Summary
Human and bovine respiratory syncytial viruses resemble each other closely. During annual winter outbreaks, they cause similar respiratory tract disease in infants and calves. The disease is most severe in children and calves between 1 and 3 months old, when maternal antibodies against the virus are usually present. Reinfections, which are common, are accompanied by progressively milder illnesses in children, but are symptomless in calves. Because maternal antibodies suppress serum and mucosal antibody responses of all isotypes, the development of a vaccine that is effective in young children and calves with high levels of maternal antibodies has been severely hampered. Although virus administered intranasally to young calves with maternal antibodies does not evoke antibody responses, it can prime these calves for a protective memory response upon reinfection. Protection appears to be associated with the capacity to mount a mucosal memory IgA response. There are several indications that one or more immunopathologic mechanisms contribute to the disease. An Arthus reaction (type III) may have a role in the pathogenesis, because activated complement may cause most of the pathologic lesions, including edema and emphysema in uninfected parts of the lung. Lungs from calves with severe or fatal disease have depositions of complement component C3 and a low histamine content. The most immunogenic and protective antigen of the virus is the fusion (F) glycoprotein, which evokes a strong antibody response and is a target for cytotoxic T cells. On the F protein, epitopes that induce neutralizing and non-neutralizing antibodies, both of which may enhance complement activation, were identified. Immunity to the F protein may have beneficial and harmful effects.
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Aherne W, Bird T, Court SDM, Gardner PS, McQuillin J (1970) Pathological changes in virus infections of the lower respiratory tract in children. J Clin Pathol 23: 7–18
Ahluwalia G, Embree J, McNicoll P, Law B, Hammond GW (1987) Comparison of nasopharyngeal aspirate and nasopharyngeal swab specimens for respiratory syncytial virus diagnosis by cell culture, indirect immunofluorescence assay, and enzyme-linked immunosorbent assay. J Clin Microbiol 25: 763–767
Aiuti F, d'Amelio R, Palmisano L, Valesini G, Luzi G, Giunchi G (1980) IgA deficiency and circulating immune complexes in Neapolitan children with fatal acute respiratory infections. Lancet ii: 226–229
Anderson LJ, Hierholzer JC, Tsou C, Hendry RM, Fernie BF, Stone Y, McIntosh K (1985) Antigenic characterization of respiratory syncytial virus strains with monoclonal antibodies. J Infect Dis 151: 626–633
Anderson LJ, Hierholzer JC, Stone YO, Tsou C, Fernie BF (1986) Identification of epitopes on respiratory syncytial virus proteins by competitive binding immunoassay. J Clin Microbiol 23: 475–480
Anderson LJ, Bingham P, Hierholzer JC (1988) Neutralization of respiratory syncytial virus by individual and mixtures of F and G protein monoclonal antibodies. J Virol 62: 4232–4238
Arumugham RG, Hildreth SW, Paradiso PR (1989) Interprotein disulphide bonding between F and G glycoproteins of human respiratory syncytial virus. Arch Virol 105: 65–79
Baker JC, Ames TR, Markham RJF (1986) Seroepizootiological study of bovine respiratory syncytial virus in a herd. Am J Vet Res 47: 240–245
Bangham CRM, Cannon MJ, Karzon DT, Askonas BA (1985) Cytotoxic T-cell response to respiratory syncytial virus in mice. J Virol 56: 55–59
Bangham CRM (1986) Passively acquired antibodies to respiratory syncytial virus impair the secondary cytotoxic T-cell response in the neonatal mouse. Immunology 59: 37–41
Bangham CRM, McMichael AJ (1986) Specific cytotoxic T cells recognize B cell lines persistently infected with respiratory syncytial virus. Proc Natl Acad Sci USA 83: 9183–9187
Bangham CRM, Askonas BA (1986) Murine cytotoxic T cells specific to respiratory syncytial virus recognize different antigenic subtypes of the virus. J Gen Virol 67: 623–629
Bangham CRM, Openshaw PJM, Ball LA, King AMQ, Wertz GW, Askonas BA (1986) Human and murine cytotoxic T cells specific to respiratory syncytial virus recognize the viral nucleoprotein (N), but not the major glycoprotein (G), expressed by vaccinia virus recombinants. J Immunol 137: 3973–3977
