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Metabolic and dosimetric studies after inhalation of227Th in rats with regard to the risk of lung and bone tumors

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Summary

227Th (α-emitter, half-life 18.7 days) was inhaled by rats from solution in nitrate form. Organ doses were calculated after whole body measurements and measuring of activity concentrations in the organs over a longer incorporation period. An initial deposition of 100 nCi227Th in the lung resulted in mean total doses of 150 rad in lung and 36 rad in bone. The data for kidney and liver were 2 rad and 0.1 rad, respectively.

For long-term experiments two dosages were applied to two groups of animals with mean values of 900 rad and 300 rad in the lung. The consequences for lung and bone tumor induction are discussed.

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References

  1. Becker, G., Pömsl, H., Luz, A.: Changes of cell population in osteogenic tissue after incorporation of227Th. 9th Annual Meeting of the European Society for Radiation Biology, Rome 1972. Book of Abstracts, p. 13

  2. EURATOM-Annual-Report: Toxicologie de certains éléments chez les animaux et chez l'homme. Programme Biology - Health Protection, pp. 457–464. Brussels: Commission of the European Communities 1973

  3. Gössner, W., Hindringer, B., Hug, O., Luz, A., Müller, W. A.: Early and late effects of incorporated224Ra in mice. In: Contamination by bone-seeking radionuclides and radio-protection, pp. 528–548. Paris 1971

  4. Gössner, W., Hindringer, B., Hug, O., Luz, A., Müller, W. A.: Tumor induction in mice after incorporation of227Th. 8th Annual Meeting of the European Society for Radiation Biology, Book of Abstracts, p. 50. Basko-Polje (Yugoslavia) 1971

    Google Scholar 

  5. HANFORD Symposium on the Biological Implications of the Transuranium Elements, Richland, Wash. Proceedings published in Hlth. Phys.22, Nr. 6 (1972)

    Google Scholar 

  6. Lafuma, J.: Mesure précise de la radioactivité d'animal vivant. J. Radiol. Électrol.43, 409 (1962)

    Google Scholar 

  7. Lafuma, J., Nenot, J. C., Morin, M., Masse, R., Metivier, H., Nolibé, D., Skupinski, W.: Respiratory carcinogenesis in rats after inhalation of radioactive aerosols of actinides and lanthanides in various physicochemical forms. Proceedings of the Congress: Experimental Respiratory Carcinogenesis and Bioassays, Seattle, 23/26 June 1974 (in press)

  8. Lafuma, J., Chameaud, H., Perrault, R., Masse, R., Nenot, J. C., Morin, M.: Etude expérimental de la comparaison de l'action toxique sur les poumons du222Rn et de ses produits de filiation avec les émetteurs de la série des actinides. Congrès sur “La radio-protection dans l'extraction et le traitement de l'uranium et du thorium”, Communication Nr. 12, Bordeaux, 9/11 Septembre 1974 (in press)

  9. Luz, A., Müller, W. A., Gössner, W., Hindringer, B., Hug, O.: The role of dose and dose protraction for the induction of osteosarcomas after incorporation of short-livedα-emitting bone-seekers. 9th Annual Meeting of the European Society for Radiation Biology, Book of Abstracts, p. 103. Rome 1972

  10. Müller, W. A.: Praparative Arbeiten über227Ac und seine Folgeprodukte. Radiochimica Acta9, 181–186 (1968)

    Google Scholar 

  11. Müller, W. A.: Studies on short-lived internal α-emitters in mice and rats. Part II:227Th. Int. J. Radiat. Biol.20, 233–243 (1971)

    Google Scholar 

  12. Müller, W. A., Gössner, W., Hug, O., Luz, A.: Late effects after incorporation of the short-lived α-emitters224Ra and227Th in mice. Proceedings of the International Symposium on “Biological Effects of Injected224Ra and Thorotrast. Alta, Utah (USA) 1974, Hlth. Phys. (in press)

    Google Scholar 

  13. Nenot, J. O., Morin, M., Lafuma, J.: Etude métabolique et thérapeutique des contaminations respiratoires par certains actinides en solutions. Hlth. Phys.20, 167–177 (1971)

    Google Scholar 

  14. Spiess, H., Mays, C. W.: Bone cancers induced by224Ra (ThX) in children and adults. Hlth. Phys.20, 713–729 (1971)

    Google Scholar 

  15. Spiess, H., Mays, C. W.: Protraction effect on bone-sarcoma induction of224Ra in children and adults. In: Radionuclide Carcinogenesis, USAEC, Conf- 720505, pp. 437–450 (1973)

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Authors and Affiliations

  1. Institut für Biologie der Gesellschaft für Strahlen- u. Umweltforschung mbH, Neuherberg

    W. A. Müller

  2. Département de Protection, Centre d'Études Nucléaires, Boîte Postale 6, 92260, Fontenay-aux-Roses, France

    J. C. Nenot, M. L. Daburon & J. Lafuma

  3. Abt. f. Strahlenbiologie und Biophysik des Instituts für Biologie, Gesellschaft für Strahlen- und Unrweltforschung mbH, Ingolstädter Landstr. 1, D-8042, Neuherberg, Federal Republic of Germany

    W. A. Müller

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  1. W. A. Müller
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  2. J. C. Nenot
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  3. M. L. Daburon
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  4. J. Lafuma
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In association with EURATOM (contract-Nrs. 090-72-1 BIAD and 100-72-1 BIAF).

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Müller, W.A., Nenot, J.C., Daburon, M.L. et al. Metabolic and dosimetric studies after inhalation of227Th in rats with regard to the risk of lung and bone tumors. Radiat Environ Biophys 11, 309–318 (1975). https://doi.org/10.1007/BF01326753

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  • DOI: https://doi.org/10.1007/BF01326753

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