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Radiation and Environmental Biophysics

, Volume 13, Issue 2, pp 125–135 | Cite as

Late modifications of cephalic circulation in head X-irradiated rats

  • A. Keyeux
Article

Summary

A non-invasive and quantitative radioisotope method was applied to the assessment of late cephalic circulatory changes occurring 12 and 21 months after head irradiation at 500, 1000 or 1500 R in rats of two inbred strains. Analysis of the results concerning the tracer circulatory mean transit-time\(\left( {\bar t} \right)\) as well as those of two indices measuring respectively the cephalic blood volume (VH) and the cephalic blood flow (FH), led us to conclude that:
  • the radiation-induced late changes in cephalic circulation are more relevant to a reduction of the volume of blood flowing in the head than to a reduction of its rate

  • even a dose as low as 500 R induces such a late effect but the delay is longer than one year

  • a depression of the cardiac output can be an additional very late consequence of head irradiation

  • there is an influence of the rat strain on the temporal development of the late cephalic circulatory changes.

Keywords

Blood Flow Depression Cardiac Output Blood Volume Temporal Development 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • A. Keyeux
    • 1
  1. 1.Faculté de MédecineUnité de Radiobiologie, Université Catholique de LouvainBruxellesBelgique

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