Radiation and Environmental Biophysics

, Volume 13, Issue 2, pp 125–135 | Cite as

Late modifications of cephalic circulation in head X-irradiated rats

  • A. Keyeux


A non-invasive and quantitative radioisotope method was applied to the assessment of late cephalic circulatory changes occurring 12 and 21 months after head irradiation at 500, 1000 or 1500 R in rats of two inbred strains. Analysis of the results concerning the tracer circulatory mean transit-time\(\left( {\bar t} \right)\) as well as those of two indices measuring respectively the cephalic blood volume (VH) and the cephalic blood flow (FH), led us to conclude that:
  • the radiation-induced late changes in cephalic circulation are more relevant to a reduction of the volume of blood flowing in the head than to a reduction of its rate

  • even a dose as low as 500 R induces such a late effect but the delay is longer than one year

  • a depression of the cardiac output can be an additional very late consequence of head irradiation

  • there is an influence of the rat strain on the temporal development of the late cephalic circulatory changes.


Blood Flow Depression Cardiac Output Blood Volume Temporal Development 
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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • A. Keyeux
    • 1
  1. 1.Faculté de MédecineUnité de Radiobiologie, Université Catholique de LouvainBruxellesBelgique

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