Summary
Ultraviolet irradiation of cells after stimulation with polyinosinate-polycytidilate markedly enhanced and prolonged the production of interferon in human diploid fibroblasts. It further boosted the interferon production, when applied to cells primed with interferon.
This is a preview of subscription content, log in via an institution to check access.
References
Armstrong, J. A.: Semi-micro, dye-binding method for rabbit interferon. Appl. Microbiol.21, 723–725 (1971).
Billiau, A., Joniau, M., DeSomer, P.: Mass production of human interferon in diploid cells stimulated by poly IC. J. gen. Virol.19, 1–8 (1973).
Cavalieri, R. L., Havell, E. A., Vilček, J., Pestka, S.: Induction and decay of human fibroblast interferon m-RNA. Proc. Nat. Acad. Sci. U.S.A.74, 4415–4419 (1977).
Havell, E. A., Vilček, J.: Production of high-titered interferon in cultures of human diploid cells. Antimicrob. Agents Chemother.2, 476–484 (1972).
Ho, M., Tan, Y. H., Armstrong, J. A.: Accentuation of production of human interferon by metabolic inhibitors. Proc. Soc. exp. Biol. Med.139, 259–262 (1972).
Kohase, M., Vilček, J.: Studies on the enhancement of interferon production in human diploid (FS-4) cells by ultraviolet. Japan. J. med. Sci. Biol.31, 17–26 (1978).
Komatsu, H., Maehara, N., Shimoda, K., Mori, T., Lee, T., Makino, S., Matumoto, M.: Production of interferon in human diploid cells at different population doubling levels. Arch. Virol.70, 367–371 (1981).
Linder-Frimmel, S. J.: Enhanced production of human interferon by UV irradiated cells. J. gen. Virol.25, 147–150 (1974).
Maehara, N., Komatsu, H., Shimoda, K., Makino, S., Nagano, Y., Matumoto, M.: Enhanced production of virus-inhibiting factor (interferon) in human diploid cells by ultraviolet irradiation and temperature shift-down after stimulation with Newcastle disease virus. Microbiol. Immunol.24, 907–914 (1980).
Meager, A., Graues, H. E., Shuttlew, J., Zucker, N.: Interferon production: variation in yields from human cell lines. Infect. Immun.25, 658–663 (1979).
Mozes, L. W., Vilček, J.: Distinguishing characteristics of interferon induction with poly(I) · poly(C) and Newcastle disease virus in human cells. Virology65, 100–111 (1975).
Sehgal, P. B., Dobberstein, B., Tamm, I.: Interferon messenger RNA content of human fibroblasts during induction, shutoff and superinduction of interferon production. Proc. Nat. Acad. Sci. U.S.A.74, 3409–3413 (1977).
Author information
Authors and Affiliations
Additional information
With 2 Figures
Rights and permissions
About this article
Cite this article
Komatsu, H., Maehara, N., Shimoda, K. et al. Enhanced production of interferon by ultraviolet irradiation and pretreatment with interferon in human diploid cells stimulated with polyinosinate-polycytidilate. Archives of Virology 73, 337–341 (1982). https://doi.org/10.1007/BF01318087
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01318087