Beeler JA, van Wyke Coeling K (1989) Neutralization epitopes of the F glycoprotein of respiratory syncytial virus: effect of mutation upon fusion function. J Virol 63: 2941–2950
Bruhn FW, Yeager AS (1977) Respiratory syncytial virus in early infancy. Circulating antibody and the severity of infection. Am J Dis Child 131: 145–148
Bryson DG, McFerran JB, Ball HJ, Neill SD (1979) Observations on outbreaks of respiratory disease in calves associated with parainfluenza type 3 virus and respiratory syncytial virus infection. Vet Rec 104: 45–49
Bui RHD, Molinaro GA, Kettering JD, Heiner DC, Imagawa DT, Geme JWS (1987) Virus-specific IgE and IgG4 antibodies in serum of children infected with respiratory syncytial virus. J Pediatr 110: 87–90
Busse WW, Swenson CA, Borden EC, Treuhaft MW, Dick EC (1983) Effect of influenza A virus on leukocyte histamine release. J Allergy Clin Immunol 71: 382–388
Butler JE (1983) Bovine immunoglobulins: an augmented review. Vet Immunol Immunopathol 4: 43–152
Cannon MJ, Stott EJ, Taylor G, Askonas BA (1987) Clearance of persistent respiratory syncytial virus infections in immunodeficient mice following transfer of primed T cells. Immunology 62: 133–138
Cannon MJ, Openshaw PJ, Askonas BA (1988) Cytotoxic T cells clear virus but augment lung pathology in mice infected with respiratory syncytial virus. J Exp Med 168: 1163–1168
Cannon MJ, Bangham CRM (1989) Recognition of respiratory syncytial virus fusion protein by mouse cytotoxic T cell clones and a human cytotoxic T cell line. J Gen Virol 70: 79–87
Cash P, Wunner WH, Pringle CR (1977) A comparison of the polypeptides of human and bovine respiratory syncytial viruses and murine pneumonia virus. Virology 82: 369–397
Chanock RM, Kapikian AZ, Mills J, Kim HW, Parrott RH (1970) Influence of immunological factors in respiratory syncytial virus disease. Arch Environ Health 21: 347–356
Chiba Y, Minagawa T, Mito K, Nakane A, Suga K, Honjo T, Nakao T (1987) Effect of breast feeding on responses of interferon and virus-specific lymphocyte transformation in infants with respiratory syncytial virus infection. J Med Virol 21: 7–14
Chonmaitree T, Bessette-Henderson BJ, Hepler RE, Lucia HL (1987) Comparison of three rapid diagnostic techniques for detection of respiratory syncytial virus from nasal wash specimens. J Clin Microbiol 325: 740–747
Coates HV, Chanock RM (1962) Experimental infection with respiratory syncytial virus in several species of animals. Am J Hyg 76: 302–312
Collins PL, Wertz GW (1986) Human respiratory syncytial virus genome and gene products. In: Notkins AL, Oldstone MBA (eds) Concepts in viral pathogenesis, vol 2. Springer, Berlin Heidelberg New York Tokyo, pp 40–46
Collins PL, Dickens LE, Buckler-White A, Olmsted RA, Spriggs MK, Camargo E, Coelingh KVW (1986) Nucleotide sequences for the gene junctions of human respiratory syncytial virus reveal distinctive features of intergenic structure and gene order. Proc Natl Acad Sci USA 83: 4594–4598
De Leeuw PW, Kamp EM, Kimman TG, Ter Laak EA, Straver PJ, Zimmer GM (1984) Luchtwegaandoeningen bij kalveren. In: Annual report. Central Veterinary Institute, Lelystad, The Netherlands, pp 13–18
Dickens LE, Collins PL, Wertz GW (1984) Transcriptional mapping of human respiratory syncytial virus. J Virol 52: 364–369
Domurat F, Roberts NJ, Walsh EE, Dagan R (1985) Respiratory syncytial virus infection of human mononuclear leukocytes in vitro and in vivo. J Infect Dis 152: 895–902
Downham MAPS, Scott R, Sims DG, Webb JKG, Gardner PS (1976) Breast-feeding protects against respiratory syncytial virus infections. Br Med J 2: 274–276
Edwards S, Newman RH, Stanley M (1984) Respiratory syncytial virus diagnosis. Vet Rec 114: 101
Elango N, Prince GA, Murphy BR, Venkatesan S, Chanock RM, Moss BA (1986) Resistance to human respiratory syncytial virus (RSV) infection induced by immunization of cotton rats with a recombinant vaccinia virus expressing the RSV G glycoprotein. Proc Natl Acad Sci USA 83: 1906–1910
Faden H, Hong JJ, Ogra PL (1984) Interaction of polymorphonuclear leukocytes and viruses in humans: adherence of polymorphonuclear leukocytes to respiratory syncytial virus-infected cells. J Virol 52: 16–23
Fishaut M, Tubergen D, McIntosh K (1980) Cellular response to respiratory viruses with particular reference to children with disorders of cell-mediated immunity. J Pediatr 96: 179–186
