Summary
The genotypic composition of several H3N2 vaccinal strains made from PR/8/34 and different wild isolates has been determined. The results suggested that specific gene constellations at the level of the 3 largest RNA fragments, coding the 3 “polymerase proteins” are responsible for their consistent attenuation.
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Part of this study was supported by a grant from the Institut pour l'Encouragement de la Recherche Scientifique dans l'Industrie et l'Agriculture (I.R.S.I.A.).
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Florent, G. Gene constellation of live influenza A vaccines. Archives of Virology 64, 171–173 (1980). https://doi.org/10.1007/BF01318021
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DOI: https://doi.org/10.1007/BF01318021