Skip to main content
SpringerLink
Log in

Prophylaxis and therapy of virulent encephalomyocarditis virus infection in mice by monoclonal antibodies

  • Brief Report
  • Published:
Archives of Virology Aims and scope Submit manuscript

Summary

Two encephalomyocarditis virus (EMCV) neutralizing monoclonal antibodies (MAs), recognizing different determinants on EMCV, were both able to protect mice prophylactically and therapeutically against a lethal dose of EMCV.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Balachandran N, Bacchetti S, Rawls WE (1982) Protection against lethal challenge of BALB/c mice by passive transfer of monoclonal antibodies to five glycoproteins of herpes simplex virus type 2. Infect Immun 37: 1132–1137

    Google Scholar 

  2. Boere WAM, Benaissa-Trouw BJ, Harmsen M, Kraaijeveld CA, Snippe H (1983) Neutralizing and non-neutralizing monoclonal antibodies to the E2 glycoprotein of Semliki Forest Virus can protect mice from lethal encephalitis. J Gen Virol 64: 1405–1408

    Google Scholar 

  3. Boere WAM, Harmsen M, Vinjé J, Benaissa-Trouw B, Kraaijeveld CA, Snippe H (1984) Identification of distinct antigenic determinants on Semliki Forest virus by using monoclonal antibodies with different antiviral activities. J Virol 52: 575–582

    Google Scholar 

  4. Boere WAM, Benaissa-Trouw BJ, Harmsen T, Erich T, Kraaijeveld CA, Snippe H (1985) Mechanisms of monoclonal antibody-mediated protection against virulent Semliki Forest virus. J Virol 54: 546–551

    Google Scholar 

  5. Bogaerts WJC (1971) Respiratory immunization against EMC virus in mice. Academic Thesis, Utrecht

  6. Bogaerts WJC, Durville-van der Oord BJ (1973) Immunization of mice with live attenuated encephalomyocarditis virus: local immunity and survival. Infect Immun 8: 528–533

    Google Scholar 

  7. Carter MJ, Ter Meulen V (1984) The application of monoclonal antibodies in the study of viruses. Adv Virus Res 29: 95–130

    Google Scholar 

  8. Craighead JE (1965) Some properties of the encephalomyocarditis, Columbia SK and mengo viruses. Proc Soc Exp Biol Med 119: 408–412

    Google Scholar 

  9. Craighead JE (1975) The role of viruses in the pathogenesis of pancreatic disease and diabetes mellitus. Prog Med Virol 19: 161–214

    Google Scholar 

  10. Ey PL, Prowse SJ, Jenkin CR (1978) Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-Sepharose. Immunochemistry 15: 429–436

    Google Scholar 

  11. Fazekas de St. Groth S, Scheidegger D (1980) Production of monoclonal antibodies: strategy and tactics. J Immunol Methods 35: 1–21

    Google Scholar 

  12. Kohler G, Milstein C (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256: 495–497

    Google Scholar 

  13. Kohler G, Howe SW, Milstein C (1976) Fusion between immunoglobulin-secreting and non-secreting myeloma cell lines. Eur J Immunol 6: 292–295

    Google Scholar 

  14. Kraaijeveld CA, La Rivière G, Benaissa-Trouw BJ, Jansen J, Harmsen M, Snippe H (1983) Effect of the adjuvant dimethyl dioctadecyl ammonium bromide on the humoral and cellular immune responses to encephalomyocarditis virus. Antiviral Res 3: 137–149

    Google Scholar 

  15. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265–275

    Google Scholar 

  16. Murphy BR, Glasgow LA (1968) Factors modifying host resistance to infection. III. Effect of whole body x-irradiation in mice. J Exp Med 127: 1035–1052

    Google Scholar 

  17. Nakane PK, Kawaoi A (1974) Peroxidase-labeled antibody, a new method of conjugation. J Histochem Cytochem 22: 1084–1091

    Google Scholar 

  18. Pollock RR, Teilland JL, Scharff MD (1984) Monoclonal antibodies: a powerful tool for selecting and analyzing mutations in antigens and antibodies. Ann Rev Microbiol 38: 389–417

    Google Scholar 

  19. Putnak JR, Philips BA (1981) Picornaviral structure and assembly. Microbiol Rev 45: 287–315

    Google Scholar 

  20. Schmaljohn AL, Johnson ED, Dalrymple JM, Cole GA (1982) Non-neutralizing monoclonal antibodies can prevent lethal alphavirus encephalitis. Nature 297: 70–72

    Google Scholar 

  21. Stave JW, Card JL, Morgan DO (1986) Analysis of foot-and mouth disease virus type O1 Brugge. Neutralization epitopes using monoclonal antibodies. J Gen Virol 67: 2083–2092

    Google Scholar 

  22. Yewdell JW, Gerhard W (1981) Antigenic characterization of viruses by monoclonal antibodies. Ann Rev Microbiol 35: 185–206

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Microbiology, State University of Utrecht, Utrecht, The Netherlands

    F. Vlaspolder, C. A. Kraaijeveld, R. van Buuren, M. Harmsen, B. J. Benaissa-Trouw & H. Snippe

Authors
  1. F. Vlaspolder
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. A. Kraaijeveld
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. van Buuren
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Harmsen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. B. J. Benaissa-Trouw
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. H. Snippe
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vlaspolder, F., Kraaijeveld, C.A., van Buuren, R. et al. Prophylaxis and therapy of virulent encephalomyocarditis virus infection in mice by monoclonal antibodies. Archives of Virology 98, 123–130 (1988). https://doi.org/10.1007/BF01321013

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01321013

Keywords

Search

Navigation