Summary
An alternative approach to the explanation and analysis of post-irradiation effects is presented. The analysis is based on the repair of a radiation-induced lesion and it is shown that the experimental results are compatible with the repair of one type of critical lesion involved in cell reproductive death. The nature of the lesion with respect to potentially lethal damage and sub-lethal damage is discussed.
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Bacchetti, S., Cassandro, M., Elli, R., Falchetti, R., Mauro, F.: Relationship between recovery from sublethal damage by dose fractionation and the restoration of viability after delayed plating in diploidSaccharomyces cerevisiae. Radiat. Res.29, 295–315 (1966)
Burrell, A. D., Feldschreiber, P., Dean, C. J.: DNA-membrane association and the repair of double breaks in X-irradiatedMicrococcus radiodurans. Biochim. biophys. Acta (Amst.)247, 38–53 (1971)
Chadwick, K. H., Leenhouts, H. P.: A molecular theory of cell survival. Phys. in Med. Biol.18, 78–87 (1973)
Corry, P. M., Cole, A.: Double strand rejoining in mammalian DNA. Nature (Lond.) New. Biol.245, 100–101 (1973)
Elkind, M. M., Sutton-Gilbert, H., Moses, W. B., Kamper, C.: Sublethal and lethal radiation damage. Nature (Lond.)214, 1088–1092 (1967)
Elkind, M. M., Kamper, C., Moses, W. B., Sutton-Gilbert, H.: Sublethal-lethal radiation damage and repair in mammalian cells. In: Recovery and repair mechanisms in radio-biology. Brookhaven Symp. in Biol.20, 134–160 (1967)
Elkind, M. M.: Damage and repair processes relative to neutron (and charged particle) irradiation. Current topics in radiation research quarterly, Vol. VII, pp. 1–44 (M. Ebert, A. Howard,Eds.). Amsterdam: North Holland 1970
Fox, M., Nias, A. H. W.: The influence of recovery from sublethal damage on the response of cells to protracted irradiation at low dose-rate. Current topics in radiation research quarterly, Vol. VII, pp. 71–103 (M. Ebert, A. Howard,Eds.). Amsterdam: North Holland 1970
Hahn, G. M., Little, J. B.: Plateau-phase cultures of mammalian cells: An in vitro model for human cancer. Current topics in radiation research quarterly, Vol. VIII, pp. 39–83 (M. Ebert, A. Howard,Eds.). Amsterdam: North Holland 1973
Hahn, G. M., Bagshaw, M. A., Evans, R. G., Gordon, L. F.: Repair of potentially lethal lesions in X-irradiated, density-inhibited Chinese hamster cells: Metabolic effects and hypoxia. Radiat. Res.55, 280–290 (1973)
Kitayama, S., Matsuyama, A.: Possibility of the repair of double-strand scissions inMicrococcus radiodurans DNA caused by gamma-rays. Biochem. biophys. Res. Commun.33, 418–422 (1968)
Lett, J. T., Caldwell, I., Little, J. G.: Repair of X-ray damage to the DNA inMicrococcus radiodurans: The effect of 5-bromodeoxyuridine. J. molec. Biol.48, 395–408 (1970)
Little, J. B.: Repair of potentially-lethal radiation damage in mammalian cells: enhancement by conditioned medium from stationary cultures. Int. J. Radiat. Biol.20, 87–92 (1971)
Little, J. B.: Factors influencing the repair of potentially lethal radiation damage in growth-inhibited human cells. Radiat. Res.56, 320–333 (1973)
Lyman, J. T., Haynes, R. H.: Recovery of yeast after exposure to densely ionizing radiation. Radiat. Res. Suppl.7, 222–230 (1967)
Patrick, M. H., Haynes, R. H., Uretz, R. B.: Dark recovery phenomena in yeast: I. Comparative effects with various inactivating agents. Radiat. Res.21, 144–163 (1964)
Patrick, M. H., Haynes, R. H.: Dark recovery phenomena in yeast: II. Conditions that modify the recovery process. Radiat. Res.23, 564–579 (1964)
Petrovic, D., Ferle-Vidovic, A., Habazin, V., Vukovic, B.: New evidence concerning the molecular basis of the restorative effect of DNA in cultured mammalian cells. Int. J. Radiat. Biol.18, 243–258 (1970)
Phillips, R. A., Tolmach, L. J.: Repair of potentially lethal damage in X-irradiated HeLa cells. Radiat. Res.29, 413–432 (1966)
Sankaranarayanan, K.: The effects of oxygen and nitrogen post-treatments on the mortality ofDrosophila eggs irradiated as stage-7 oocytes. Mutation Res.7, 357–368 (1969)
Sankaranarayanan, K.: The effects of oxygen and nitrogen post-treatments on the survival of irradiated stage-14 oocytes and a possible basis for sensitivity differences between stage-7 and stage-14 oocytes ofDrosophila melanogaster. Mutation Res.7, 369–383 (1969)
Weiss, B. G., Tolmach, L. J.: Modification of X-ray-induced killing of HeLa S3 cells by inhibitors of DNA synthesis. Biophys. J.7, 779–795 (1967)
Winans, L. F., Dewey, W. C., Dettor, C. M.: Repair of sublethal and potentially lethal X-ray damage in synchronous Chinese hamster cells. Radiat. Res.52, 333–351 (1972)
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Chadwick, K.H., Leenhouts, H.P. The repair of potentially lethal damage: An alternative approach. Radiat Environ Biophys 11, 319–325 (1975). https://doi.org/10.1007/BF01326754
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DOI: https://doi.org/10.1007/BF01326754