Summary
Cellular survival results for late-S Chinese hamster V79 cells exposed to triads of protons of variable mean separations are reported. The data are analyzed within the framework of the Theory of Dual Radiation Action [8]. This analysis provides a new estimation of the function γ(x) representing the probability of two energy transfers separated by the distancex to produce a lesion. In agreement with an earlier study [6] involving pairs of deuterons, it is concluded that:a) the process of lesion formation depends strongly on the relative separation of energy deposition events, andb) intratrack and intertrack lesions correspond to substantially different separations of pairwise energy transfers.
Similar content being viewed by others
References
Bird RP (1979) Biophysical studies with spatially correlated ions. 3. Cell survival studies using diatomic deuterium. Radiat Res 78: 210–233
Brenner DJ, Zaider M (1982) The soft x ray experiment revisited - A theoretical analysis. In: Booz J, Ebert H (eds) Proc. of the Eight Symposium on Microdosimetry, Jülich, Fed. Rep. of Germany, pp 639–649
Colvett RD, Rohrig N (1979) Biophysical studies with spatially correlated ions. 2. Multiple scattering, experimental facility, and dosimetry. Radiat Res 78: 192–209
Haskell KH, Hanson RJ (1979) Selected algorithms for the linearly constrained least squares problem - A user's guide. Sand 78-1290, Sandia Laboratories, Albuquerque, N.M.
Kellerer AM, Chmelevsky D (1975) Concepts of microdosimetry. III. Mean values of the microdosimetric distributions. Radiat Environ Biophys 12: 321–335
Kellerer AM, Lam YP, Rossi HH (1980) Biophysical studies with spatially correlated ions. 4. Analysis of cell survival data for diatomic deuterium. Radiat Res 83: 522–528
Kellerer AM, Rossi HH (1972) The theory of dual radiation action. Curr Top Radiat Res Q 8: 85–158
Kellerer AM, Rossi HH (1978) A generalized formulation of dual radiation action. Radiat Res 75: 471–488
Rossi HH (1979) Biophysical studies with spatially correlated ions. 1. Background and theoretical considerations. Radiat Res 78: 185–191
Rossi HH (1967) Microscopic energy distribution in irradiated matter. In: Radiation dosimetry, vol 1. Academic Press, New York, pp 43–92
Rossi HH, Kellerer AM (1974) Biological implications of microdosimetry. 1. Temporal aspects. In: Booz J, Ebert H, Eickel R, Walker W (eds) Proc. of the Fourth Symposium on Microdosimetry, Verbania-Pallazo, Italy, EUR 5122 d-e-f, p 315
Zaider M, Brenner DJ (1983) Computational details of the Monte Carlo simulation of proton and electron tracks. Proc. of Workshop on Interface between Radiation Chemistry and Radiation Physics, A.N.L. Report 82-83, pp 113–120
Zaider M, Brenner DJ, Hanson K, Minerbo GN (1982) An algorithm for determining the proximity distribution from dose-averaged lineal energies. Radiat Res 91: 95–103
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Zaider, M., Bird, R.P., Rossi, H.H. et al. A study of cell survival in mammalian cells exposed to spatially correlated triads of protons. Radiat Environ Biophys 22, 239–249 (1983). https://doi.org/10.1007/BF01323675
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01323675