Freymuth F, Quibriac M, Petitjean J, Amiel ML, Pothier P, Denis A, Duhamel JF (1986) Comparison of two new tests for rapid diagnosis of respiratory syncytial virus infections by enzyme-linked immunosorbent assay and immunofluorescent techniques. J Clin Microbiol 24: 1013–1016
Gimenez HB, Hardman N, Keir HM, Cash P (1986) Antigenic variation between human respiratory syncytial virus isolates. J Gen Virol 67: 863–870
Gimenez HB, Keir HM, Cash P (1987) Immunoblot analysis of the human antibody response to respiratory syncytial virus infection. J Gen Virol 68: 1267–1275
Gimenez HB, Keir HM, Cash P (1989) In vitro enhancement of respiratory syncytial virus infection of U937 cells by human sera. J Gen Virol 70: 89–96
Glezen WP, Denny FW (1973) Epidemiology of acute lower respiratory disease in children. New Eng J Med 288: 498–505
Glezen WP (1977) Pathogenesis of bronchiolitis-epidemiologic considerations. Pediatr Res 11: 239–243
Glezen WP, Paredes A, Allison JE, Taber LH, Frank AL (1981) Risk of respiratory syncytial virus infection for infants from low income families in relationship to age, sex, ethnic group, and maternal antibody level. J Pediatr 98: 708–715
Hall CB, Kopelman AE, Douglas RG, Geiman JM, Meagher MP (1979) Neonatal respiratory syncytial virus infection. N Engl J Med 300: 393–396
Hall CB, Douglas RG (1981) Modes of transmission of respiratory syncytial virus. J Pediatr 99: 100–103
Harte PG, Playfair JHL (1983) Failure of malaria vaccination in mice born to immune mothers. II. Induction of specific suppressor cells by maternal IgG. Clin Exp Immunol 51: 157–164
Henderson FW, Collier AM, Clyde WA, Denny FEW (1979). Respiratory syncytial virus infections, reinfections and immunity. N Engl J Med 300: 530–534
Hendry RM, Pierik LT, McIntosh K (1989) Prevalence of respiratory syncytial virus subgroups over six consecutive outbreaks: 1981–1987. J Infect Dis 160: 185–190
Holzhauer C (1978) Pinkengriep. Doctoral Thesis, University of Utrecht, Utrecht, The Netherlands
Hornsleth A, Bech-Thomsen N, Friis B (1985) Detection of RS-virus IgG-subclass-specific antibodies: variation according to age in infants and small children and diagnostic value in RS-virus-infected small infants. J Med Virol 16: 329–335
Hugli TE (1985) Structure and function of the anaphylatoxins. In: Müller-Eberhard HJ, Miescher PA (eds) Complement. Springer, Berlin Heidelberg New York Tokyo, pp 73–100
Hunninghake GW, Gadek JE, Kawanami O, Ferrans VJ, Crystal RG (1979) Inflammatory and immune processes in the human lung in health and disease: evaluation by bronchoalveolar lavage. Am J Pathol 97: 149–206
Ida S, Hooks JJ, Siraganian RP, Notkins AL (1977) Enhancement of IgE-mediated histamine release from human basophils by viruses: role of interferon. J Exp Med 145: 892–906
Inaba Y, Tanaka Y, Omori T, Matumoto M (1970) Isolation of bovine respiratory syncytial virus. Jpn J Exp Med 40: 473
Jacobs JW, Edington N (1975) Experimental infection of calves with respiratory syncytial virus. Res Vet Sci 18: 299–306
Kasel JA, Walsh EE, Frank AL, Baxter BD, Taber LH, Glezen WP (1987/1988) Relation of serum antibody to glycoproteins of respiratory syncytial virus with immunity to infection in children. Viral Immunol 1: 199–205
Kaul TN, Welliver RC, Ogra PL (1982) Appearance of complement components and immunoglobulins on nasopharyngeal epithelial cells following naturally acquired infection with respiratory syncytial virus. J Med Virol 9: 149–158
Kaul TN, Faden H, Baker R, Ogra PL (1984) Virus-induced complement activation and neutrophil-mediated cytotoxicity against respiratory syncytial virus (RSV). Clin Exp Immunol 56: 501–508
Kennedy HE, Jones BV, Tucker EM, Ford NJ, Clarke SW, Furze J, Thomas LH, Stott EJ (1988) Production and characterization of bovine monoclonal antibodies to respiratory syncytial virus. J Gen Virol 69: 3023–3032
Key DW, Derbyshire JB (1984) Serological studies of parainfluenza type 3 virus, bovine adenovirus type 3 and bovine respiratory syncytial virus infection in beef calves. Vet Microbiol 9: 587–592
Kim HW, Leifkin SL, Arrobio J, Brandt CD, Chanock RM, Parrott RH (1976) Cellmediated immunity to respiratory syncytial virus induced by inactivated vaccine or by infection. Pediatr Res 10: 75–78
Kimman TG, Zimmer GM, Straver PJ, de Leeuw P (1986) Diagnosis of bovine respiratory syncytial virus infections improved by virus detection in lung lavage samples. Am J Vet Res 47: 143–147
