Skip to main content

Advertisement

SpringerLink
Log in

Antigenic variation of equine infectious anemia virus as detected by virus neutralization

  • Brief Report
  • Published:
Archives of Virology Aims and scope Submit manuscript

Summary

The antigenic structure of 16 viruses isolated from four horses which were inoculated with a clone of equine infectious anemia (EIA) virus was compared by the neutralization test. The antigenic structure of viruses isolated after development of neutralizing antibody differed from virus to virus. Back mutation of the antigenic structure was also demonstrated by serial passage of the virus in horses. These results suggest that EIA virus is subject to multidirectional antigenic variation. The possibility that the variants originated in the heterologous virus population in the inoculum seems to be unlikely since the virus used for the primary inoculation was cloned by three repeated high-limiting dilutions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Charman HP, Braden S, Gilden RV, Coggins L (1976) Equine infectious anemia virus: evidence favoring classification as a retrovirus. J Virol 19: 1073–1079

    Google Scholar 

  2. Chiu I-M, Yamiv A, Dahlberg JE, Gazit A, Skuntz SF, Tronick SR, Aaronson SA (1985) Nucleotide sequence for relationship of AIDS retrovirus to lentiviruses. Nature 317: 366–368

    Google Scholar 

  3. Clements J, Pederson F, Narayan O, Haseltine W (1980) Genomic changes associated with antigenic variation of visna virus during persistent infection. Proc Natl Acad Sci USA 77: 4454–4458

    Google Scholar 

  4. Dalgleish A, Beverly PCL, Clapham PR, Crawford DH, Greaves MF, Weiss RA (1984) The CD4 (T 4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature 312: 763–767

    Google Scholar 

  5. Hahn BH, Shaw GM, Taylor ME, Redfield RR, Markham PD, Salahuddin SZ, Wong-Staal F, Gallo RC, Parks ES, Parks WP (1986) Genetic variation in HTLV-III/LAV over time in patients with AIDS or at risk for AIDS. Science 232: 1548–1553

    Google Scholar 

  6. Ishii S (1963) Equine infectious anemia or swamp fever. Adv Vet Sci 8: 263–298

    Google Scholar 

  7. Klatzmann D, Champagne E, Chamaret S, Gruest J, Guetard D, Hercend T, Gluckman JC, Montagnier L (1984) T-lymphocyte T 4 molecule behaves as the receptor for human retrovirus LAV. Nature 312: 767–768

    Google Scholar 

  8. Kono Y (1969) Viremia and immunological responses in horses infected with equine infectious anemia virus. Natl Inst Anim Health Q (Tokyo) 9: 1–9

    Google Scholar 

  9. Kono Y (1973) Recurrences of equine infectious anemia: approaches to an understanding of the mechanisms. In: Bryans JT, Gerber H (eds) Proc 3rd Int Conf Equine Infect Dis, Paris 1972. Karger, Basel, pp 175–186

    Google Scholar 

  10. Kono Y (1973) Development of immunity after immunization with avirulent, attenuated and virulent equine infectious anemia viruses. In: Bryans JT, Gerber H (eds) Proc 3rd Int Conf Equine Infect Dis, Paris 1972. Karger, Basel, pp 242–254

    Google Scholar 

  11. Kono Y, Fukunaga Y, Kobayashi K (1973) Resistance of horses infected chronically with equine infectious anemia virus against reinfection. Natl Inst Anim Health Q (Tokyo) 13: 173–181

    Google Scholar 

  12. Kono Y, Hirasawa K, Fukunaga Y, Taniguchi T (1976) Recrudescence of equine infectious anemia by treatment with immunosuppressive drugs. Natl Inst Anim Health Q (Tokyo) 16: 8–15

    Google Scholar 

  13. Kono Y, Kobayashi K (1966) Complement fixation test of equine infectious anemia. I. Specificity of the test. Natl Inst Anim Health Q (Tokyo) 6: 194–203

    Google Scholar 

  14. Kono Y, Kobayashi K (1967) Specificity of assay of equine infectious anemia virus in horse leukocyte culture. Natl Inst Anim Health Q (Tokyo) 8: 117–121

    Google Scholar 

  15. Kono Y, Kobayashi K, Fukunaga Y (1970) Immunization of horses against equine infectious anemia (EIA) with an attenuated EIA virus. Natl Inst Anim Health Q (Tokyo) 10: 113–122

    Google Scholar 

  16. Kono Y, Kobayashi K, Fukunaga Y (1973) Antigenic drift of equine infectious anemia virus in chronically infected horses. Arch Ges Virusforsch 41: 1–10

    Google Scholar 

  17. Kono Y, Sentsui H, Murakami Y (1976) Development of specific in vitro lymphocyte stimulation responses in horses infected with equine infectious anemia virus. Vet Microbiol 1: 31–43

    Google Scholar 

  18. Kono Y, Sentsui H, Murakami Y (1978) Lymphocyte responses to specific viral antigen and nonspecific mitogens in horses infected with equine infectious anemia virus. In: Bryans JT, Gerber H (eds) Proc 4th Int Conf Equine Infect Dis, Lyon 1976. Vet Pub Inc, Princeton, pp 363–374

    Google Scholar 

  19. McGuire TC, Crawford TB, Henson JB (1971) Immunofluorescent localization of equine infectious anemia virus in tissue. Am J Path 62: 283–292

    Google Scholar 

  20. Montelaro RC, Parekh B, Orrego A, Issel CJ (1984) Antigenic variation during persistent infection by equine infectious anemia virus, a retrovirus. J Biol Chem 259: 10539–10544

    Google Scholar 

  21. Nakajima H, Sugiura T, Ushimi C (1978) Immunodiffusion test for the diagnosis of equine infectious anemia. In: Bryans JT, Gerber H (eds) Proc 4th Int Conf Equine Infect Dis, Lyon 1976. Vet Pub Inc, Princeton, pp 339–349

    Google Scholar 

  22. Payne S, Montelaro RC, Issel CJ (1984) Genomic alterations associated with persistent infections by equine infectious anemia virus, a retrovirus. J Gen Virol 65: 1395–1399

    Google Scholar 

  23. Scott JV, Stowring L, Hasse AT, Narayan O, Vigne R (1979) Antigenic variation in visna virus. Cell 18: 321–327

    Google Scholar 

  24. Sentsui H, Kono Y (1981) Hemagglutination-inhibition tests with different strains of equine infectious anemia virus. Am J Vet Res 42: 1949–1952

    Google Scholar 

  25. Stephens RM, Casey JW, Rice NR (1986) Equine infectious anemia virusgag andpol genes: relatedness to visna and AIDS virus. Science 231: 589–594

    Google Scholar 

  26. Stowring L, Hasse AT, Charman HP (1979) Serological definition of the lentivirus group of retroviruses. J Virol 29: 523–528

    Google Scholar 

  27. Wong-Staal F, Gallo RC (1985) Human T-lymphotropic retroviruses. Nature 317: 395–403

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. National Institute of Animal Health, Yatabe, Ibaraki, Japan

    Y. Kono

  2. Kyushu Branch Laboratory, National Institute of Animal Health, Chuzan-cho 2702, 891-01, Kagoshima, Japan

    Y. Kono

Authors
  1. Y. Kono
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kono, Y. Antigenic variation of equine infectious anemia virus as detected by virus neutralization. Archives of Virology 98, 91–97 (1988). https://doi.org/10.1007/BF01321009

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01321009

Keywords

Search

Navigation