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Inhibition of rabies virus infection by a soluble membrane fraction from the rat central nervous system

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Summary

This paper describes the inhibitory effect of a normal rat brain solubilized membrane preparation (RBSM-liposomes) on rabies virus infection. Rabies virus was incubated with RBSM-liposomes or their separated components (proteins, phospholipids, gangliosides) before infection of CER or neuroblastoma cells. In addition, both RBSM-liposomes and target cells were treated with enzymes prior to the infection step. All these experimental procedures showed that the active components were mainly lipids.

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Author notes

  1. C. Conti

    Present address: Istituto di Microbiologia, Facoltá di Medicina e Chirurgia, Università “La Sapienza”, Piazzale Aldo Moro 5, I-00185, Roma, Italy

Authors and Affiliations

  1. Institut Pasteur, Paris, France

    C. Conti, B. Hauttecoeur, M. J. Morelec, B. Bizzini & H. Tsiang

  2. Istituto di Microbiologia, Facoltá di Medicina e Chirurgia, Università “La Sapienza”, Piazzale Aldo Moro 5, I-00185, Roma, Italy

    N. Orsi

Authors
  1. C. Conti
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  2. B. Hauttecoeur
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  3. M. J. Morelec
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  4. B. Bizzini
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  5. N. Orsi
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  6. H. Tsiang
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Conti, C., Hauttecoeur, B., Morelec, M.J. et al. Inhibition of rabies virus infection by a soluble membrane fraction from the rat central nervous system. Archives of Virology 98, 73–86 (1988). https://doi.org/10.1007/BF01321007

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  • DOI: https://doi.org/10.1007/BF01321007

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