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Pituitary oncocytomas: clinical features, characteristics in cell culture, and treatment recommendations

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Abstract

To determine whether there are significant differences between oncocytomas and pituitary adenomas, we evaluated clinical features, treatment regimens and outcome in 23 males and 9 females (average age 64 years, range 43–81 years) with the histologic diagnosis of pure pituitary oncocytomas (>95% oncocytes). Symptom duration was six to twelve months in 6 cases (19%) and more than one year in 19 cases (59%). Three patients presented with sudden onset of symptoms, and were found to have hemorrhage within their tumors. Visual loss (69%) and symptoms of hypopituitarism (44%) were the most common presenting complaints. Preoperative endocrine profiles revealed abnormalities in most cases, including pituitary insufficiency in 56% and hyperprolactinemia in 59%. The tumors were typically large at presentation; all but one had suprasellar extension. 28 patients underwent transsphenoidal tumor resections; 4 underwent subfrontal craniotomies. Gross dural invasion was found at surgery in 11 cases. At a mean followup of 31 months (range 2–68 months), recurrent tumor was identified in 4 patients (12.5%). Tumor size, dural invasion, preoperative endocrine profile, and postoperative radiotherapy did not correlate with recurrence. Among seven oncocytomas grown in culture, five demonstrated two distinct cell types consisting of oncocytes and typical adenoma cells, respectively. Oncocytomas often have a different clinical presentation than functional pituitary adenomas.

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References

  1. Aguilar-Parada E, Gonzalez-Angulo A, Zarate A, Loyo M, Moran C, Gonzalez-Barcena D, Perez-Hernandez U: High incidence of non-functioning oncocytomas in pituitary adenomas (ultrastructural study). Arch Invest Med (Mexico) 16: 247–254, 1985

    Google Scholar 

  2. Ali-Osman, Spence AM, Berger MS, Caughlan J: Primary cultures of human glial tumors and their relationship to histopathology. Neuropath Exp Path 46: 371, 1987

    Google Scholar 

  3. Asa SL:In vitro studies of human pituitary adenomas. Pathol Res Pract 183: 561–564, 1988

    Google Scholar 

  4. Asa SL, Gerrie BM, Singer W, Horvath E, Kovacs K, Smyth: Gonadotropin secretionin vitro by human pituitary null cell adenomas and oncocytomas. J Clin Endocrinol Metab 62: 1011–1019, 1986

    Google Scholar 

  5. Baskin DS, Boggan JE, Wilson CB: Transsphenoidal microsurgical removal of growth hormone-secreting pituitary adenomas: A review of 137 cases. J Neurosurg 56: 634–641, 1982

    Google Scholar 

  6. Bauserman SC, Hardman JM, Schochet SS Jr, Earle KM: Pituitary oncocytoma: Indispensable role of electron microscopy in its identification. Arch Pathol Lab Med 102: 456–491, 1978

    Google Scholar 

  7. Black PM, Hsu DW, Klibanski A, Kliman B, Jameson JL, Ridgway EC, Hedley-Whyte T, Zervas: Hormone production in clinically nonfunctioning pituitary adenomas. J Neurosurg 66: 244–250, 1987

    Google Scholar 

  8. De Stephano DB, Lloyd RV, Pike AM, Wilson BS: Pituitary adenomas: An immunocytochemical study of hormone production and chromogranin localization. Amer J Pathol 116: 464–472, 1984

    Google Scholar 

  9. Diehl S, Weber T, Hamester U, Saeger W, Lüdecke DK: Light microscopical morphometric classification of oncocytic and chromophobe pituitary adenomas. Exp Clin Endocrinol 91: 341–349, 1988

    Google Scholar 

  10. Farmer PM: Electron microscopy in the diagnosis of pituitary tumors. Ann Clin Lab Sci 9: 275–288, 1979

    Google Scholar 

  11. Gjerris A, Lindholm J, Riishede J: Pituitary oncocytic tumor with Cushing's disease. Cancer 42: 1818–1822, 1978

    Google Scholar 

  12. Goebel HH, Schulz F, Rama B: Ultrastructurally abnormal mitochondria in the pituitary oncocytoma. Acta Neurochir (Wien) 51: 195–201, 1980

    Google Scholar 

  13. Günzl HJ, Saeger W, Diehl S, Lüdecke DK: Immunocytochemical analyses of oncocytic and chromphobe adenomas. Exp Clin Endocrinol 92: 51–58, 1988

    Google Scholar 

  14. Halberg FE, Sheline GE: Radiotherapy of pituitary tumors. In: Moloitch ME (ed) Endocrinology and Metabolism of Clinics of North America, Vol 16(3), W.B. Saunders Co., Philadelphia 667–684, 1987

    Google Scholar 

  15. Hamperl H: Benign and malignant oncocytoma. Cancer 15: 1019–1027, 1962

    Google Scholar 

  16. Hamperl H: Onkocyten and geschwültse der Speicheldrüsen. Virchow Arch [Pathol Anat] 282: 724–736, 1931.

    Google Scholar 

  17. Horvath E, Kovacs K, Killinger DW, Smyth HS, Platts, Singer W: Silent corticotropic adenomas of the human pituitary gland: A histological, immunocytologic, and ultrastructural study. Amer J Pathol 98: 617–638, 1980

    Google Scholar 

  18. Jalalah S, Horvath E, Kovacs K: Electron dense mitochondrial inclusions in a pituitary oncocytoma. J Submicrosc Cytol 17: 667–671, 1985

    Google Scholar 

  19. Kalyanaraman UP, Halmi NS, Elwood PW: Prolactin-secreting pituitary oncocytoma with galactorrhea-amenorrhea syndrome: a histologic, ultrastructural and immunocytochemical study. Cancer 46: 1584–1589, 1980