Kimman TG, Westenbrink F, Straver PJ, van Zaane D, Schreuder BEC (1987) Isotype-specific ELISAs for the detection of antibodies to bovine respiratory syncytial virus. Res Vet Sci 43: 180–187
Kimman TG, Westenbrink F, Schreuder BEC, Straver PJ (1987) Local and systemic antibody response to bovine respiratory syncytial virus infection and reinfection in calves with and without maternal antibodies. J Clin Microbiol 25: 1097–1106
Kimman TG, Zimmer GM, Westenbrink F, Mars J, van Leeuwen E (1988) Epidemiological study of bovine respiratory syncytial virus infections in calves: influence of maternal antibodies on the outcome of disease. Vet Rec 124: 104–109
Kimman TG, Straver PJ, Zimmer GM (1989) Pathogenesis of naturally acquired bovine respiratory syncytial virus infection in calves: morphologic and serologic findings. Am J Vet Res 50: 684–693
Kimman TG, Terpstra GK, Daha MR, Westenbrink F (1989) Pathogenesis of naturally acquired bovine respiratory syncytial virus infection in calves: evidence for the involvement of complement and mast cell mediators. Am J Vet Res 50: 694–700
Kimman TG, Daha MR, Brinkhof JMA, Westenbrink F (1989) Activation of complement by bovine respiratory syncytial virus-infected cells. Vet Immunol Immunopathol 21: 311–325
Kimman TG, Westenbrink F, Straver PJ (1989) Priming for local and systemic antibody memory responses to bovine respiratory syncytial virus: effect of amount of virus, virus replication, route of administration and maternal antibodies. Vet Immunol Immunopathol 22: 145–160
Kimman TG, Sol J, Westenbrink F, Straver PJ (1989) A severe outbreak of respiratory tract disease associated with bovine respiratory syncytial virus probably enhanced by vaccination with modified live vaccine. Vet Q 11: 250–253
King AMQ, Stott EJ, Langer SJ, Young KK-Y, Ball LA, Wertz GW (1987) Recombinant vaccinia viruses carrying the N gene of human respiratory syncytial virus: studies of gene expression in cell culture and immune response in mice. J Virol 61: 2885–2890
Kingsburry DW, Bratt MA, Choppin PW, Hanson RP, Hosaka Y, Ter Meulen V, Norrby E, Plowright W, Rott R, Wunner WH (1978) Paramyxoviridae. Intervirology 10: 137–152
Krilov LR, Anderson LJ, Marcoux L, Bonagura VR, Wedgewood F (1989) Antibody-mediated enhancement of respiratory syncytial virus infection in two monocyte/macrophage cell lines. J Infect Dis 160: 777–782
Kumagai T, Wong DT, Ogra PL (1985) Development of cell-mediated cytotoxic activity in the respiratory tract after experimental infection with respiratory syncytial virus. Clin Exp Immunol 61: 351–359
Lamprecht CL, Krause HE, Mufson MA (1976) Role of maternal antibody in pneumonia and bronchiolitis due to respiratory syncytial virus. J Infect Dis 134: 211–217
Lerch RA, Stott EJ, Wertz GW (1989) Characterization of bovine respiratory syncytial virus proteins and mRNAs and generation of cDNAs clones to the viral mRNAs. J Virol 63: 833–840
Levine S, Klaiber-Franco R, Paradiso PR (1987) Demonstration that glycoprotein G is the attachment protein of respiratory syncytial virus. J Gen Virol 69: 119–1239
Levine S, Dajani A, Klaiber-Franco R (1988) The response of infants with bronchiolitis to the proteins of respiratory syncytial virus. J Gen Virol 69: 1229–1239
Martin H (1967) Some considerations in dealing with respiratory disease in calves. Vet Rec 81: 255–261
Matumoto M, Inaba Y, Kutogi H, Sato K, Omori T, Goto Y, Hirose O (1974) Bovine respiratory syncytial virus: host range in laboratory animals and cell cultures. Arch Ges Virusforsch 44: 280–290
Mazanec MB, Nedrud JG, Lamm ME (1987) Immunoglobulin A monoclonal antibodies protect against Sendai virus. J Virol 61: 2624–2626
McIntosh K, Masters HB, Orr I, Chao RK, Barkin RM (1978) The immunological response to infection with respiratory syncytial virus in infants. J Infect Dis 138: 24–32
McIntosh K, McQuillin, Gardner PS (1979) Cell-free and cell-bound antibody in nasal secretions from infants with respiratory syncytial virus infection. Infect Immun 23: 276–281
McIntosh K, Fishaut JM (1980) Immunopathologic mechanisms in lower respiratory tract disease of infants due to respiratory syncytial virus. Prog Med Virol 26: 94–118
