Summary
The treatment of recurrent malignant glioma is difficult and at present largely disappointing. Furthermore the results of any treatment modality need to be interpreted with knowledge regarding patient selection and timing of treatment. The results of interstitial brachytherapy using iodine-125 in 23 patients are presented. There were no operative complications. Median survival time from tumour recurrence and implantation was 36 and 25 weeks respectively. Karnofsky Performance Status (KPS) was significantly associated with survival, though patient age, original tumour histology, prior chemotherapy, and time to recurrence were not. Treatment does confer modest survival benefit as compared to controls, but our results are not as impressive as others. Reasons for this finding are discussed.
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References
Bernstein M, Laperierre N, Leung P, McKenzie S: Interstitial brachytherapy for malignant brain tumours: preliminary results. Neurosurgery 26: 371–380, 1990
Florell RC, Macdonald DR, Irish WD, Bernstein M, Leibel SA, Gutin PH, Cairncross JG: Selection bias, survival, and brachytherapy for glioma. J Neurosurg 76: 179–183, 1992
Loeffler JS, Alexander III E, Wen PY, Shea WM, Coleman CN, Kooy HM, Fine HA, Nedzi LA, Silver B, Riese NE, Black PM: Results of stereotactic brachytherapy used in the initial management of patients with glioblastoma. J Nat Can Instit 82: 1918–1921, 1990
Ostertag ChB, Kreth FW: Iodine-125 Interstitial Irradiation for cerebral gliomas: Acta Neurochir (Wien) 119: 53–61, 1992
Bernstein M, Laperriere NJ: A critical appraisal of the role of brachytherapy for pediatric brain tumors. Pediatr Neurosurg 16: 213–218, 1990–1991
Sofat A, Hughes SW, Beaney R, Thomas DGT: Iodine-125 brachytherapy for recurrent malignant glioma. Brit J Neurosurg 5: 434, 1991
Sofat A, Hughes S, Briggs J, Beaney RP, Thomas DGT: Stereotactic brachytherapy for malignant glioma using a relocatable frame. B J Neurosurg 6: 543–548, 1992
Gutin PH, Dormandy RH: A coaxial catheter system for afterloading radioactive sources for the interstitial irradiation of brain tumours. J Neurosurg 56: 734–735, 1982
Gill S, Thomas DGT: A relocatable frame. J Neurol Neurosurg Psychiatry 52: 1460–1461, 1989
Gutin PH, Phillips TL, Wara WM, Leibel SA, Hosbuchi Y, Levin VA, Weaver KA, Lamb S: Brachytherapy of recurrent malignant brain tumours with removable iodine-125 sources. J Neurosurg 60: 61–68, 1984
Leibel SA, Gutin PH, Wara WM, Silver PS, Larson DA, Edwards MSB, Lamb SA, Ham B, Weaver KA, Barnett C, Phillips TL: Survival and quality of life after interstitial implantation of removable high activity iodine-125 sources for the treatment of patients with recurrent malignant gliomas. Int J Rad Onc Biol Phys 17: 1129–1139, 1989
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Kitchen, N.D., Hughes, S.W., Taub, N.A. et al. Survival following interstitial brachytherapy for recurrent malignant glioma. J Neuro-Oncol 18, 33–39 (1994). https://doi.org/10.1007/BF01324601
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DOI: https://doi.org/10.1007/BF01324601