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Oxygenation of malignant tumors after localized microwave hyperthermia

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Summary

The oxyhemoglobin saturation (HbO2) of single red blood cells within tumor microvessels (diameter: 3–12 µm) of DS-Carcinosarcoma was studied using a cryophotometric micromethod. In untreated control tumors (mean tissue temperature approx. 35° C) the measured values scattered over the whole saturation range from zero to 100 sat.%, the mean being 51 sat.%. Upon heating at 40° C for 30 min, the oxygenation of the tumor tissue significantly improved as compared with control conditions. After 40° C-hyperthermia a mean oxyhemoglobin saturation of 66 sat.% was obtained. In contradistinction to this, after 43° C-hyperthermia the tumor oxygenation was significantly lower and reached a mean HbO2 saturation value of 47 sat.%. A further temperature rise to 45° C caused the oxygenation to drop drastically (mean oxyhemoglobin saturation value: 24 sat.%). This is due to a severe restriction of nutritive blood flow.

The changes in tumor oxygenation after hyperthermia seem to be predominantly mediated through changes in tumor blood flow, including tumor microcirculation, which showed a similar temperature dependence. Metabolic effects probably play a minor role in the oxyhemoglobin saturation distribution within tumor microvessels.

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Authors and Affiliations

  1. Physiologisches Institut der Universität Mainz, Saarstraße 21, D-6500, Mainz, Germany

    Peter W. Vaupel (Prof.) & Johannes Otte

  2. Physiologisches Institut der Universität, D-8400, Regensburg, Germany

    Rolf Manz

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  1. Peter W. Vaupel
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  2. Johannes Otte
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  3. Rolf Manz
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Vaupel, P.W., Otte, J. & Manz, R. Oxygenation of malignant tumors after localized microwave hyperthermia. Radiat Environ Biophys 20, 289–300 (1982). https://doi.org/10.1007/BF01323754

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  • DOI: https://doi.org/10.1007/BF01323754

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