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Effect of methyl thiouracil on radioiodine thyroidal retention in rats

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Summary

Some goitrogens like methyl thiouracil (MTU) because of their thynamide grouping act as antithyroid drugs inhibiting the organification of iodide, but do not alter the iodide transport. Their administration to an intact animal, therefore, might alter the thyroidal iodine kinetics. Here an attempt has been made to study the effect of MTU on thyroidal iodine kinetics in rats as well as to find out whether any difference in kinetics could be detected between different radioiodines, viz.,131I,125I, and123I. Cumulated thyroidal activity which is a time integral of the activity has been taken as the parameter to represent the sum effect of thyroidal iodine kinetics over a specific time period of interest.

From the in vivo thyroidal activity measurements, carried out over extended periods of time, the cumulated activity was calculated for both MTU treated and normal rats that received131I,125I, or123I at different times before the MTU start. Within a day of the start of the MTU there is a rapid loss of thyroidal iodine. The severity of the loss depended upon the time that elapsed between the start of the MTU schedule and the particular radioiodine administered. The absence of isotopic effect on the uptake as well as on the rate of uptake for the three different radioiodine isotopes studied has been brought out.

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References

  • Green, W. L.: Mechanisms of action of antithyroid compounds. In: Werner, S. C., Ingbar, S. H. (eds.). The thyroid, p. 41–51. New York: Harper & Row, Publishers 1971

    Google Scholar 

  • Greig, W. R., Smith, J. F. B., Duguid, W. P., Foster, C. J., Orr, J. S.: Assessment of rat thyroid as a radiobiological model: The effects of X-irradiation on cell proliferation and DNA synthesis in vivo. Int. J. Radiat. Biol.16, 211 (1969)

    Google Scholar 

  • Lewitus, Z., Lubin, E., Rechnic, J., Rosenberg, T., Laor, J., Ben-Porath, M., Feige, Y.: Two years experience in the use of125I for the treatment of thyrotoxicosis. In: Proceedings of IV International Conference on Peaceful Uses of Atomic Energy, vol. 13, p. 337. Vienna: International Atomic Energy Agency 1972

    Google Scholar 

  • Loevinger, R., Berman, M.: A revised schema for calculating the absorbed dose from biologically distributed radionuclides. nm/mird pamphlet No. 1, revised. New York: Society of Nuclear Medicine 1976

    Google Scholar 

  • Lotter, M. G., Van der Merwe, E. J., Van Heerden, P. D. R., Le Roux, P. L. M.: The use of123I in thyroid diagnosis. S.Afr. Med. J.46, 186 (1972)

    Google Scholar 

  • Mazumdar, S. K.: Thyroid function, pathophysiology, nuclear therapeutics in thyroid diseases. Final report AFMRC No. 552/74. Delhi: Institute of Nuclear Medicine & Allied Sciences 1976

    Google Scholar 

  • Myers, W. G.: Radioiodine-123 for medical research and diagnosis. In: Lawrence, J. H. (ed.), Recent Advances in Nuclear Medicine, vol. 4, p. 131. New York: Grune & Stratton 1974

    Google Scholar 

  • Myers, W. G., Anger, H. O., Lamb, J. F., Winchell, H. S.: Radioiodine-123 for applications in diagnosis. In: Proceedings of a Symposium on New Developments in Radiopharmaceuticals and labelled Compounds, vol. I, p. 249. Vienna: International Atomic Energy Agency 1973

    Google Scholar 

  • Nishiyama, H., Sodd, V. J., Ashare, A. B., Berke, R. A., Saenger, E. L.: Comparison of collimator and clinical value for123I and131I for thyroid disease. J. Nucl. Med.14, 434 (1973)

    Google Scholar 

  • Schimmelpfennig, K., Kaul, A., Haberland, U.: A method for evaluating an experimental athyreosis. Acta Endocrinologica70, 289 (1972)

    Google Scholar 

  • Smith, R. N., Wilson, G. M.: Clinical trial of different doses of131I in treatment of thyrotoxicosis. Brit. Med. J.1, 129 (1967)

    Google Scholar 

  • Solomon, D. H.: Treatment of hyperthyroidism with antithyroid drugs. In: Werner, S. C., Ingbar, S. H. (eds.). The Thyroid, p. 682. New York: Harper & Row, Publishers 1971

    Google Scholar 

  • Stanley, M. M., Astwood, E. B.: Determination of the relative activities of antithyroid compounds in man using radioactive iodine. Endocrinology41, 66 (1947)

    Google Scholar 

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Authors and Affiliations

  1. Klinik für Radiologie, Nuklearmedizin and Physikalische Therapie, Physik and Strahlenschutz (Biophysik), Klinikum Steglitz der Freien Universität Berlin, Hindenburgdamm 30, D-1000, Berlin 45

    A. R. Reddy & A. Kaul

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  1. A. R. Reddy
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  2. A. Kaul
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Alexander von Humboldt Fellow, on leave from Institute of Nuclear Medicine and Allied Sciences, Delhi -7, India

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Reddy, A.R., Kaul, A. Effect of methyl thiouracil on radioiodine thyroidal retention in rats. Radiat Environ Biophys 16, 347–354 (1979). https://doi.org/10.1007/BF01340572

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  • DOI: https://doi.org/10.1007/BF01340572

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