Digestive Diseases and Sciences

, Volume 29, Issue 9, pp 872–874 | Cite as

Acute necrosis of the intestinal mucosa with high serum levels of diamine oxidase

  • Gustavo Bounous
  • Vincent Echavé
  • Suzanne J. Vobecky
  • Henri Navert
  • Armin Wollin
Case Report


A patient with acute necrosis of the intestinal mucosa and high serum diamine oxidase activity is described. The 71-year-old woman, with a history of hypertension and cardiovascular and peripheral arteriosclerotic disease, presented with acute epigastric pain, vomiting, and a deteriorating hemodynamic condition. Serum level of the intestinal enzyme diamine oxidase (DAO) obtained on admission, approximately 24 hr after the onset of symptoms, was 7.4 times above the normal value. An exploratory laparotomy performed 6 hr later revealed cyanosis and areas of transmural necrosis involving the entire small bowel. The bowel was not resected because of the extent of lesion. Thirty hours after the first sample was taken and 2 hr before death, the serum DAO level was only slightly above normal. It is suggested that this biochemical marker could provide a valuable tool for the early diagnosis of intestinal ischemia.


Small Bowel High Serum Oxidase Activity Biochemical Marker Intestinal Mucosa 
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  1. 1.
    Bounous G: Acute necrosis of the intestinal mucosa. Gastroenterology 82:1457–1467, 1982Google Scholar
  2. 2.
    Wollin A, Navert H, Bounous G: Effect of intestinal ischemia on diamine oxidase activity in rat intestinal tissue and blood. Gastroenterology 80:349–355, 1981Google Scholar
  3. 3.
    Okuyama T, Kobayashi Y: Determination of diamine oxidase activity by liquid scintillation counting. Arch Biochem Biophys 95:242–250, 1961Google Scholar
  4. 4.
    Muggia FM: Hemorrhagic necrosis of the intestine: Its occurrence with digitals intoxication. Am J Med Sci 253:263–271, 1967Google Scholar
  5. 5.
    Baylin SB, Beaven MA, Buja LM, Keiser HR: Histaminase activity: A biochemical marker for medullary carcinoma of the thyroid. Am J Med 53:723–733, 1972Google Scholar
  6. 6.
    Shaff RE, Beaven MA: Turnover and synthesis of diamine oxidase (DAO) in rat tissue. Studies with heparin and cycloheximide. Biochem Pharmacol 25:1057–1062, 1976Google Scholar
  7. 7.
    Shakir KMM, Margolis S, Baylin SB: Localization of histaminase (diamine oxidase) in rat small intestinal mucosa: Site of release by heparin. Biochem Pharmacol 26:2343–2347, 1977Google Scholar
  8. 8.
    Bieganski T, Kusche J, Lorenz W, Hesterberg R, Stahlknecht C, Feussner K: Distribution and properties of human intestinal diamine oxidase and its relevance for the histamine catabolism. Biochim Biophys Acta 756:196–203, 1983Google Scholar
  9. 9.
    Southern AL, Kobayashi Y, Sherman DH, Levine L, Gordon G, Weingold AB: Diamine oxidase in human pregnancy. Am J Obstet Gynecol 89:199–203, 1964Google Scholar
  10. 10.
    Baylin SB, Beaven MA, Krause RM, Keiser HR: Response of plasma histaminase activity to small doses of heparin in normal subjects and patients with hyperlipoproteinemia. J Clin Invest 52:1985–1993, 1973Google Scholar
  11. 11.
    Ettinger DS, Baylin SB, Minaberry D, Abeloff MD, Mellits ED: Response of plasma histaminase activity to heparin in normal subjects and in patients with small cell carcinoma of the lung. J Natl Cancer Inst 60:1239–1242, 1978Google Scholar
  12. 12.
    Bayless TM, Luk GD, Baylin SB, Thomas ME: Decreased plasma diamine oxidase levels with Crohn's disease and celiac disease. Gastroenterology 80:1106A, 1981Google Scholar
  13. 13.
    Wollin A, Navert H, Bounous G: Intestinal ischemia and diamine oxidase activity. Reply. Gastroenterology 81:198–199, 1981Google Scholar
  14. 14.
    Wollin A, Navert H, Bounous G: Release of diamine oxidase during intestinal ischemia in the rat. Clin Res 27:623A, 1979Google Scholar

Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Gustavo Bounous
    • 1
  • Vincent Echavé
    • 1
  • Suzanne J. Vobecky
    • 1
  • Henri Navert
    • 1
  • Armin Wollin
    • 1
  1. 1.Centre de recherches en physiopathologie digestive, Faculty of medicineUniversity of SherbrookeSherbrookeCanada

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