Summary
The prognosis of patients with malignant melanoma and brain metastases is poor. Therapy of brain metastases is difficult and mostly unsuccessful, with brain metastases being the predominant factor which determines overall survival. We report here on a patient whose brain metastases responded to DTIC+INF-gamma. We present a short summary on the different effects on INF-alpha and INF-gamma and reach the conclusion that clinical trials which combine DTIC and INF-gamma should be performed. Based on this observation, combinations including INF-alpha are not necessarily comparable to modalities which include INF-gamma.
Similar content being viewed by others
References
Merimsky O, Inbar M, Reider-Groswasser I, Chaitchik S: Brain metastases of malignant melanoma in interferon complete responders: clinical and radiological observations. J Neuro-Oncol 12: 137–140, 1992
Tveit KM, Endresen L, Rugstad HE, Fodstad O, Pihl A: Comparison of two soft-agar methods for assaying chemosensitivity of human tumoursin vitro: malignant melanomas. Br J Cancer 44: 539–544, 1981
Castello G, Ruocco V, Satriano RA, Zarrilli D: Role of interferons in the therapy of melanoma. Melanoma Res 1: 311–325, 1991
Mannering GJ, Deoria LB: The pharmacology and toxicology of the interferons: an overview. Ann Rev Pharmacol Toxicol 26: 455–515, 1986
Creagan ET: Interferon trials in the management of malignant melanoma and other neoplasms: an overview. Cancer Treat Res 35: 167–194, 1987
Hersey P, McLeod GR, Thomson DB: Treatment of advanced malignant melanoma with recombinant interferon alfa-2a in combination with DTIC. Brit J Haematol 79 (Suppl I) 60–66, 1991
Ho VC, Sober AJ: Therapy for cutaneous melanoma: An update. J Am Acad Dermatol 22: 159–176, 1990
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Schadendorf, D., Worm, M. & Czarnetzki, B.M. Brain metastases of metastatic malignant melanoma: Response to DTIC and interferon-gamma. J Neuro-Oncol 16, 77–79 (1993). https://doi.org/10.1007/BF01324838
Issue Date:
DOI: https://doi.org/10.1007/BF01324838