McNulty MS, Bryson DG, Allan M (1983) Experimental respiratory syncytial virus pneumonia in young calves: microbiologic and immunofluorescent findings. Am J Vet Res 44: 1656–1659
Meurman O, Ruuskanen O, Sarkkinnen H, Hanninen P, Halonen P (1984) Immunoglobulin class-specific antibody response in respiratory syncytial virus infection measured by enzyme immunoassay. J Med Virol 14: 67–72
Mills J, van Kirk JE, Wright PF, Chanock RM (1971) Experimental respiratory syncytial virus infection of adults. Possible mechanisms of resistance to infection and illness. J Immunol 107: 123–130
Mohanty SB, Lillie MG, Ingling AL (1976) Effect of serum and nasal neutralizing antibodies on respiratory syncytial virus infection in calves. J Infect Dis 134: 409–413
Morales F, Calder MA, Inglis JM, Murdoch PS, Williamson J (1983) A study of respiratory infections in the elderly to assess the role of respiratory syncytial virus. J Infect 7: 236–247
Morrison TG (1988) Structure, function and intracellular processing of paramyxovirus membrane proteins. Virus Res 10: 113–136
Mufson MA, Orvell C, Rafnar B, Norrby E (1985) Two distinct subtypes of human respiratory syncytial virus. J Gen Virol 66: 2111–2124
Mufson MA, Belshe RB, Orvell C, Norrby E (1987) Subgroup characteristics of respiratory syncytial virus strains recovered from children with two consecutive infections. J Clin Microbiol 25: 1535–1539
Mufson MA, Belshe RB, Orvell C, Norrby E (1988) Respiratory syncytial virus epidemics: variable dominance of subgroups A and B strains among children, 1981–1986. J Infect Dis 157: 143–148
Murphy BR, Prince GA, Walsh EE, Kim HW, Parrott RH, Hemming VG, Rodriguez WJ, Chanock RM (1986) Dissociation between serum neutralizing and glycoprotein antibody responses of infants and children who received inactivated respiratory syncytial virus vaccine. J Clin Microbiol 24: 197–202
Murphy BR, Graham BS, Prince GA, Walsh EE, Chanock RM, Karzon DT, Wright PF (1986) Serum and nasal-wash immunoglobulin G and A antibody response of infants and children to respiratory syncytial virus F and G glycoproteins following primary infection. J Clin Microbiol 23: 1009–1014
Murphy BR, Alling DW, Snyder MH, Walsh EE, Prince GA, Chanock RM, Hemming VG, Rodriguez WJ, Kim HW, Graham BS, Wright PF (1986) Effect of age and preexisting antibody on serum antibody response of infants and children to the F and G glycoproteins during respiratory syncytial virus infection. J Clin Microbiol 24: 894–898
Murphy BR, Olmsted RA, Collins PL, Chanock RM, Prince GA (1988) Passive transfer of respiratory syncytial (RSV) antiserum suppresses the immune response to the RSV fusion (F) and large (G) glycoproteins expressed by recombinant vaccinia viruses. J Virol 62: 3907–3910
Murphy BR, Walsh EE (1988) Formalin-inactivated respiratory syncytial virus vaccine induces antibodies to the fusion glycoprotein that are deficient in fusion-inhibiting activity. J Clin Microbiol 26: 1595–1597
Nandapalan N, Taylor C, Scott R, Toms GL (1987) Mammary immunity in mothers of infants with respiratory syncytial virus infection. J Med Virol 22: 277–287
Nicholas JA, Mitchell MA, Levely ME, Rubino KL, Kinner JH, Harn NK, Smith CW (1988) Mapping an antibody-binding site and a T-cell-stimulating site on the 1A protein of respiratory syncytial virus. J Virol 62: 4465–4473
Nicholas JA, Levely MA, Mitchell MA, Smith CW (1989) A 16-amino acid peptide of respiratory syncytial virus 1A protein contains two overlapping T cell-stimulating sites distinguishable by class II MHC restriction elements. J Immunol 143: 2790–2796
Ogilvie MM, Vathenen AS, Radford M, Codd J, Key S (1981) Maternal antibody and respiratory syncytial virus infection in infancy. J Med Virol 7: 263–271
Olmsted RA, Elango N, Prince GA, Murphy BR, Johnson PR, Moss B, Chanock RM, Collins PL (1986) Expression of the F glycoprotein of respiratory syncytial virus by a recombinant vaccinia virus: comparison of the individual contributions of the F and G glycoproteins to host immunity. Proc Natl Acad Sci USA 83: 7462–7466
Olmsted RA, Collins PL (1989) The 1A protein of respiratory syncytial virus is an integral membrane protein present as multiple, structurally distinct species. J Virol 63: 2019–2029
Openshaw PJM, Pemberton RM, Ball LA, Wertz GW, Askonas BA (1988) Helper T cell recognition of respiratory syncytial virus in mice. J Gen Virol 69: 305–312
