurology 260, 573–90.
Peters, A. &Walsh, T. M. (1972) A study of the organization of apical dendrites in the somatic sensory cortex of the rat.Journal of Comparative Neurology 144, 253–86.
Raedler, E. &Raedler, A. (1978) Autoradiographic study of early neurogenesis in rat neocortex.Anatomy and Embryology 154, 267–312.
Rakic, P. (1972) Mode of cell migration to the superificial layers of fetal monkey neocortex.Journal of Comparative Neurology 145, 61–84.
Rice, F. L. &Van Der Loos, H. (1977) Development of the barrels and barrel field in the somatosensory cortex of the mouse.Journal of Comparative Neurology 171, 545–60.
Rickmann, M., Chronwall, B. M. &Wolff, J. R. (1977) On the development of non-pyramidal neurons and axons outside the cortical plate: the early marginal zone as a palliai anlage.Anatomy and Embryology 151, 285–307.
Roney, K. J., Scheibel, A. B. &Shaw, G. L. (1979) Dendritic bundles: survey of anatomical experiments and physiological theories.Brain Research Revues 1, 225–71.
Schmolke, C. (1989) The ontogeny of dendrite bundles in rabbit visual cortex.Anatomy and Embryology 180, 371–81.
Shoukimas, G. M. &Kinds, J. W. (1978) The development of the cerebral cortex in the embryonic mouse: an electron microscopic serial section analysis.Journal of Comparative Neurology 179, 795–830.
Smart, I. H. M. &McSherry, G. M. (1982) Growth patterns in the lateral wall of the mouse telencephalon. II. Histological changes during and subsequent to the period of isocortical neuron production.Journal of Anatomy 134, 415–42.
Sturrock, R. R. (1982) A scanning and transmission electron microscopy study of the embryonic telencephalon.Journal of Anatomy 134, 25–40.
Van Der Loos, H. &Woolsey, T. A. (1973) Somatosensory cortex: structrual alterations following early injury to sense organs.Science 179, 395–7.
Verney, C., Berger, B., Adrien, J., Vigny, A. &Gay, M. (1982) Development of the dopaminergic innervation of the rat cerebral cortex. A light microscopic immunocyto-chemical study using anti-tyrosine hydroxylase antibodies.Developmental Brain Research 5, 41–52.
White, E. L. (1976) Ultrastructure and synaptic contacts in barrels of mouse SI cortex.Brain Research 105, 229–51.
Wise, S. P. &Jones, E. G. (1978) Developmental studies of thalamocortical and commissural connections in the rat somatic sensory cortex.Journal of Comparative Neurology 178, 187–208.
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Hirst, E., Asante, J. & Price, J. Clustering of dendrites in the cerebral cortex begins in the embryonic cortical plate. J Neurocytol 20, 431–438 (1991). https://doi.org/10.1007/BF01355539
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DOI: https://doi.org/10.1007/BF01355539