    Google Scholar 

  20. Kliblanski A: Nonsecreting pituitary tumors. In: Moloitch ME (ed) Endocrinology and Metabolism of Clinics of North America, Vol 16(3), W.B. Saunders Co., Philadelphia 793–804, 1987

    Google Scholar 

  21. Kovacs K, Horvath E: Pathology of pituitary adenomas. Bull Los Angeles Neurol Soc 42: 92–110, 1977

    Google Scholar 

  22. Kovacs K, Horvath E: Pathology of pituitary tumors. In: Moloitch ME (ed) Endocrinology and Metabolism of Clinics of North America, Vol 16(3), W.B. Saunders Co., Philadelphia 529–551, 1987

    Google Scholar 

  23. Kovacs K, Horvath E, Ryan N, Ezrin C: Null cell adenoma of the human pituitary. Virchow Arch [Pathol Histol] 387: 165–174, 1980

    Google Scholar 

  24. Landolt AM, Oswald UW: Histology and ultrastructure of an oncocytic adenoma of the human pituitary. Cancer 31: 1099–1105, 1973

    Google Scholar 

  25. Laws ER: Pituitary surgery. In: Moloitch ME (ed) Endocrinology and Metabolism of Clinics of North America, Vol 16(3), W.B. Saunders Co., Philadelphia 647–666, 1987

    Google Scholar 

  26. Laws ER, Peipgras DG, Randall RV: Neurosurgical management of acromegally: Results in 82 patients treated between 1972 and 1977. J Neurosurg 50: 454–461, 1979

    Google Scholar 

  27. Lipson LG, Beitins IZ, Kornblith PD, McArthur JW, Friesen HG, Kliman B, Kjellberg RN: Tissue culture studies on human pituitary tumours: Radioimmunassayable anterior pituitary hormones in the culture medium. Acta Endocrinol 88: 239–249, 1978

    Google Scholar 

  28. Mashiter K, Adams E, Van Noorden S: Secretion of LH, FSH and PRL shown by cell culture and immunocytochemistry of human functionless pituitary adenomas. Clin Endocrinol. 15: 103–112, 1981

    Google Scholar 

  29. Okoye MI, Mueller WF Jr: Invasive pituitary oncocytoma. J Natl Med Assoc 75: 1215–1219, 1983

    Google Scholar 

  30. Pistenma DA, Goffinet DR, Bagshaw MA, Hanbery JW, Eltringham JR: Treatment of chomophobe adenomas with megavoltage irradiation. Cancer 35: 1574–1582, 1975

    Google Scholar 

  31. Roy S: Ultrastructure of oncocytic adenoma of the human pituitary gland. Acta Neuropathol 41: 169–171, 1978

    Google Scholar 

  32. Ryder DR, Horvath E, Kovacs K: Fine structural features of secretion in pituitary adenomas of the pituitary gland. Arch Pathol Lab Med 104: 518–521, 1980

    Google Scholar 

  33. Scanarini M, Mingrino S: Clinical, histological and ultrastructural observations upon the oncocytoma of the human pituitary gland. J Neurosurg Sci 18: 263–267, 1974

    Google Scholar 

  34. Scheithauer BW, Kaiman KT, Laws ER, Randall RV: Pathology of invasive pituitary tumors with special reference to functional classification. J Neurosurg 65: 733–744, 1986

    Google Scholar 

  35. Selman WR, Laws ER, Scheithauer BW, Carpenter SM: The occurence of dural invasion in pituitary adenomas. J Neurosurg 64: 402–407, 1986

    Google Scholar 

  36. Tremblay G: The oncocytes. Meth Acheiv Exp Pathol 4: 121–140, 1969

    Google Scholar 

  37. Weber T, Saeger W, Lüdecke DK: Light microscopical morphometry, immunocytochemistry, and clinical correlations of pituitary adenomas at the various stages of oncocytic transformation. Acta Endocrinol (Copenh) 116: 489–496, 1987

    Google Scholar 

  38. Wilson CB: A decade of pituitary microsurgery. The Olivecrona lecture. J Neurosurg 61: 814–833, 1984

    Google Scholar 

  39. Yamada S, Asa SL, Kovacs: Oncocytomas and null cell adenomas of the human pituitary: morphometric andin vitro functional comparison. Virchow Arch A Pathol Anat Histopathol 413: 333–339, 1988

    Google Scholar 

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Authors and Affiliations

  1. Department of Neurological Surgery, University of Washington Medical Center, Seattle, Washington

    Daniel L. Silbergeld, Marc R. Mayberg, Mitchel S. Berger, Francis Ali-Osman, William A. Kelly & Cheng -Mei Shaw

  2. Department of Neurological Surgery, Washington University Medical Center, St. Louis, Missouri

    Daniel L. Silbergeld

  3. Department of Experimental Pediatrics, Section of Experimental Therapeutics, University of Texas, MD

    Francis Ali-Osman

  4. Anderson Cancer Center, Houston, Texas

    Francis Ali-Osman

  5. Department of Pathology, Division of Neuropathology, University of Washington Medical Center, Seattle, Washington, USA

    Cheng -Mei Shaw

Authors
  1. Daniel L. Silbergeld
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  2. Marc R. Mayberg
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  3. Mitchel S. Berger
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  4. Francis Ali-Osman
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  5. William A. Kelly
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  6. Cheng -Mei Shaw
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Silbergeld, D.L., Mayberg, M.R., Berger, M.S. et al. Pituitary oncocytomas: clinical features, characteristics in cell culture, and treatment recommendations. J Neuro-Oncol 16, 39–46 (1993). https://doi.org/10.1007/BF01324833

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