Orvell C, Norrby E, Mufson MA (1987) Preparation and characterization of monoclonal antibodies directed against five structural components of human respiratory syncytial virus subgroups B. J Gen Virol 68: 3125–3135
Paccaud MF, Jacquier C (1970) A respiratory syncytial virus of bovine origin. Arch Ges Virusforsch 30: 327–342
Parrot RH, Kim HW, Arrobio JO, Hodes DS, Murphy BR, Brandt CD, Camargo E, Chanock RM (1973) Epidemiology of respiratory syncytial virus infection in Washington, D.C. II. Infection and disease with respect to age, immunologic status, race and sex. Am J Epidemiol 98: 289–300
Pemberton RM, Cannon MJ, Openshaw PJM, Ball LA, Wertz GW, Askonas BA (1987) Cytotoxic T cell specificity for respiratory syncytial virus proteins: fusion protein is an important target antigen. J Gen Virol 68: 2177–2182
Pirier HM, Petrie L, Pringle CR, Allan EM, Kennedy GJ (1981) Acute fatal pneumonia in calves due to respiratory syncytial virus. Vet Rec 108: 411–416
Prince GA, Jenson AB, Horswood RL (1978) The pathogenesis of respiratory syncytial virus infection in cotton rats. Am J Pathol 93: 771–792
Prince GA, Potash L, Horswood RL, Camargo E, Suffin SC, Johnson RA, Chanock RM (1979) Intramuscular inoculation of live respiratory syncytial virus induces immunity in cotton rats. Infect Immun 23: 723–728
Prince GA, Horswood RL, Koenig DW, Chanock RM (1985) Antigenic analysis of a putative new strain of respiratory syncytial virus. J Infect Dis 151: 634–637
Prince GA, Horswood RL, Chanock RM (1985) Quantitative aspects of immunity to respiratory syncytial virus infection in infant cotton rats. J Virol 55: 517–520
Prince GA, Jenson AB, Hemming VG, Murphy BR, Walsh EE, Horswood RL, Chanock RM (1986) Enhancement of respiratory syncytial virus pulmonary pathology in cotton rats by prior intramuscular inoculation of formalin-inactivated virus. J Virol 57: 721–728
Prince GA, Hemming VG, Horswood RL, Baron PA, Chanock RM (1987) Effectiveness of topically administered neutralizing antibodies in experimental immunotherapy of respiratory syncytial virus infection in cotton rats. J Virol 61: 1851–1854
Pringle CR (1987) Progress towards control of the acute respiratory viral diseases of childhood. Bull WHO 63: 133–137
Pullan CR, Toms GL, Martin AJ, Gardner PS, Webb JKG, Appleton DR (1980) Breast-feeding and respiratory syncytial virus infection. Br Med J 281: 1034–1036
Reiter J, Hutchings P, Lydyard PM, Cooke A (1986) Antibody-mediated modulation of the immune response. Cell Immunol 97: 91–101
Report to the Medical Research Council Subcommittee on respiratory syncytial virus vaccines (1978) Br Med J 2: 796–798
Richardson LS, Yolken RH, Belshie RB, Camargo E, Kim HW, Chanock RM (1978) Enzyme-linked immunosorbent assay for measurement of serological response to respiratory syncytial virus infection. Infect Immun 20: 660–664
Richman AV, Pedreira FA, Tauraso NM (1971) Attempts to demonstrate hemagglutination and hemadsorption by respiratory syncytial virus. Appl Microbiol 21: 1099
Routledge EG, Willcocks MM, Morgan L, Samson ACR, Scott R, Toms GL (1987) Expression of the respiratory syncytial virus 22 k protein on the surface of infected HeLa cells. J Gen Virol 68: 1217–1222
Routledge EG, Willcocks MM, Samson ACR, Morgan L, Scott R, Anderson JJ, Toms GL (1988) The purification of four respiratory syncytial virus proteins and their evaluation as protective agents against experimental infection in BALB/c mice. J Gen Virol 69: 293–303
Samson ACR, Willcocks MM, Routledge EG, Morgan LA, Toms GL (1986) A neutralizing monoclonal antibody to respiratory syncytial virus which binds to both F1 and F2 components of the fusion protein. J Gen Virol 67: 1479–1483
Scott R, DeLandazuri MO, Gardner PS, Own JJT (1976) Detection of antibody to respiratory syncytial virus by membrane fluorescence. Clin Exp Immunol 26: 78–85
Scott R, Kaul A, Scott M, Chiba Y, Ogra PL (1978) Development of in vitro correlates of cell-mediated immunity to respiratory syncytial virus infection in humans. J Infect Dis 137: 810–817
Scott R, Scott M, Toms GL (1981) Cellular and antibody response to respiratory syncytial (RS) virus in human colostrum, maternal blood, and cord blood. J Med Virol 8: 55–66
Stewart RS, Gershwin LJ (1989) Role of IgE in the pathogenesis of bovine respiratory syncytial virus in sequential infections in vaccinated and nonvaccinated calves. Am J Vet Res 50: 349–355
