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Effect of ursodeoxycholic acid administration on biliary lipid composition and bile acid kinetics in cholesterol gallstone patients

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Abstract

The effect of ursodeoxycholic acid (UDCA) on bile lipid composition and bile acid kinetics was evaluated in seven cholesterol gallstone patients following one month of UDCA administration (12 mg/kg/day). UDCA administration induces a significant reduction in the cholesterol saturation index (SI). After UDCA treatment, UDCA becomes the predominant biliary bile acid while chenodeoxycholic, cholic, and deoxycholic acid are significantly reduced. UDCA pool significantly increases, and chenodeoxycholic, cholic, and total bile acid pools significantly decrease. The reduction in bile lithogenicity during UDCA administration suggests that UDCA may be useful for cholesterol gallstone treatment in man.

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Authors and Affiliations

  1. Department of Gastroenterology, S. Orsola Hospital, and Institute of Chemistry “G. Ciamician”, University of Bologna, Via Massarenti n. 9, 40100, Bologna, Italy

    Enrico Roda MD, Aldo Roda PhD, Claudia Sama MD, Davide Festi MD, Giuseppe Mazzella MD, Rita Aldini MD & Luigi Barbara MD

Authors
  1. Enrico Roda MD
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  2. Aldo Roda PhD
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  3. Claudia Sama MD
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  4. Davide Festi MD
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  5. Giuseppe Mazzella MD
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  6. Rita Aldini MD
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  7. Luigi Barbara MD
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Roda, E., Roda, A., Sama, C. et al. Effect of ursodeoxycholic acid administration on biliary lipid composition and bile acid kinetics in cholesterol gallstone patients. Digest Dis Sci 24, 123–128 (1979). https://doi.org/10.1007/BF01324739

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