Summary
Serial serum samples were obtained from 45 pregnant women who had been shown to possess complement fixing (CF) antibodies to cytomegalovirus (CMV) during a previous pregnancy. The serial samples were tested for antibodies against the early antigens (EA) and complement fixing antigens of CMV.
All of the 45 women still possessed CF antibodies at the commencement of their next pregnancy. Six of the 45 women (13 per cent) lacked detectable IFA-EA antibodies whilst 19/45 (42 per cent) women possessed only low titres (≤64) of these antibodies. However, 20/45 (44 per cent) women possessed high titre (≽128) antibodies despite having experienced their primary CMV infection many months previously.
It is concluded that antibodies to the EA of CMV are not as transitory as has been suggested and that their presence, even at high titre, in a serum sample from a pregnant woman cannot be taken as presumptive evidence of recent primary infection with this virus.
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References
Gerna, G., Cereda, P. M., Cattaneo, E., Achilli, G., Revello, M. G.: Immunoglobulin G to virus-specific early antigens in congenital, primary, and reactivated human cytomegalovirus infections. Infect. Immun.22, 833–841 (1978).
Giraldo, G., Beth, E., Hämmerling, U., Tarro, G., Kourilsky, F. M.: Detection of early antigens in nuclei of cells infected with cytomegalovirus or herpes simplex virus type 1 and 2 by anti-complement immunofluorescence, and use of a blocking assay to demonstrate their specificity. Int. J. Cancer19, 107–116 (1977).
Griffiths, P. D., Stagno, S., Reynolds, D. W., Alford, C. A.: A longitudinal study of the serological and virological status of 18 women infected with cytomegalovirus. Arch. Virol.58, 111–118 (1978).
Griffiths, P. D., Buie, K. J., Heath, R. B.: A comparison of complement fixation (CF), indirect immunofluorescence for viral late antigens (IFA-LA) and anti-complement immunofluorescence (ACIF) tests for the detection of cytomegalovirus specific serum antibodies. J. clin. Pathol.31, 827–831 (1978).
Griffiths, P. D., Campbell-Benzie, A., Heath, R. B.: A prospective study of primary cytomegalovirus infection in pregnant women. Brit. J. Obs. Gyn. (in press).
Hanshaw, J. B., Scheiner, A. P., Moxley, A. W., Gaev, L., Abel, V., Scheiner, B.: School failure and deafness after “silent” congenital cytomegalovirus infection. N. Engl. J. Med.295, 468–470 (1976).
Monif, G. R. G., Egan, E. A., Held, B., Eitzman, D. V.: The correlation of maternal cytomegalovirus infection during varying stages in gestation with neonatal involvement. J. Pediatr.80, 17–20 (1972).
Nankervis, G. A., Kumar, M. L., Gold, E.: Primary infection with cytomegalovirus during pregnancy. Ped. Res.8, 427 (1974).
Reynolds, D. W., Stagno, S., Hosty, T. S., Tiller, M., Alford, C. A.: Maternal cytomegalovirus excretion and perinatal infection. N. Engl. J. Med.289, 1–5 (1973).
Reynolds, D. W., Stagno, S., Stubbs, K. G., Dahle, A. J., Livingston, M. M., Saxon, S. S., Alford, C. A.: Inapparent congenital cytomegalovirus infection with elevated cord IgM levels: causal relation with auditory and mental deficiency. N. Engl. J. Med.290, 291–296 (1974).
Reynolds, D. W.: Development of early nuclear antigen in cytomegalovirus infected cells in the presence of RNA and protein synthesis inhibitors. J. gen. Virol.40, 475–480 (1978).
Stagno, S., Reynolds, D. W., Huang, E-S., Thames, S., Smith, R. J., Alford, C. A.: Congenital cytomegalovirus infection: occurrence in an immune population. N. Engl. J. Med.296, 1254–1258 (1977).
Stern, H., Tucker, S. M.: Prospective study of cytomegalovirus infection in pregnancy. Brit. med. J.2, 268–270 (1973).
Stern, H.: Cytomegalovirus vaccine: justification and problems. In:Waterson, A. P. (ed.), Recent Advances in Clinical Virology, 117–134. Edinburgh: Churchill Livingstone 1977
Thé, T. H., Klein, G., Langenhuysen, M. M. A. C.: Antibody reactions to virus-specific early antigens (EA) in patients with cytomegalovirus (CMV) infection. Clin. exp. Immunol.16, 1–12 (1974).
Thé, T. H., Anderson, H. K., Spencer, E. S., Klein, G.: Antibodies against cytomegalovirus-induced early antigens (CMV-EA) in immunosuppressed renal-allograft recipients. Clin. exp. Immunol.28, 502–505 (1977).
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Griffiths, P.D., Buie, K.J. & Heath, R.B. Persistence of high titre antibodies to the early antigens of cytomegalovirus in pregnant women. Archives of Virology 64, 303–309 (1980). https://doi.org/10.1007/BF01320615
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DOI: https://doi.org/10.1007/BF01320615