Stott EJ, Thomas LH, Collins AP, Crough S, Jebbett J, Smith GS, Luther PD, Caswell R (1980) A survey of virus infections of the respiratory tract of cattle and their association with disease. J Hyg 85: 257–270
Stott EJ, Thomas LH, Taylor G, Collins AP, Jebbett J, Crough S (1984) A comparison of three vaccines against respiratory syncytial virus in calves. J Hyg 93: 251–261
Stott EJ, Taylor G (1985) Respiratory syncytial virus. Brief Review. Arch Virol 84: 1–52
Stott EJ, Ball LA, Young KK-Y, Furze J, Wertz GW (1986) Human respiratory syncytial virus glycoprotein expressed from a recombinant vaccinia virus vector protects mice against live virus challenge. J Virol 60: 607–613
Stott EJ, Taylor G, Ball LA, Anderson K, Young KK-Y, King AMQ, Wertz GW (1987) Immune and histopathological responses in animals vaccinated with recombinant vaccinia viruses that express individuals genes of human respiratory syncytial virus. J Virol 61: 3855–3861
Stott EJ, Taylor G (1989) Immunity to respiratory syncytial virus. In: Dimmock NJ, Minor PD (eds) Immune responses, virus infections and disease. Oxford University Press, Oxford, pp 85–104
Taylor B, Wadsworth J, Golding J, Butler N (1982) Breast-feeding, bronchiolitis, and admissions for lower-respiratory illness and gastroenteritis during the first five years. Lancet i: 1227–1229
Taylor G, Stott EJ, Hughes M, Collins AP (1984) Respiratory syncytial virus infection in mice. Infect Immun 43: 649–655
Taylor G, Stott EJ, Bew M, Ferni BF, Cote PJ, Collins AP, Hughes M, Jebbet J (1984) Monoclonal antibodies protect against respiratory syncytial virus infection in mice. Immunology 52: 137–142
Taylor G, Stott EJ, Hayle AJ (1985) Cytotoxic lymphocytes in the lungs of mice infected with respiratory syncytial virus. J Gen Virol 66: 2533–2538
Taylor G, Stott EJ, Thomas LH (1987) Lymphocyte transformation responses of calves to respiratory syncytial virus. J Med Virol 22: 333–334
Thatcher EF, Gershwin LJ (1988) Generation and characterization of murine monoclonal antibodies specific for bovine immunoglobulin E. Vet Immunol Immunopathol 18: 53–66
Thomas LH, Stott EJ (1981) Diagnosis of respiratory syncytial virus infection in the bovine respiratory tract by immunofluorescence. Vet Rec 108: 432–435
Toms GL, Scott R (1987) Respiratory syncytial virus and the infant immune response. Arch Dis Childhood 62: 544–546
Treuhaft MW, Soukop JM, Sullivan BJ (1985) Practical recommendation for the detection of pediatric respiratory syncytial virus infection in infants. Pediatrics 72: 613–618
Trigo E, Liggitt HD, Evermann JF, Breeze RG, Huston LY, Silflow R (1985) Effect of in vitro inoculation of bovine respiratory syncytial virus on bovine pulmonary alveolar macrophage function. Am J Vet Res 46: 1098–1103
Trudel M, Nadon F, Seguin C, Ghobril S, Payment P, Trepanier P (1986) Immunovirological studies on human respiratory syncytial virus structural proteins. Can J Microbiol 32: 15–21
Trudel M, Nadon F, Seguin C, Dionne G, Lacroix M (1987) Identification of a synthetic peptide as part of a major neutralization epitope of respiratory syncytial virus. J Gen Virol 68: 2273–2280
Trudel M, Nadon F, Simard C, Belanger F, Alain R, Seguin C, Lussier G (1989) Comparison of caprine, human and bovine strains of respiratory syncytial virus. Arch Virol 107: 141–149
Trudel M, Nadon F, Seguin C, Simard C, Lussier G (1989) Experimental polyvalent ISCOMs subunit vaccine induces antibodies that neutralize human and bovine respiratory syncytial virus. Vaccine 7: 12–16
Tsutsumi H, Flanagan TD, Ogra PL (1987) Monoclonal antibodies to the large glycoprotein of respiratory syncytial virus: Possible evidence for several functional antigenic sites. J Gen Virol 68: 2161–2167
Tsutsumi H, Onuma M, Suga K, Honjo T, Chiba Y, Chiba S, Ogra PL (1988) Occurrence of respiratory syncytial virus subgroups A and B strains in Japan, 1980 to 1987. J Clin Microbiol 26: 1171–1174
Vainionpää R, Meurman O, Sarkinnen H (1985) Antibody response to respiratory syncytial virus structural proteins in children with acute respiratory syncytial virus infection. J Virol 53: 976–979
Verhoeff J, Van Nieuwstadt APKMI (1984) BRS virus, PI3 virus and BHV1 infections of young stock on self-contained dairy farms: epidemiological and clinical findings. Vet Rec 114: 288–293
