Summary
Difference in antibody responses between varicella and herpes zoster was reconfirmed by complement fixation (CF) test and by platelet aggregation (PA) test. Rise in PA antibody level was observed only in patients with herpes zoster, but not in patients with varicella, while the increase in CF antibody was demonstrated in both types of the diseases. Among 235 healthy children, CF antibody was detected in 42 children and out of these 25 also had PA antibody. Sera of 116 individuals who were vaccinated with a live vaccine comprised of varicellaherpes zoster virus (VZV) were tested for CF and PA antibodies. Within six months after vaccination, 81.3 per cent of the vaccinees demonstrated the rise in CF antibody alone, and only one vaccinee possessed low level of PA antibody. Six months to 1 year after vaccination, CF antibody in 12 out of 13 vaccinees fell to undetectable level. Later than 1 year after vaccination, 9 out of 28 vaccinees possessed CF antibody. Two out of these 9 vaccinees also had PA antibody.
The PA antigens prepared from viruses isolated either from a varicella patient or a herpes zoster patient responded similarly to the sera of herpes zoster patients, but no response was detected with sera of varicella patients. PA and CF antibody titers of herpes zoster patients showed a high degree of correlation.
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Aster, R. H., Jandl, J. H.: Platelet sequestration in man. I. Methods. J. clin. Invest.43, 843–855 (1964)
Boucherat, R. J. M.: Herpes zoster ophthalmicus with trochlear nerve involvement after alcohol injection into the Gasserian ganglion. Ophthalmol.55, 761–765 (1971).
Duncan, C.: Reactivation of varicella virus in trigeminal ganglion. Lancetii, 1203 (1976).
Hope-Simpson, R. E.: The nature of herpes zoster. A long-term study and a new hypothesis. Proc. Roy. Soc. Med.58, 9–20 (1965).
Kunita, N., Kitawaki, T., Funahashi, S., Toyashima, K.: Comparison of the hemagglutination-inhibition test for measles with serological tests and its application to a field trial. Biken J.6, 45–56 (1963).
Miller, L. H., Brunell, P. A.: Zoster, reinfection or activation of latent virus? Observations on the antibody response. Amer. J. Med.49, 480–483 (1970).
Myllylä, G., Vaheri, A., Vesikari, T., Penttinen, K.: Interaction between human blood platelets, viruses and antibodies. VI. Post-rubella thrombocytopenic purpura and platelet aggregation by rubella antigen-antibody intraction. Clin. exp. Immunol.4, 323–332 (1969).
Nii, S., Maeda, Y.: Studies of herpes zoster virusin vitro. I. Isolation of two variants. Biken J.12, 219–230 (1969).
Palosuo, T., Penttinen, K., Myllylä, G.: Platelet aggregation by herpes simplex antigen-antibody complexes. Arch. ges. Virusforsch.31, 11–17 (1970).
Palosuo, T., Salmi, A., Pettay, O.: Measles antibody detected by platelet aggregation and gel precipitation in patient with subacute sclerosing panencephalitis. Arch. ges. Virusforsch.35, 45–53 (1971).
Palosuo, T.: Varicella and herpes zoster: Differences in antibody response revealed by the platelet aggregation technique. Scand. J. infect. Dis.4, 83–89 (1972).
Panelius, M., Myllylä, G., Penttinen, K., Halonen, P., Rinne, U. K.: Platelet aggregation test with measles antigen in multiple sclerosis. Brit. med. J.2, 461–462 (1970).
Penttinen, K., Myllylä, G.: Interaction between blood platelets, viruses and antibodies. I. Platelet aggregation test with microequipment. Ann. med. exp. Fenn.46, 188–192 (1968).
Penttinen, K., Myllylä, G., Mäkelä, O., Vaheri, A.: Soluble antigen-antibody complexes and platelet aggregation. Act. Pathol. Microbiol. Scand.77, 309–317 (1969).
Pettay, O., Donner, M., Halonen, H., Palosuo, T., Salmi, A.: Subacute sclerosing panencephalitis: Preceding intellectual deterioration and derivant measles serology. J. inf. Dis.124, 439–444 (1971).
Takahashi, M., Otsuka, T., Okuno, Y., Asano, Y., Yazaki, T., Isomura, S.: Live vaccine used to prevent the spread of varicella in children in hospital. Lancetii, 1288–1290 (1974).
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Kimoto, T., Kurimura, T. Differences in antibody responses in varicella, herpes zoster and after vaccination. Archives of Virology 59, 59–67 (1979). https://doi.org/10.1007/BF01317895
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DOI: https://doi.org/10.1007/BF01317895