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Digestive Diseases and Sciences

, Volume 29, Issue 9, pp 872–874 | Cite as

Acute necrosis of the intestinal mucosa with high serum levels of diamine oxidase

  • Gustavo Bounous
  • Vincent Echavé
  • Suzanne J. Vobecky
  • Henri Navert
  • Armin Wollin
Case Report

Summary

A patient with acute necrosis of the intestinal mucosa and high serum diamine oxidase activity is described. The 71-year-old woman, with a history of hypertension and cardiovascular and peripheral arteriosclerotic disease, presented with acute epigastric pain, vomiting, and a deteriorating hemodynamic condition. Serum level of the intestinal enzyme diamine oxidase (DAO) obtained on admission, approximately 24 hr after the onset of symptoms, was 7.4 times above the normal value. An exploratory laparotomy performed 6 hr later revealed cyanosis and areas of transmural necrosis involving the entire small bowel. The bowel was not resected because of the extent of lesion. Thirty hours after the first sample was taken and 2 hr before death, the serum DAO level was only slightly above normal. It is suggested that this biochemical marker could provide a valuable tool for the early diagnosis of intestinal ischemia.

Keywords

Small Bowel High Serum Oxidase Activity Biochemical Marker Intestinal Mucosa 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Gustavo Bounous
    • 1
  • Vincent Echavé
    • 1
  • Suzanne J. Vobecky
    • 1
  • Henri Navert
    • 1
  • Armin Wollin
    • 1
  1. 1.Centre de recherches en physiopathologie digestive, Faculty of medicineUniversity of SherbrookeSherbrookeCanada

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