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On the statistical evaluation of dose-response functions

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Summary

The linear-quadratic dependence of effect on the dose of ionizing radiation and its biophysical implications are considered. The estimation of the parameters of the response function and the derivation of the joint confidence region of the estimates are described. The method is applied to the induction of pink mutations inTradescantia which follows the linear-quadratic model. The statistical procedure is also suitable for other response functions.

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Author notes

  1. J. Brenot

    Present address: Commissariat à I'Energie Atomique, DPr/Sps, Fontenay-aux-Roses, France

Authors and Affiliations

  1. Radiological Research Laboratories Department of Radiology, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, 10032, New York, N.Y., USA

    A. M. Kellerer & J. Brenot

Authors
  1. A. M. Kellerer
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  2. J. Brenot
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Dedicated to Prof. Dr. O. Hug on the occasion of his 60th birthday.

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Kellerer, A.M., Brenot, J. On the statistical evaluation of dose-response functions. Radiat Environ Biophys 11, 1–13 (1974). https://doi.org/10.1007/BF01323095

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  • DOI: https://doi.org/10.1007/BF01323095

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