Summary
Alveolar macrophages isolated by pulmonary lavage from partially taurine-depleted ratsdemonstrated increased (2–2.6 fold) chemiluminescence due to the extracellular reaction between exogenous zymosan and various reactive forms of oxygen compared to macrophages isolated from control animals. Partial taurine depletion was achieved by adding 3% ß-alanine to the drinking water of the rats for 5 weeks prior to harvesting the macrophages. Superoxide dismutase activity was not increased in the lung tissue of the taurine-depleted rats. These data suggest that taurine has antioxidant properties and that taurine depletion is potentially deleterious to alveolar macrophages and pulmonary tissue.
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Zhang, X., Lombardini, J.B. Effects ofin vivo taurine depletion on induced- chemiluminescence production in macrophages isolated from rat lungs. Amino Acids 15, 179–186 (1998). https://doi.org/10.1007/BF01345290
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DOI: https://doi.org/10.1007/BF01345290