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Inhibition of foot and mouth disease virus and procapsid synthesis by zinc ions

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Summary

Zinc ions inhibit virus production and viral RNA synthesis in FMDV infected-BHK 21 cells. The degree of inhibition depends upon the zinc concentration and the time of addition of the drug. A differential inhibition on virus and procapsids synthesis was observed.

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References

  1. Baltimore, D.: The replication of picornaviruses: In:Levy, H. B. (ed.), The Biochemistry of Viruses, 101–176. New York: Marcel Dekker 1969.

    Google Scholar 

  2. Black, D. N.: Proteins induced in BHK cells by infection with foot-and-mouth disease virus. J. gen. Virol.26, 109–119 (1975).

    Google Scholar 

  3. Bracha, M., Schlesinger, M. J.: Inhibition of sindbis virus replication by zinc ions. Virology72, 272–277 (1976).

    Google Scholar 

  4. Butterworth, B. E., Korant, B. D.: Characterization of the large picornaviral polypeptides produced in the presence of zinc ion. J. gen. Virol.14, 282–291 (1974).

    Google Scholar 

  5. Fridlender, B., Chejanovsky, N., Becker, Y.: Selected inhibition of herpes simplex virus type 1 DNA polymerase by zinc ions. Virology84, 551–554 (1978).

    Google Scholar 

  6. Korant, B. D., Butterworth, B. E.: Inhibition by zinc of rhinovirus protein cleavage: Interaction of zinc with capsid polypeptides. J. Virol.18, 298–306 (1976).

    Google Scholar 

  7. Nakai, K., Lucas-Lenard, J.: Processing of mengovirus precursor polypeptides in the presence of zinc ions and sulphydril compounds. J. Virol.18, 918–925 (1976).

    Google Scholar 

  8. Polatnick, J., Bachrach, H. L.: Effect of zinc and other chemical agents on foot-and-mouth disease virus replication. Antimicrob. Ag. Chemother.13, 731–734 (1978).

    Google Scholar 

  9. Rowlands, D. J., Sangar, D. V., Brown, F.: A comparative chemical and serological study of the full and empty particles of foot-and-mouth disease virus. J. gen. Virol.26, 227–238 (1975).

    Google Scholar 

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Firpo, E.J., Palma, E.L. Inhibition of foot and mouth disease virus and procapsid synthesis by zinc ions. Archives of Virology 61, 175–181 (1979). https://doi.org/10.1007/BF01320603

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  • DOI: https://doi.org/10.1007/BF01320603

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