Vikerfors T, Grandien M, Olcen P (1987) Respiratory syncytial virus infections in adults. Am Rev Respir Dis 136: 561–564
Volovitz B, Welliver RC, Castro GD, Krystofik DA, Ogra PL (1988) The release of leukotrienes in the respiratory tract during infection with respiratory syncytial virus: role in obstructive airway disease. Pediatr Res 24: 504–507
Wagner DK, Graham BS, Wright PF, Walsh EE, Kim HW, Reimer CB, Nelson DL, Chanock RM, Murphy BR (1986) Serum immunoglobulin G antibody subclass responses to respiratory syncytial virus F and G glycoproteins after primary infection. J Clin Microbiol 24: 304–306
Wagner DK, Muelenaer P, Henderson FW, Snyder MH, Reimer CB, Walsh EE, Anderson LJ, Nelson DL, Murphy BR (1989) Serum immunoglobulin G antibody subclass response to respiratory syncytial virus F and G glycoproteins after first, second, and third infections. J Clin Microbiol 27: 589–592
Walsh EE, Hruska J (1983) Monoclonal antibodies to respiratory syncytial virus proteins: identification of the fusion protein. J Virol 47: 171–177
Walsh EE, Schlesinger JJ, Brandriss MW (1984) Protection from respiratory syncytial virus infection in cotton rats by passive transfer of monoclonal antibodies. Infect Immun 43: 756–758
Walsh EE, Cote PJ, Fernie BF, Schlesinger JJ, Brandriss MW (1986) Analysis of the respiratory syncytial virus fusion protein using monoclonal and polyclonal antibodies. J Gen Virol 67: 505–513
Walsh EE, Hall CB, Briselli M, Brandriss MW, Schlesinger JJ (1987) Immunization with glycoprotein subunits of respiratory syncytial virus to protect cotton rats against viral infection. J Infect Dis 155: 1198–1204
Walsh EE, Hall CB, Schlesinger JJ, Brandriss MW, Hildreth S, Paradiso P (1989) Comparison of antigenic sites of subtype-specific respiratory syncytial virus attachment protein. J Gen Virol 70: 2953–2961
Wang M-L, Skehal JJ, Wiley DC (1986) Comparative analyses of the specificities of anti-influenza hemagglutinin antibodies in human sera. J Virol 57: 124–128
Ward KA, Lambden PR, Ogilvie MM, Watt PJ (1983) Antibodies to respiratory syncytial virus polypeptides and their significance in human infection. J Gen Virol 64: 1867–1876
Wellemans G (1977) Laboratory diagnosis methods for bovine respiratory syncytial virus. Vet Sci Commun 1: 179–198
Welliver RC, Kaul TN, Ogra PL (1979) Cell-mediated immune response to respiratory syncytial virus infection: relationship to the development of reactive airway disease. J Pediatr 94: 370–375
Welliver RC, Kaul TN, Putnam TI, Sun M, Riddlesberger K, Ogra PL (1980) The antibody response to primary and secondary infection with respiratory syncytial virus: kinetics of class-specific responses. J Pediatr 96: 808–813
Welliver RC, Kaul TN, Sun M, Ogra PL (1984) Defective regulation of immune responses in respiratory syncytial virus infection. J Immunol 133: 1925–1930
Welliver RC (1988) Detection, pathogenesis, and therapy of respiratory syncytial virus infections. Clin Microbiol Rev 1: 27–39
Welliver RC, Sun M, Hildreth SW, Arumugham R, Ogra PL (1989) Respiratory syncytial virus-specific antibody responses in immunoglobulin A and E isotypes to the F and G proteins and to intact virus after natural infection. J Clin Microbiol 27: 295–299
Wertz GW, Stott EJ, Young KK-Y, Anderson K, Ball LA (1987) Expression of the fusion protein of human respiratory syncytial virus from recombinant vaccinia virus vectors and protection of vaccinated mice. J Virol 61: 293–301
Westenbrink F, Kimman TG (1987) Immunoglobulin M-specific enzyme-linked immunosorbent assay for serodiagnosis of bovine respiratory syncytial virus infections. Am J Vet Res 48: 1132–1137
Westenbrink F, Kimman TG, Brinkhof JMA (1989) Analysis of the antibody response to bovine respiratory syncytial virus proteins in calves. J Gen Virol 70: 591–601
Wong DT, Ogra PL (1986) Neonatal respiratory syncytial virus infection: role of transplacentally and breast milk-acquired antibodies. J Virol 57: 1203–1206
Zygraich N, Wellemans G (1981) Immunologic markers of an attenuated bovine respiratory syncytial (BRS) vaccine. Zentralbl Veterinaermed [B] 28: 355–362
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Kimman, T.G., Westenbrink, F. Immunity to human and bovine respiratory syncytial virus. Archives of Virology 112, 1–25 (1990). https://doi.org/10.1007/BF01348982
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DOI: https://doi.org/10.1007/BF01348982