Summary
Analogues of pyrophosphate have been tested as inhibitors of influenza virus RNA polymerase activity in cell-free assays. The most active compound, phosphonoformic acid (PFA), reduced the polymerase activity to 50 per cent at a concentration of 20 µm. The inhibition was dependent on the type of divalent cation present in the assay. PFA at a concentration of 400 µm also inhibited the influenza virus plaque formation by 90 per cent.
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Stridh, S., Helgstrand, E., Lannerö, B. et al. The effect of pyrophosphate analogues on influenza virus RNA polymerase and influenza virus multiplication. Archives of Virology 61, 245–250 (1979). https://doi.org/10.1007/BF01318059
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DOI: https://doi.org/10.1007/BF01318059